Abstract:
:Huperzia saururus (Lam.) Trevis. (Lycopodiaceae) known as cola de quirquincho is used in folk medicine to improve memory. The cholinergic neurons of the basal forebrain, including those in the medial septum, and in the vertical limbs of the diagonal band of Broca and the nucleus basalis of Meynert, provide a major source of cholinergic enervation of the cortex and hippocampus. These neurons have also been shown to play an important role in learning and memory processes. Thus, the effects of this traditional Argentinean species were studied in relation to its activity on synaptic transmission in the hippocampus. The alkaloid extract obtained first by decoction of the aerial parts and by subsequent alkaline extraction, was purified by using a Sephadex LH 20 packed column. Electrophysiological experiments were developed with the purified extract (E(2)) on rat hippocampus slices, thus eliciting long-term potentiation (LTP). Results show a marked increase in the hippocampal synaptic plasticity. The threshold value for generation of LTP was 22 +/- 1.01 Hz on average for E(2), while for controls it was 86 +/- 0.92 Hz. All of these factors could explain the use of Huperzia saururus as a memory improver as is reported in the ethnomedicine.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Ortega MG,Vallejo MG,Cabrera JL,Pérez MF,Almirón RS,Ramírez OA,Agnese AMdoi
10.1016/j.jep.2005.11.002keywords:
subject
Has Abstractpub_date
2006-04-06 00:00:00pages
374-8issue
3eissn
0378-8741issn
1872-7573pii
S0378-8741(05)00741-5journal_volume
104pub_type
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