当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Pharmacokinetics comparative study of a novel Chinese traditional herbal formula and its compatibility.

Pharmacokinetics comparative study of a novel Chinese traditional herbal formula and its compatibility.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Da Chuan Xiong Decoction Compound preparation (DCXDCP), the formulation of a classical Chinese prescription recorded in "Xuanminglunfang", was clinically employed to treat migraine's disease. AIM OF THE STUDY:In order to investigate the influence of compatibility on the pharmacokinetics of the active ingredient gastrodin (GAS), the comparative evaluations on pharmacokinetics of DCXDCP with various combinations of its constituent herbs in plasma after oral administration were studied. MATERIALS AND METHODS:The rats were randomly assigned to four groups and orally administered with different prescription proportion of Gastrodia elata Bl. and Ligusticum chuanxiong Hort. (1:0; 1:0.25; 1:2.1; 1:4.2), respectively. At different predetermined time points after administration, the concentrations of GAS in rat plasma were determined by using HPLC, and main pharmacokinetic parameters were investigated. RESULTS:The results showed that the pharmacokinetic parameters, AUC and C(max) of GAS were dramatically different (p<0.05) after oral administration of G. elata Bl. and the different combinations of its constituent herbs. CONCLUSIONS:These indicated that the compatibility effects of other ingredients present in DCXDCP could affect the pharmacokinetics of the prescription.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Zheng Q,Yue PF,Wu B,Hu PY,Wu ZF,Yang M

doi

10.1016/j.jep.2011.05.007

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

221-5

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(11)00343-6

journal_volume

137

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Evaluation of the anti-inflammatory and analgesic activities of Liu-Shen-Wan and its individual fractions.

    abstract：:Liu-Shen-Wan (LSW), a famous traditional Chinese medicine for treatment of upper respiratory tract inflammation, was evaluated for its anti-inflammatory and analgesic activities. Acetic acid-elevated vascular permeability, carboxymethylcellulose sodium (CMC-Na)-induced leukocyte migration and ear edema induced by picr...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.02.008

    authors： Ma HY,Kou JP,Wang JR,Yu BY

    更新日期：2007-05-30 00:00:00

  • Huperzia saururus, activity on synaptic transmission in the hippocampus.

    abstract：:Huperzia saururus (Lam.) Trevis. (Lycopodiaceae) known as cola de quirquincho is used in folk medicine to improve memory. The cholinergic neurons of the basal forebrain, including those in the medial septum, and in the vertical limbs of the diagonal band of Broca and the nucleus basalis of Meynert, provide a major sou...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.11.002

    authors： Ortega MG,Vallejo MG,Cabrera JL,Pérez MF,Almirón RS,Ramírez OA,Agnese AM

    更新日期：2006-04-06 00:00:00

  • Shengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol diet.

    abstract：:Shengmai San (SMS), which is comprised of the medicinal herbs of Panax ginseng C.A. Meyer, Schisandra chinensis Baill., and Ophiopogon japonicus Ker-Gawl (2:1:2)., is a traditional Chinese medicine being used for treating coronary heart disease. The aim of this study was to investigate the effects of SMS on the plasma...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.10.043

    authors： Yao HT,Chang YW,Chen CT,Chiang MT,Chang L,Yeh TK

    更新日期：2008-02-28 00:00:00

  • Toxicity of Hydnora johannis Becca. dried roots and ethanol extract in rats.

    abstract：AIM OF THE STUDY:Hydnora johannis Becca. (Hydnoraceae) commonly is used for the treatment of dysentery, diarrhoea, cholera and swelling tonsillitis in the folk medicine of Sudan and other African countries. This study evaluates the toxicological effects of Hydnora johannis roots on Wistar rats. MATERIALS AND METHODS:R...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.06.044

    authors： Yagi S,Yagi AI,Gadir EH,Henry M,Chapleur Y,Laurain-Mattar D

    更新日期：2011-09-01 00:00:00

  • Nepeta angustifolia C. Y. Wu improves renal injury in HFD/STZ-induced diabetic nephropathy and inhibits oxidative stress-induced apoptosis of mesangial cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:As an important medicinal material constituting a variety of traditional Chinese medicine prescriptions, Nepeta angustifolia C. Y. Wu was used as a folk medicine to treat various vascular-related diseases including apoplexia, and cerebral haemorrhage in Tibet, China. Our previous studies ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112771

    authors： Huang S,Tan M,Guo F,Dong L,Liu Z,Yuan R,Dongzhi Z,Lee DS,Wang Y,Li B

    更新日期：2020-06-12 00:00:00

  • Preliminary results on the protective effect of (-)-edunol, a pterocarpan from Brongniartia podalyrioides (Leguminosae), against Bothrops atrox venom in mice.

