当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Cytotoxicity and modes of action of five Cameroonian medicinal plants against multi-factorial drug resistance of tumor cells.

Cytotoxicity and modes of action of five Cameroonian medicinal plants against multi-factorial drug resistance of tumor cells.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Beilschmiedia acuta Kosterm, Clausena anisata (Willd) Hook, Fagara tessmannii Engl., Newbouldia laevis Seem., and Polyscias fulva (Hiern) Harms. are medicinal plants used in Cameroonian traditional medicine in the treatment of various types of cancers. The present study aims at investigating 11 methanolic extracts from the above Cameroonian medicinal plants on a panel of human cancer cell lines, including various drug-resistant phenotypes. Possible modes of action were analyzed for two extracts from Beilschmiedia acuta and Polyscia fulva and alpha-hederin, the representative constituent of Polyscia fulva. MATERIALS AND METHODS:Cytotoxicity was determined using a resazurin assay. Cell cycle, apoptosis, mitochondrial membrane potential (MMP), and reactive oxygen species (ROS) were measured by flow cytometry. Cellular response to alpha-hederin was investigated by a mRNA microarray approach. RESULTS:Prescreening of extracts (40µg/mL) showed that three of eleven plant extracts inhibited proliferation of CCRF-CEM cells by more than 50%, i.e. BAL (73.65%), the bark extract of Beilschmiedia acuta (78.67%) and PFR (68.72%). Subsequent investigations revealed IC50 values below or around 30µg/mL of BAL and PFR in 10 cell lines, including drug-resistant models, i.e. P-glycoprotein-overexpressing CEM/ADR5000, breast cancer resistance protein-transfected MDA-MB-231-BCRP, TP53 knockout cells (HCT116 p53(-/-)), and mutation-activated epidermal growth factor receptor-transfected U87MG.ΔEGFR cells. IC50 values below 5µg/mL of BAL were obtained for HCT116 (p53(-/-)) cells. IC50 values below 10µM of alpha-hederin were found for sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 cells. The BAL and PFR extracts induced cell cycle arrest between G0/G1 and S phases. PFR-induced apoptosis was associated with increased ROS generation and MMP breakdown. Microarray-based cluster analysis revealed a gene expression profile that predicted cellular response to alpha-hederin. CONCLUSION:BAL, PFL and alpha-hederin, an exemplarily taken constituent of Beilschmiedia acuta and Polyscia fulva extracts revealed cytotoxicity towards cancer cell lines. Hence, Beilschmiedia acuta and Polyscia fulva may be valuable to develop drugs against otherwise drug-resistant cancer cells.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Kuete V,Tankeo SB,Saeed ME,Wiench B,Tane P,Efferth T

doi

10.1016/j.jep.2014.02.025

subject

Has Abstract

pub_date

2014-04-11 00:00:00

pages

207-19

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(14)00138-X

journal_volume

153

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Analysis of traditional knowledge for wild edible mushrooms consumed by residents living in Jirisan National Park (Korea).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:This study aims to record and analyze the traditional knowledge of wild edible mushrooms utilized by residents living in Jirisan National Park (Korea). MATERIALS AND METHODS:Data was collected through participant observations and in-depth interviews with semi-structured questionnaires. Q...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.12.041

    authors： Kim H,Song MJ

    更新日期：2014-04-11 00:00:00

  • Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice.

    abstract：:Melissa officinalis L. (Labiatae), Morus alba L. (Moraceae), and Artemisia capillaris Thunb. (Compositae) are suggested to be involved in the regulation of hyperlipidemia. We hypothesized that Ob-X, a mixture of three herbs, Morus alba, Melissa officinalis and Artemisia capillaris [corrected] improves lipid metabolism...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.09.029

    authors： Lee J,Chae K,Ha J,Park BY,Lee HS,Jeong S,Kim MY,Yoon M

    更新日期：2008-01-17 00:00:00

  • Effects of hydroethanolic extracts of Balanites aegyptiaca (L.) Delile (Balanitaceae) on some resistant pathogens bacteria isolated from wounds.

    abstract：BACKGROUND:The bark of Balanites aegyptiaca (L.) Delile (Balanitaceae) is widely used in the Togolese folk medicine for the treatment of wounds, malaria and skin diseases. This study aimed to evaluate the antioxidant properties and the activity of the bark extract of this plant against some resistant bacteria isolated ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.01.051

    authors： Anani K,Adjrah Y,Ameyapoh Y,Karou SD,Agbonon A,de Souza C,Gbeassor M

    更新日期：2015-04-22 00:00:00

  • Oligosaccharidic fractions derived from Triticum vulgare extract accelerate tissutal repairing processes in in vitro and in vivo models of skin lesions.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Triticum vulgare has been extensively used in traditional medicine thanks to its properties of accelerating tissue repair. The aqueous extract of Triticum vulgare (TVE) is currently an active component used by Farmaceutici Damor in the manufacture of certain pharmaceutical products alread...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.10.051

    authors： Sanguigno L,Minale M,Vannini E,Arato G,Riccio R,Casapullo A,Monti MC,Riccio R,Formisano S,Di Renzo G,Cuomo O

