当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Can the aggregation be a new approach for understanding the mechanism of Traditional Chinese Medicine?

Can the aggregation be a new approach for understanding the mechanism of Traditional Chinese Medicine?

Abstract：

:"Frequent hitter" phenomenon emerged in the high-throughput screening; one of the most common mechanisms behind artifactual inhibition is that some organic molecules formed large colloid-like aggregates which are able to sequester and thereby inhibit enzymes. To investigate the situation in Traditional Chinese Medicine (TCM), 60 medicinal herbs and 24 Chinese herbal formulae were detected by dynamic light scattering (DLS), and aggregates were observed in all the 84 solution mixtures. The aggregates of two Chinese herbal formulae, 'Xue-Fu-Zhu-Yu Tang' (XF) and 'Jing-Guan Tang' (JG), were not only able to survive in the gastro-intestinal environment, but also had the ability to pass through the monolayer of the Caco-2 cell. The activities of XF and JG against three cardiovascular targets were also aggregates-related. Based on these findings, a new possible mechanism of the action of Chinese medicine was proposed.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Zhuang Y,Yan J,Zhu W,Chen L,Liang D,Xu X

doi

10.1016/j.jep.2008.02.017

subject

Has Abstract

pub_date

2008-05-08 00:00:00

pages

378-84

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(08)00077-9

journal_volume

117

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • In vitro anti-proliferative and antioxidant studies on Devil's Club Oplopanax horridus.

    abstract：:Devil's Club, Oplopanax horridus (OH), is a widely used folk medicine in Alaska and British Columbia for treating a variety of ailments including arthritis, fever and diabetes. HPLC profiling shows that numerous compounds are present in the 70% ethanolic extract of OH dry root bark powder. OH extract inhibited K562, H...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.05.018

    authors： Tai J,Cheung S,Cheah S,Chan E,Hasman D

    更新日期：2006-11-24 00:00:00

  • Pallidifloside D, a saponin glycoside constituent from Smilax riparia, resist to hyperuricemia based on URAT1 and GLUT9 in hyperuricemic mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The roots and rhizomes of Smilax riparia (SR), called "Niu-Wei-Cai" in traditional Chinese medicine (TCM), are believed to be effective in treating hyperuricemia and gout symptoms. This study was designed to isolate a saponin glycoside named pallidifloside D from the total saponins of Smi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.09.034

    authors： Wu XH,Ruan JL,Zhang J,Wang SQ,Zhang YW

    更新日期：2014-11-18 00:00:00

  • Toxicity studies of medicinal plants used in sub-Saharan Africa.

    abstract：:In sub-Saharan Africa, traditional medicine is widely used in rural and urban areas also. This is essentially due to the prohibitive cost of pharmaceutical-based medicine and the low incomes of a major part of the population. In addition, the efficacies of many of these traditional and plant-based medicines are proven...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2015.06.005

    authors： Boukandou Mounanga M,Mewono L,Aboughe Angone S

    更新日期：2015-11-04 00:00:00

  • UHPLC/Q-TOFMS-based metabolomics for the characterization of cold and hot properties of Chinese materia medica.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The cold/hot property of Chinese materia medica (CMM) and the application of its corresponding knowledge in the diagnosis, differentiation and treatment of diseases have been considered to be the extremely important part of traditional Chinese medicine (TCM). As highly abstracted TCM theo...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.12.061

    authors： Wang Y,Zhou S,Wang M,Liu S,Hu Y,He C,Li P,Wan JB

    更新日期：2016-02-17 00:00:00

  • Plants used for stress-related ailments in traditional Zulu, Xhosa and Sotho medicine. Part 1: Plants used for headaches.

    abstract：:The usage and indications of possible therapeutic and harmful effects of 96 plants reported to be used for headaches in traditional Zulu, Xhosa and Sotho medicine are reviewed. Although few pharmacological studies have been undertaken on the plants used, related usage by other ethnic groups and known properties in rel...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0378-8741(94)90008-6

    authors： Hutchings A,van Staden J

    更新日期：1994-07-08 00:00:00

  • Prescription patterns of Chinese herbal products for menopausal syndrome: analysis of a nationwide prescription database.

    abstract：UNLABELLED:ETHNO-PHARMACOLOGICAL RELEVANCE: Chinese herbal products (CHP) are commonly used for menopausal syndrome in traditional Chinese medicine (TCM). AIM OF THE STUDY:Because menopausal syndrome is a common issue among women worldwide, this study analyzed the prescription patterns and frequencies of CHP in reliev...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.07.053

    authors： Chen HY,Lin YH,Wu JC,Chen YC,Yang SH,Chen JL,Chen TJ

    更新日期：2011-10-11 00:00:00

  • Antinociceptive and anti-inflammatory effects of compounds isolated from Scaphyglottis livida and Maxillaria densa.

