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Antinociceptive and hypnotic properties of Celastrus orbiculatus.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Celastrus orbiculatus, a woody vine of the Celastraceae family, has been widely used as a traditional medicine for the treatment of many diseases, including rheumatoid arthritis and odontalgia. In this study, we assessed the sedative and antinociceptive activities of the methanolic extract of Celastrus orbiculatus (MCO). MATERIALS AND METHODS:The antinociceptive effect of MCO was evaluated using several experimental pain models, including thermal nociception methods, such as the tail immersion and the hotplate tests, as well as chemical nociception induced by intraperitoneal acetic acid and subplantar formalin administration in mice. To verify the possible connection of the opioid receptor to the antinociceptive activity of MCO, we performed a combination test with naloxone, a nonselective opioid receptor antagonist. The sedative effect of MCO was studied using the pentobarbital-induced sleeping model. RESULTS:MCO demonstrated strong and dose-dependent antinociceptive activity compared to tramadol and indomethacin in various experimental pain models. The combination test using naloxone revealed that the antinociceptive activity of MCO is associated with activation of the opioid receptor. MCO also caused decreased sleep latency and increased sleeping time in the pentobarbital-induced sleeping model; however, MCO alone did not induce sleep. CONCLUSIONS:In the present study, MCO showed potent antinociceptive and sedative activities. Based on these results, MCO may be considered a valuable anti-nociceptive and hypnotic agent for the treatment of various diseases.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Park HJ,Cha DS,Jeon H

doi

10.1016/j.jep.2011.07.052

subject

Has Abstract

pub_date

2011-10-11 00:00:00

pages

1240-4

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(11)00528-9

journal_volume

137

pub_type

杂志文章

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