    abstract：:(-)-Edunol a prenylated pterocarpan was isolated from the roots of two Mexican 'snakeweeds', Brongniartia podalyrioides and B. intermedia (Leguminosae). Edunol (3.1 mg/kg, i.p.) reduced the expected mortality of mice previously treated by the same route with the LD50 of the venom of the serpent Bothrops atrox. The mol...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(94)90086-8

    authors： Reyes-Chilpa R,Gómez-Garibay F,Quijano L,Magos-Guerrero GA,Ríos T

    更新日期：1994-05-01 00:00:00

  • Ethnomedicinal uses of Momordicacharantia (Cucurbitaceae) in Togo and relation to its phytochemistry and biological activity.

    abstract：:Investigation of the traditional uses of Momordica charantia (Cucurbitaceae) in Togo (West Africa) showed that it is one of the most important local medicinal plants both for ritual and ethnomedical practices. There was a high degree of consensus (>50%) for use in the treatment of gastrointestinal and viral disease am...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.08.009

    authors： Beloin N,Gbeassor M,Akpagana K,Hudson J,de Soussa K,Koumaglo K,Arnason JT

    更新日期：2005-01-04 00:00:00

  • Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic rats.

    abstract：:Aqueous, ethanolic and hexane fractions of Momordica cymbalaria fruits were prepared and given individually at different doses to different batches of rats (both normal and alloxan diabetic rats) after an overnight fast. The blood glucose levels were measured at 0, 1, 3, 5 and 7 h after the treatment. The aqueous extr...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00324-5

    authors： Rao BK,Kesavulu MM,Apparao C

    更新日期：2001-11-01 00:00:00

  • The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In traditional Chinese medicine, processed aconite root (lateral root of Aconitum carmichaelii Debx.) is used as the principle herb of the Si-Ni decoction (SND) formula due to its cardiotonic effect, while its cardiotoxicity and neurotoxicity caused by diester and monoester diterpenoid al...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.09.022

    authors： Zhang M,Peng Y,Wang M,Gao B,Zhao L,Li X

    更新日期：2019-01-10 00:00:00

  • The knowledge of medicinal plants in Africa today.

    abstract：:The oral tradition for communication in Africa is stressed as well as the secrecy of the treatments with plants by traditional medicine-men. This makes it difficult to obtain more exact information on all the different aspects of traditional medicine. Nevertheless, some data have been collected in the Francophone coun...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(80)90022-7

    authors： Lantum DN

    更新日期：1980-03-01 00:00:00

  • The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model.

    abstract：:Paeoniflorin and sinomenine, derived from the root of Paeonia lactiflora Pall. (family Ranunculaceae) and the stem of Sinomenium acutum Rehder & Wilson (family Menispermaceae), respectively, have been, and are currently, widely used for treatment of rheumatic and arthritic diseases in China and Japan. Our previous stu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.08.020

    authors： Chan K,Liu ZQ,Jiang ZH,Zhou H,Wong YF,Xu HX,Liu L

    更新日期：2006-02-20 00:00:00

  • Phellinus linteus inhibits inflammatory mediators by suppressing redox-based NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophage.

    abstract：:The mushroom Phellinus linteus has been known to exhibit potent biological activity. In contrast to the immuno-potentiating properties of Phellinus linteus, the anti-inflammatory properties of Phellinus linteus have rarely been investigated. Recently, ethanol extract and n-BuOH fractions from Phellinus linteus were de...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.08.011

    authors： Kim HG,Yoon DH,Lee WH,Han SK,Shrestha B,Kim CH,Lim MH,Chang W,Lim S,Choi S,Song WO,Sung JM,Hwang KC,Kim TW

    更新日期：2007-12-03 00:00:00

  • Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cyclocarya paliurus (CP) Batal., the sole species in its genus and native to China, is a herbal tea, which has been traditionally used in the folk medicine for the treatment of diabetes and hyperlipidemia in China. To evaluate the antihyperglycemic, antihyperlipidemic and antioxidant effe...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.10.040

    authors： Wang Q,Jiang C,Fang S,Wang J,Ji Y,Shang X,Ni Y,Yin Z,Zhang J

    更新日期：2013-12-12 00:00:00

  • Free radical scavenging activity of the alcoholic extract of Trewia polycarpa roots in arthritic rats.