    abstract：:Oral administration of a CH(2)Cl(2)-MeOH (1:1) extract of Scaphyglottis livida produced dose-dependent antinociceptive and anti-inflammatory effects when tested in mice and rats using the hot-plate (150-600 mg/kg) and carrageenan-induced inflammation (150-600 mg/kg) models, respectively. Morphine (1.5-6 mg/kg, p.o.) a...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.07.021

    authors： Déciga-Campos M,Palacios-Espinosa JF,Reyes-Ramírez A,Mata R

    更新日期：2007-11-01 00:00:00

  • Protective effects of organic acid component from Taraxacum mongolicum Hand.-Mazz. against LPS-induced inflammation: Regulating the TLR4/IKK/NF-κB signal pathway.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:TMHM is a type of Chinese medicine commonly used in medical practice and has multiple functions, including clearing heat, detoxification, reducing swelling, and tumor therapy. Previous research has demonstrated that the OAC of TMHM (TMHM-OAC) displays advantageous therapeutic action again...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.08.044

    authors： Yang N,Dong Z,Tian G,Zhu M,Li C,Bu W,Chen J,Hou X,Liu Y,Wang G,Jia X,Di L,Feng L

    更新日期：2016-12-24 00:00:00

  • Bioactive Lignans from Zanthoxylum alatum Roxb. stem bark with cytotoxic potential.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Zanthoxylum alatum is used in traditional medicinal systems for number of disorders like cholera, diabetes, cough, diarrhea, fever, headache, microbial infections, toothache, inflammation and cancer. The aim of the present study was to evaluate Zanthoxylum alatum stem bark for its cytotox...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.12.039

    authors： Mukhija M,Lal Dhar K,Nath Kalia A

    更新日期：2014-02-27 00:00:00

  • Bakera, a herbal steam bath for postnatal care in Minahasa (Indonesia): documentation of the plants used and assessment of the method.

    abstract：:Bakera, a steam bath prepared with various plants, is a traditional method used in Minahasa (North Sulawesi, Indonesia) for recuperation after childbirth. Semi-structured interviews were conducted with 14 midwives and 166 mothers in different villages of Minahasa, in order to document the preparation and plants used f...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.01.016

    authors： Zumsteg IS,Weckerle CS

    更新日期：2007-05-22 00:00:00

  • Polygonum multiflorum Thunb suppress bile acid synthesis by activating Fxr-Fgf15 signaling in the intestine.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Polygonum multiflorum Thunb (Heshouwu, HSW) is commonly used in clinical medicine, while the hepatotoxicities of HSW are reported increasingly in recent years. Currently, researchers have demonstrated an essential role of Bile Acids (BAs) in liver diseases. The occurrence of hepatotoxicit...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.12.007

    authors： Wei J,Chen J,Fu L,Han L,Gao X,Sarhene M,Hu L,Zhang Y,Fan G

    更新日期：2019-05-10 00:00:00

  • The water expelling effect evaluation of 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol and ingenol on H22 mouse hepatoma ascites model and their content differences analysis in Euphorbia kansui before and after stir-fried with vinegar by UPLC.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Malignant ascites (MA) effusion is mainly caused by hepatocellular, ovarian, and breast cancer etc. It has been reported that Euphorbia kansui (EK), the root of Euphorbia kansui S.L.Liou ex S.B.Ho, possessing a therapeutic effect on MA. However, the clinical applications of EK are serious...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113507

    authors： Zhang Q,Ju YH,Zhang Y,Wang K,Zhang M,Chen PD,Yao WF,Tang YP,Wu JH,Zhang L

    更新日期：2021-03-01 00:00:00

  • Hypoglycemic effect of the water extract of Smallantus sonchifolius (yacon) leaves in normal and diabetic rats.

    abstract：:The hypoglycemic effect of the water extract of the leaves of Smallantus sonchifolius (yacon) was examined in normal, transiently hyperglycemic and streptozotocin (STZ)-induced diabetic rats. Ten-percent yacon decoction produced a significant decrease in plasma glucose levels in normal rats when administered by intrap...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00351-2

    authors： Aybar MJ,Sánchez Riera AN,Grau A,Sánchez SS

    更新日期：2001-02-01 00:00:00

  • Puerarin attenuates glutamate-induced neurofilament axonal transport impairment.

