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Effects of Rubus coreanus on sperm parameters and cAMP-responsive element modulator (CREM) expression in rat testes.

Abstract：

:Rubi Fructus (RF), the dried, unripe fruit of Rubus coreanus M IQ. (Rosaceae), has been used to improve male reproductive function in traditional Korean medicine. In this study, we investigated the effects of RF on sperm parameters and expression of cAMP-responsive element modulator (CREM), which has a crucial role in spermatogenesis. RF was administered to 8-week-old male Wistar rats for 56 consecutive days (1.0 g/kg, daily, p.o.). Sperm analysis, RT-PCR, and Western blot assays were then carried out. The RF-treated animals showed significant increases in the weight of the testes, epididymal sperm count, and sperm motility compared to the control group. RF also increased the expression of CREM at both the mRNA and protein levels. These results suggest that RF may improve male fertility by enhancing spermatogenesis.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Oh MS,Yang WM,Chang MS,Park W,Kim DR,Lee HK,Kim WN,Park SK

doi

10.1016/j.jep.2007.08.025

subject

Has Abstract

pub_date

2007-12-03 00:00:00

pages

463-7

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(07)00416-3

journal_volume

114

pub_type

杂志文章

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