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Immunostimulant effects of Capparis zeylanica Linn. leaves.

Abstract：

:The present study was undertaken to explore the immunomodulatory activity of ethanolic and water extracts of Capparis zeylanica Linn. (family: Capparidaceae) leaves on neutrophil adhesion test, humoral response to sheep red blood cells, delayed-type hypersensitivity, phagocytic activity and cyclophosphamide-induced myelosuppression. Pre-treatment of water extract (300 mg/kg, oral) of Capparis zeylanica evoked a significant increase in neutrophil adhesion to nylon fibres. The augmentation of humoral immune response to sheep red blood cells by ethanolic and water extracts (150-300 mg/kg) is evidenced by increase in antibody titres in mice. A dose-related increase in both primary and secondary antibody titre was observed. Oral administration of ethanolic and water extracts of Capparis zeylanica leaves, at doses of 150 and 300 mg/kg in mice, dose dependently potentiated the delayed-type hypersensitivity reaction induced by sheep red blood cells. Immunomodulatory activity was also assessed by serological and haematological tests. Capparis zeylanica extracts prevented myelosuppression in mice treated with cyclophosphamide drug. The study comprised the acute toxicity and preliminary phytochemical screening of the ethanol and water extracts.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Ghule BV,Murugananthan G,Nakhat PD,Yeole PG

doi

10.1016/j.jep.2006.03.041

subject

Has Abstract

pub_date

2006-11-24 00:00:00

pages

311-5

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(06)00233-9

journal_volume

108

pub_type

杂志文章

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