    abstract：AIM OF THE STUDY:Puerarin (Pur) is a primary component of the most functional extracts of Pueraria lobata used in traditional Chinese medicine for centuries. Since it has been postulated that Pur protects the brain against glutamate (Glu) neurotoxicity, we investigated the effects of Pur on Glu-induced axonal transport...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.08.005

    authors： Zhou J,Wang H,Xiong Y,Li Z,Feng Y,Chen J

    更新日期：2010-10-28 00:00:00

  • Antibacterial activity and in vitro anti-tumor activity of the extract of the larvae of the housefly (Musca domestica).

    abstract：:One of the significant characteristics of traditional Chinese medicine is the use of insects, other terrestrial arthropods and their products as drugs. In the present work, the extract of housefly (Musca domestica) larvae was studied by an agar well diffusion assay and minimum bactericidal concentration (MBC) determin...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.11.015

    authors： Hou L,Shi Y,Zhai P,Le G

    更新日期：2007-05-04 00:00:00

  • A pharmacological study of Cecropia obtusifolia Bertol aqueous extract.

    abstract：:Cecropia obtusifolia (Cecropiaceae) is a species from tropical America and its leaves are used in traditional medicine for the treatment of diabetes and as an anti-inflammatory agent. In the present study, the analgesic, anti-inflammatory and central nervous system depressant effects of the aqueous extract from the le...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00253-7

    authors： Pérez-Guerrero C,Herrera MD,Ortiz R,Alvarez de Sotomayor M,Fernández MA

    更新日期：2001-08-01 00:00:00

  • Toxicological studies of the aqueous extract from Achyrocline satureioides (Lam.) DC (Marcela).

    abstract：:Achyrocline satureioides (Lam.) DC (Marcela) is known to possess a broad spectrum of pharmacological, medicinal and therapeutic properties. Previous studies have demonstrated various protective abilities of the marcela extracts against various pathological conditions. However, no extensive safety studies have been con...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.08.013

    authors： Rivera F,Gervaz E,Sere C,Dajas F

    更新日期：2004-12-01 00:00:00

  • Prevention of hepatic injury by a traditional Chinese formulation, BJ-JN, in mice treated with Bacille-Calmette-Guérin and lipopolysaccharide.

    abstract：:The hepatoprotective effects of BJ-JN (a traditional Chinese formulation) were evaluated in Bacille-Calmette-Guérin and lipopolysaccharide (BCG/LPS)-induced immunological liver injury (ILI) in mice. BJ-JN (0.75, 1.5, 3 g/kg) was administered via gavage daily for 10 days. Liver index (liver weight/body weight), serum l...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.04.006

    authors： Zou Y,Yang Y,Li J,Li W,Wu Q

    更新日期：2006-10-11 00:00:00

  • Antidiarrhoeal and intestinal modulatory activities of Wei-Chang-An-Wan extract.

    abstract：AIM OF THE STUDY:Wei-Chang-An-Wan (WCAW), a traditional pharmaceutical preparation, has been used for treating various gastrointestinal (GI) diseases for several decades, but it is still poorly understood how it works on those disorders. This study was to investigate the effects of WCAW extract on GI tract. MATERIALS ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.07.027

    authors： Hu J,Gao WY,Ling NS,Liu CX

    更新日期：2009-09-25 00:00:00

  • Double-blind randomized placebo-controlled trial on efficacy and safety of Lactuca sativa L. seeds on pregnancy-related insomnia.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:There is limited evidence about the role of herbal and traditional medicine in pregnancy-related insomnia. Extant documents on traditional Persian medicine refer to many plants which could induce sleep and which were used by pregnant women. In Iran, local herbal shops continue to provide ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jep.2018.08.001

    authors： Pour ZS,Hosseinkhani A,Asadi N,Shahraki HR,Vafaei H,Kasraeian M,Bazrafshan K,Faraji A

    更新日期：2018-12-05 00:00:00

  • Antihypertensive effect of Phragmanthera incana (Schum) Balle on NG-nitro-L-Arginine methyl ester (L-NAME) induced hypertensive rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Phragmanthera incana (Schum) Balle is a member of the African mistletoes that has been reported to be used in ethnomedicine for the treatment of hypertension. AIM:The aim of this study was to investigate the antihypertensive effect of Phragmanthera incana leaf ethanol extract (PILEE) in ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112888

    authors： Adedapo ADA,Ajayi AM,Ekwunife NL,Falayi OO,Oyagbemi A,Omobowale TO,Adedapo AA

    更新日期：2020-07-15 00:00:00

  • Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss.

