Dragon's Blood extract has antithrombotic properties, affecting platelet aggregation functions and anticoagulation activities.

Abstract:

ETHNOPHARMACOLOGICAL RELEVANCE:Dragon's Blood from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China), as a traditional Chinese medicinal herb, was shown to have certain antithrombotic effects. A new preparation process was used to extract effective components from Dragon's Blood. A 95% ethanol extract A (EA) and a precipitate B (PB) fraction were obtained and compared. Reliability of the preparation process was validated by pharmacodynamic experiments. MATERIALS AND METHODS:A rat/mouse thrombosis and blood stasis model was developed for this study, and EA and PB effects on thrombosis, platelet functions and blood coagulation activities were analyzed. RESULTS:It was observed that the EA fraction had significantly better inhibitory effects than the PB fraction on thrombosis (p<0.05), platelet aggregation function (p<0.01) and anticoagulation activity (p<0.05-0.01). CONCLUSIONS:The results obtained here showed that EA fraction from Dragon's Blood contained pharmacologically effective compounds with antithrombotic effects, partially improving platelet function and anticoagulation activity.

journal_name

J Ethnopharmacol

authors

Xin N,Li YJ,Li Y,Dai RJ,Meng WW,Chen Y,Schlappi M,Deng YL

doi

10.1016/j.jep.2011.03.063

subject

Has Abstract

pub_date

2011-05-17 00:00:00

pages

510-4

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(11)00214-5

journal_volume

135

pub_type

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