Propolis: lymphocyte proliferation and IFN-gamma production.

Abstract:

:We evaluated propolis influence on polyclonal activation of lymphocytes by concanavalin A (Con A). The in vitro experiments showed that propolis decreases splenocyte proliferation both in the absence or presence of Con A. The suppression in mitogen-induced splenocyte proliferation also occurred when mice were treated intraperitoneally with propolis for 3 days. An increased of IFN-gamma production in the culture supernatants of the same cells was observed. A dual action of propolis on lymphocyte activation was proposed: it decreases splenocyte proliferation in the presence or absence of Con A and stimulates IFN-gamma production by spleen cells. These results are important to understand the immunomodulatory action of propolis on the host's specific and non-specific immunity.

journal_name

J Ethnopharmacol

authors

Sá-Nunes A,Faccioli LH,Sforcin JM

doi

10.1016/s0378-8741(03)00121-1

keywords:

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

93-7

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378874103001211

journal_volume

87

pub_type

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