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Huperzia saururus, activity on synaptic transmission in the hippocampus.

Abstract：

:Huperzia saururus (Lam.) Trevis. (Lycopodiaceae) known as cola de quirquincho is used in folk medicine to improve memory. The cholinergic neurons of the basal forebrain, including those in the medial septum, and in the vertical limbs of the diagonal band of Broca and the nucleus basalis of Meynert, provide a major source of cholinergic enervation of the cortex and hippocampus. These neurons have also been shown to play an important role in learning and memory processes. Thus, the effects of this traditional Argentinean species were studied in relation to its activity on synaptic transmission in the hippocampus. The alkaloid extract obtained first by decoction of the aerial parts and by subsequent alkaline extraction, was purified by using a Sephadex LH 20 packed column. Electrophysiological experiments were developed with the purified extract (E(2)) on rat hippocampus slices, thus eliciting long-term potentiation (LTP). Results show a marked increase in the hippocampal synaptic plasticity. The threshold value for generation of LTP was 22 +/- 1.01 Hz on average for E(2), while for controls it was 86 +/- 0.92 Hz. All of these factors could explain the use of Huperzia saururus as a memory improver as is reported in the ethnomedicine.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Ortega MG,Vallejo MG,Cabrera JL,Pérez MF,Almirón RS,Ramírez OA,Agnese AM

doi

10.1016/j.jep.2005.11.002

keywords:

subject

Has Abstract

pub_date

2006-04-06 00:00:00

pages

374-8

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(05)00741-5

journal_volume

104

pub_type

杂志文章

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