    abstract：:The alcoholic extract of Trewia polycarpa roots (TPE), which exhibited significant anti-inflammatory activity, was evaluated for the possible mode of action by studying its antioxidant potential in adjuvant-induced arthritic rats. The biological defence system constituting the superoxide dismutase, glutathione peroxid...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00143-0

    authors： Chamundeeswari D,Vasantha J,Gopalakrishnan S,Sukumar E

    更新日期：2003-09-01 00:00:00

  • The composition and vascular/antioxidant properties of Taraxacum officinale flower water syrup in a normal-fat diet using an obese rat model.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Taraxacum officinale (L.), commonly called dandelion has been used for centuries as a natural medicine to treat inflammatory diseases including some metabolic alterations associated with obesity. AIM OF THE STUDY:Based on animal experiments this study aims to explore the potential mechan...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113393

    authors： Majewski M,Lis B,Juśkiewicz J,Ognik K,Jedrejek D,Stochmal A,Olas B

    更新日期：2021-01-30 00:00:00

  • Chemical constituents and bioactivity of Piper sarmentosum.

    abstract：:Eight amides, pellitorine (1), guineensine (2), brachystamide B (3), sarmentine (4), brachyamide B (5), 1-piperettyl pyrrolidine (6), 3',4',5'-trimethoxycinnamoyl pyrrolidine (7) and sarmentosine (8), two lignans, (+)-asarinin (9) and sesamin (10), and four other compounds, 1-(3,4-methylenedioxyphenyl)-1E-tetradecene ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.01.022

    authors： Rukachaisirikul T,Siriwattanakit P,Sukcharoenphol K,Wongvein C,Ruttanaweang P,Wongwattanavuch P,Suksamrarn A

    更新日期：2004-08-01 00:00:00

  • Some phytochemical aspects of medicinal plant research.

    abstract：:Various aspects of medicinal plant research, i.e. collection of data, screening for biological activity and isolation and identification of active compounds are briefly discussed with special reference to phytochemical aspects. Based upon this some topics for further methodological research are presented. A strategy f...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0378-8741(89)90044-5

    authors： Verpoorte R

    更新日期：1989-02-01 00:00:00

  • Pro-angiogenic activity of Tongnao decoction on HUVECs in vitro and zebrafish in vivo.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Tongnao Decoction (TND) is a Chinese decoction approved and used in Jiangsu Province Hospital for the treatment of ischemic stroke. It shows conclusive efficiency in the improvement of neurologic impairment and activities of daily living of the patients. AIM OF THE STUDY:Recently, angiog...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112737

    authors： Wang J,Zhang XH,Xu X,Zhu Q,Yao B,Liang S,Chen Z,Wang Y,He MF,Wu M

    更新日期：2020-05-23 00:00:00

  • Efficacy and safety of Pueraria candollei var. mirifica (Airy Shaw & Suvat.) Niyomdham for menopausal women: A systematic review of clinical trials and the way forward.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Pueraria candollei var. mirifica (Airy Shaw & Suvat.) Niyomdham (commonly termed P. mirifica, PM) growing in upland Thailand has a long history as a postmenopausal rejuvenant therapy for indigenants. Its amelioration of menopause symptoms in clinical trials was assessed. MATERIALS AND ME...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2018.01.028

    authors： Kongkaew C,Scholfield NC,Dhippayom T,Dilokthornsakul P,Saokaew S,Chaiyakunapruk N

    更新日期：2018-04-24 00:00:00

  • Pharmacological evaluation of Alstonia scholaris: anti-tussive, anti-asthmatic and expectorant activities.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Alstonia scholaris (Apocynaceae) was documented as an effective herb for the treatment of chronic respiratory diseases in "dai" ethnopharmacy historically, and its leaf crude extract, used for releasing tracheitis and cold symptom, was approved to be a commercial formulation by State Food...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.03.029

    authors： Shang JH,Cai XH,Zhao YL,Feng T,Luo XD

    更新日期：2010-06-16 00:00:00

  • The effect of Compound Danshen Dripping Pills, a Chinese herb medicine, on the pharmacokinetics and pharmacodynamics of warfarin in rats.

    abstract：AIM OF THE STUDY:Significant pharmacokinetic/pharmacodynamic (PK/PD) interactions between various herbal products and warfarin have recently been reported. The present study was conducted to determine whether Compound Danshen Dripping Pills (CDDP), a Chinese herb medicine used for the treatment of cardiovascular diseas...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.08.035

    authors： Chu Y,Zhang L,Wang XY,Guo JH,Guo ZX,Ma XH

    更新日期：2011-10-11 00:00:00

  • An integrated study of metabolomics and transcriptomics to reveal the anti-primary dysmenorrhea mechanism of Akebiae Fructus.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Akebiae Fructus, a Tujia minority folk medicine and a well-known traditional Chinese medicine for soothing the liver, regulating Qi, promoting blood circulation and relieving pain, is widely used in the treatment of primary dysmenorrhea. However, little is known about its underlying mecha...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113763

    authors： Ma B,Yang S,Tan T,Li J,Zhang X,Ouyang H,He M,Feng Y

    更新日期：2020-12-28 00:00:00

  • Antimicrobial and anti-inflammatory activity of folklore: Mallotus peltatus leaf extract.

