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Effects of alkaloids of Himatanthus lancifolius (Muell. Arg.) Woodson, Apocynaceae, on smooth muscle responsiveness.

Abstract：

:Himatanthus lancifolius, popularly known as "agoniada" in Brazil, is largely used in folk medicine against asthma, dysmenorrhea and as an emenagogue and abortive. This study reveals the effects of an alkaloid rich fraction (AlkF) obtained from the bark of Himatanthus lancifolius in vascular and non-vascular smooth muscle responsiveness. Incubation of AlkF (3-30 microg/ml) during 15 min generates a concentration-related and fully reversible reduction in maximal contractile responses evoked by acetylcholine and phenylephrine in rat jejune and aorta preparations, respectively. Exposition of endothelium-denuded pre-contracted rat aorta rings to AlkF results in a complete relaxation, with EC(50) of 22.2 (16.2-28.2 microg/ml). AlkF is also able to induce a concentration-related rightward shift of cumulative concentration curves for calcium in uterus and aorta rings maintained in depolarizing nutritive solution. Moreover, addition of AlkF in calcium-free solution also reduces, in a concentration-dependent manner, the ability of caffeine and phenylephrine to contract aorta rings. This study reveals that the bark of Himatanthus lancifolius possesses one or more indole alkaloids able to alter non-vascular and vascular smooth muscle responsiveness, an event that may involve the blocking of calcium entry or changes on intracellular calcium utilization or mobilization.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Rattmann YD,Terluk MR,Souza WM,Santos CA,Biavatti MW,Torres LB,Mesia-Vela S,Rieck L,da Silva-Santos JE,Marques MC

doi

10.1016/j.jep.2005.02.041

keywords:

subject

Has Abstract

pub_date

2005-09-14 00:00:00

pages

268-75

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(05)00221-7

journal_volume

100

pub_type

杂志文章

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