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Evaluation of the toxicity of Solanum lycocarpum in the reproductive system of male mice and rats.

Abstract：

:Powdered Solanum lycocarpum fruit is commonly used to treat diabetes, but apparently no studies have been conducted to evaluate potential adverse side effects. In the present paper the toxic effect of S. lycocarpum was evaluated in adult male Wistar rats and Swiss mice. The administration of an aqueous extract prepared using a powder obtained from the S. lycocarpum fruit at two different dose levels (60 mg/15 ml and 120 mg/15 ml distilled water for rats and 30 mg/15 ml and 60 mg/15 ml distilled water for mice, twice daily for 5 days in each case) did not produce body weight variations in either species although a significant weight change was observed in some organs. Significant weight loss was observed only in the ventral prostate of mice receiving the high dose treatment. These results suggest a toxic effect of S. lycocarpum on the male reproductive system of the Swiss mouse, with possible antiandrogenic activity, but there was no apparent antifertility activity in rats at the doses given.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

de Cássia da SeSá R,Vireque AA,Reis JE,Guerra MO

doi

10.1016/s0378-8741(00)00250-6

keywords:

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

283-7

issue

1-2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(00)00250-6

journal_volume

73

pub_type

杂志文章

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