    abstract：:Galangin is one of the active antimicrobial principles of propolis or 'bee glue' and Helichrysum aureonitens, a perennial herb used by South African indigenes to treat infection. The effect of this compound and antibacterial agents with known mechanisms of action upon the cytoplasmic membrane integrity of Staphylococc...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.04.014

    authors： Cushnie TP,Lamb AJ

    更新日期：2005-10-03 00:00:00

  • Abortifacient potential of methanolic extract of Anthocephalus cadamba stem bark in mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants possessing abortifacient activity have been used traditionally for a long time in folk medicine. Anthocephalus cadamba, is one such herb that has been known to possess abortifacient potential in ethnobotanical literature, but has not been validated scientifically. MATERI...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.07.031

    authors： Shaikh MV,Kala M,Ravat N,Nivsarkar M

    更新日期：2015-09-15 00:00:00

  • A review on the elemental contents of Pakistani medicinal plants: Implications for folk medicines.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Substantially, plants produce chemicals such as primary and secondary metabolites, which have significant applications in modern therapy. Indigenous people mostly rely on traditional medicines derived from medicinal plants. These plants have the capacity to absorb a variety of toxic eleme...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2016.05.011

    authors： Aziz MA,Adnan M,Begum S,Azizullah A,Nazir R,Iram S

    更新日期：2016-07-21 00:00:00

  • Anti-stress effects of ginseng total saponins on hindlimb-unloaded rats assessed by a metabolomics study.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ginseng, the roots and rhizomes of Panax ginseng C.A. Mey. (Araliaceae), is used as a tonic herb for thousands of years in Asian countries. Saponins are recognized as its major active ingredients and reportedly can ease disorders caused by various adverse stimuli. Nevertheless, it is uncl...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.04.028

    authors： Feng L,Liu XM,Cao FR,Wang LS,Chen YX,Pan RL,Liao YH,Wang Q,Chang Q

    更新日期：2016-07-21 00:00:00

  • Maimendong and Qianjinweijing Tang (Jin formula) suppresses lung cancer by regulation of miR-149-3p.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Maimendong and Qianjinweijing Tang (Jin formula), a classic Chinese formula, can enhance therapeutic efficacy and reduce adverse effects in patients with lung cancer. AIM OF THE STUDY:To evaluate the anti-lung cancer effect of Jin formula in vivo and in vitro, and to explore the role of ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112836

    authors： Jiang Z,Ma Y,Tian T,Sun Y,Chen H,Lu Y,Wu Y,Jiang H,Li W,Li L,Zhou H,Wu M

    更新日期：2020-08-10 00:00:00

  • Hypoglycaemic effect of spergularia purpurea in normal and streptozotocin-induced diabetic rats.

    abstract：:Single and repeated oral administration of the water extracts of Spergularia purpurea (SP) at a dose of 10 mg/kg were tested on hypoglycaemic activity in normal and streptozotocin-induced diabetic rats. In normal rats, the water extract of SP decreased significantly the plasma glucose levels 4 h after single oral admi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(99)00199-3

    authors： Jouad H,Eddouks M,Lacaille-Dubois MA,Lyoussi B

    更新日期：2000-07-01 00:00:00

  • Traditional herbal drugs of southern Uganda, I.

    abstract：:One-hundred four plant species used medicinally by herbalists from three southern Ugandan tribes were collected and identified. The collection includes a large portion of the materia medica of the Abayanda of the southwest region, as well as species used by herbalists of the Baganda and Bakiga Tribes. Literature searc...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00180-x

    authors： Hamill FA,Apio S,Mubiru NK,Mosango M,Bukenya-Ziraba R,Maganyi OW,Soejarto DD

    更新日期：2000-06-01 00:00:00

  • The genus Pterocaulon (Asteraceae) - A review on traditional medicinal uses, chemical constituents and biological properties.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Species of the genus Pterocaulon (Asteraceae) are used in different parts of the world for treating skin and liver diseases, as well as disorders of the respiratory system, among others. AIM OF THE STUDY:This review aims to discuss the present state of the art concerning the ethnobotanic...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2018.06.012

    authors： Medeiros-Neves B,Teixeira HF,von Poser GL

    更新日期：2018-10-05 00:00:00

  • Vasorelaxant action of an ethylacetate fraction of Euphorbia humifusa involves NO-cGMP pathway and potassium channels.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Euphorbia humifusa Willd. (EH) is an important traditional Chinese medicine that has commonly been used for treating bacillary dysentery and enteritis in many Asian countries for thousands of years. EH has a wide variety of pharmacological actions such as antioxidant, hypotensive, and hyp...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.05.025

    authors： Wang TT,Zhou GH,Kho JH,Sun YY,Wen JF,Kang DG,Lee HS,Cho KW,Jin SN

    更新日期：2013-07-09 00:00:00