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In vitro anti-glycation activity of the marine plant Posidonia oceanica (L.) Delile.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:The marine plant Posidonia oceanica (L.) Delile is traditionally used by villagers of the west coast of Anatolia as a remedy for diabetes and hypertension. AIM OF THE STUDY:The aim of this study was to explore the role of the P. oceanica hydroalcoholic leaves extract (POE) against human serum albumin glycation. MATERIAL AND METHODS:Advanced glycation end products (AGEs) were obtained with the albumin-glucose in vitro assay. The AGEs intrinsic fluorescence intensity and the electrophoretic migration under native conditions allowed us to verify the effective glycation of albumin. The presence of POE during glycation process was intended to evaluate its anti-glycation role. RESULTS:POE exhibited a strong in vitro anti-glycation ability which occurred independently from its known antioxidant property. CONCLUSIONS:Overall, the antidiabetic, antioxidant, anti-inflammatory and anti-glycation properties of POE could be exploited as an effective tool against diabetes and related complications.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Vasarri M,Barletta E,Ramazzotti M,Degl'Innocenti D

doi

10.1016/j.jep.2020.112960

subject

Has Abstract

pub_date

2020-09-15 00:00:00

pages

112960

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(20)31336-2

journal_volume

259

pub_type

杂志文章

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