Antihypertensive and vasorelaxant effects of aqueous extract from Croton schiedeanus Schlecht in rats.

Abstract:

:Antihypertensive and vasorelaxant effects of treatment with the aqueous extract of Croton schiedeanus Schlecht (AECS) were investigated in anaesthetized spontaneously hypertensive rats (SHR). Intravenous bolus injections of AECS (5-100 mg/kg) elicited dose-dependent decreases in mean arterial pressure (MAP) and heart rate (HR). Additionally, AECS (10(-6)-3x10(-3)g/ml) completely relaxed the contractions induced by high K(+) concentrations in intact rat aortic rings in a concentration-dependent manner.

journal_name

J Ethnopharmacol

authors

Guerrero MF,Carrón R,Martín ML,San Román L,Reguero MT

doi

10.1016/s0378-8741(00)00391-3

keywords:

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

33-6

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378874100003913

journal_volume

75

pub_type

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