当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Bioguided identification of triterpenoids and neolignans as bioactive compounds from anti-infectious medicinal plants of the Taira Atacama's community (Calama, Chile).

Bioguided identification of triterpenoids and neolignans as bioactive compounds from anti-infectious medicinal plants of the Taira Atacama's community (Calama, Chile).

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Previous ethnobotanical surveys from the north Andean part of Chile, where different ethnic groups are co-existing, with the preeminence of Aymara and Atacama traditions, revealed an extensive domestic use of the local flora. In these communities, traditional medicinal uses are mainly related to the treatment of respiratory, gastro-intestinal and urinary disorders, pain and inflammation, which is closely linked to epidemiological observations. AIM OF THE STUDY:As these symptoms may be related to infectious diseases, a bioguided evaluation of antibacterial and antifungal activity was conducted on eighteen species selected with the Taira community, in Ollague. MATERIALS AND METHODS:Screening was performed using a large panel of pathogenic germs involved in the main community acquired infectious diseases, represented by Gram positive and Gram negative bacteria of clinical interest and by human pathogenic fungi, using a bioguided approach. RESULTS AND CONCLUSIONS:Gram positive strains of clinical interest were highly sensitive to Aloysia deserticola (Verbenaceae) and Krameria lappacea (Krameriaceae) extracts. The bioguided approach led us to identify the isolated neolignan from K. lappacea conocarpan (1), and triterpenoids form A. deserticola (oleanolic acid (6) and ursolic acid (10)), as the main bioactive compounds.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Ortiz S,Lecsö-Bornet M,Bonnal C,Houze S,Michel S,Grougnet R,Boutefnouchet S

doi

10.1016/j.jep.2018.10.029

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

217-229

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(18)32608-4

journal_volume

231

pub_type

杂志文章

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