    abstract：:Since ages Mallotus peltatus (Geist) Muell. Arg. var acuminatus (Euphorbiaceae) leaf and stem bark is used in folk medicine to cure intestinal ailments and skin infections. In several intestinal ailments, localized inflammation is of common occurrence and hence we have evaluated the antimicrobial as well as anti-infla...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00165-4

    authors： Chattopadhyay D,Arunachalam G,Mandal AB,Sur TK,Mandal SC,Bhattacharya SK

    更新日期：2002-10-01 00:00:00

  • Qingxue jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-κB signaling pathways.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Qingxue jiedu Formulation (QF) is composed of two classic prescriptions which have been clinically used for more than 5 centuries and appropriately modified through basic theory of traditional Chinese medicine for treating various skin inflammation such as atopic dermatitis (AD), acute de...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113773

    authors： Xiong X,Huang C,Wang F,Dong J,Zhang D,Jiang J,Feng Y,Wu B,Xie T,Cheng L

    更新日期：2020-12-31 00:00:00

  • LC-MS characterized methanolic extract of zanthoxylum armatum possess anti-breast cancer activity through Nrf2-Keap1 pathway: An in-silico, in-vitro and in-vivo evaluation.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Zanthoxylum armatum DC (Rutaceae) containing flavonoids, alkaloids, coumarins, lignans, amides and terpenoid is well-known for its curative properties against various ailments including cancer. In the current research, phytochemicals present in the methanolic extract of Zanthoxylum armatu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113758

    authors： Sahu R,Kar RK,Sunita P,Bose P,Kumari P,Bharti S,Srivastava S,Pattanayak SP

    更新日期：2021-04-06 00:00:00

  • The medicinal uses of Callicarpa L. in traditional Chinese medicine: an ethnopharmacological, phytochemical and pharmacological review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Callicarpa L. (Verbenaceae) has been used for centuries in Traditional Chinese Medicine (TCM) for the prevention and treatment of a wide number of health disorders such as inflammation, rheumatism, hematuria, fracture, hematemesis, menoxenia, gastrointestinal bleeding, scrofula, etc. AIM...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2012.12.051

    authors： Tu Y,Sun L,Guo M,Chen W

    更新日期：2013-03-27 00:00:00

  • Dahuang Fuzi Decoction ameliorates tubular epithelial apoptosis and renal damage via inhibiting TGF-β1-JNK signaling pathway activation in vivo.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Dahuang Fuzi Decoction (DFD) is a traditional well-prescribed formula for the treatment of chronic kidney disease (CKD) in China. This study was carried out to examine the effects of DFD in adenine-induced tubular epithelial apoptosis and renal damage, in comparison with allopurinol (AP),...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.08.035

    authors： Tu Y,Sun W,Wan YG,Gao K,Liu H,Yu BY,Hu H,Huang YR

    更新日期：2014-10-28 00:00:00

  • Danggui Buxue Tang promotes the adhesion and migration of bone marrow stromal cells via the focal adhesion pathway in vitro.

    abstract：ETHNOPHARMACOLOGY RELEVANCE:Danggui Buxue Tang has been used in China to treat clinical anemia for more than 800 years. However, there is no scientific report on its effect on bone marrow stromal cells. AIM OF THE STUDY:Here, we aimed to explore the effect of Danggui Buxue Tang on bone marrow stromal cell adhesion and...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.11.018

    authors： Bo H,He J,Wang X,Du R,Bei H,Chen J,Wang J,Wu F,Zhang W,Chen Q

    更新日期：2019-03-01 00:00:00

  • Cantharis by photosynthetic bacteria biotransformation: Reduced toxicity and improved antitumor efficacy.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The blister beetle, also known as Mylabris cichorii, is not only widely used in clinical applications in Chinese anticancer medicine, but is also one of the main ingredients in a variety of traditional Chinese medicinal preparations with anticancer activity. However, the strong toxicity e...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.03.058

    authors： Yu M,Zhao Y

    更新日期：2016-06-20 00:00:00

  • Metabolomics profiling reveals Echinops latifolius Tausch improves the trabecular micro-architecture of ovariectomized rats mainly via intervening amino acids and glycerophospholipids metabolism.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Echinops latifolius Tausch (ELT) is traditional Mongolian medicine in China, and often used to against osteoporosis, strengthen tendons and bones, clear bones heat. AIM OF THE STUDY:To study efficacy of ELT on ovariectomized (OVX) rats and underly metabolic pathways related to trabecular...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113018

    authors： Wang J,Dong X,Ma F,Li C,Bu R,Lu J,Gao J,Xue P

    更新日期：2020-10-05 00:00:00