    更新日期：2015-01-15 00:00:00

  • Ethnomedicinal survey and in vitro anti-plasmodial activity of the palm Borassus aethiopum Mart.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Malaria remains a major global health threat, with the heaviest burden of disease in sub-Saharan Africa. Effective treatment is not available in many affected areas, and the Plasmodium falciparum parasite is becoming resistant to existing drugs. Alternative therapies are necessary to over...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.09.010

    authors： Gruca M,Yu W,Amoateng P,Nielsen MA,Poulsen TB,Balslev H

    更新日期：2015-12-04 00:00:00

  • Screening for antimicrobial activity of crude drug extracts and pure natural products from Mexican medicinal plants.

    abstract：:Preliminary antimicrobial screening against Candida albicans and selected Gram-positive and Gram-negative bacteria of methanol extracts prepared from eight Mexican medicinal plants, noted for their antiseptic properties, was conducted. The significant activity exhibited for extracts of Ratibida latipalearis, Teloxys g...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(92)90025-m

    authors： Rojas A,Hernandez L,Pereda-Miranda R,Mata R

    更新日期：1992-01-01 00:00:00

  • Antihyperglycemic and insulin secretory activity of Costus pictus leaf extract in streptozotocin induced diabetic rats and in in vitro pancreatic islet culture.

    abstract：AIM OF THE STUDY:The leaves of Costus pictus D. Don were used extensively for its antihyperglycemic activity by the people in Kerala, India. In the present study, the antihyperglycemic and insulin secretory activity of an aqueous extract of Costus pictus leaf extract was investigated in streptozotocin induced diabetic ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.03.026

    authors： Gireesh G,Thomas SK,Joseph B,Paulose CS

    更新日期：2009-06-25 00:00:00

  • Bioguided identification of triterpenoids and neolignans as bioactive compounds from anti-infectious medicinal plants of the Taira Atacama's community (Calama, Chile).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Previous ethnobotanical surveys from the north Andean part of Chile, where different ethnic groups are co-existing, with the preeminence of Aymara and Atacama traditions, revealed an extensive domestic use of the local flora. In these communities, traditional medicinal uses are mainly rel...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.10.029

    authors： Ortiz S,Lecsö-Bornet M,Bonnal C,Houze S,Michel S,Grougnet R,Boutefnouchet S

    更新日期：2019-03-01 00:00:00

  • Nitrite oxide and inducible nitric oxide synthase were regulated by polysaccharides isolated from Glycyrrhiza uralensis Fisch.

    abstract：:Water-soluble polysaccharide(Glycyrrhiza polysaccharide, GP) was isolated from Glycyrrhiza uralensis Fisch, with glycosidic units were composed of alpha (1-4) linked D-glucana. We demonstrated that GP significantly induces nitric oxides (NO) production and inducible NO synthase (iNOS) transcription in peritoneal macro...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.03.002

    authors： Cheng A,Wan F,Jin Z,Wang J,Xu X

    更新日期：2008-06-19 00:00:00

  • Zingansikpoongtang modulates beta-amyloid and IL-1beta-induced cytokine production and cyclooxygenase-2 expression in human astrocytoma cells U373MG.

    abstract：:Zingansikpoongtang (ZST) is a Korean herbal prescription, which has been successfully applied for the various neurodegenerative diseases. However, its effect remains unknown in the experimental models. In this study, we examined the effect of ZST on production of interleukin (IL)-6 and IL-8, and expression of cyclooxy...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.09.021

    authors： Kim SJ,Jeong HJ,Lee KM,Ryu HH,Lee KS,Moon BS,Cho KH,Kim HM

    更新日期：2005-01-04 00:00:00

  • Pharmacological basis for the medicinal use of muskmelon base (Pedicellus Melo.) for abdominal distention and constipation.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Muskmelon base (Pedicellus Melo.) has a long history (Ming Dynasty) as a Chinese traditional medicine. According to traditional use, it was prepared as rectal suppositories for treating abdominal distention and constipation. The present study was carried out on the pharmacological basis f...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.04.025

    authors： Gao Y,Cai RL,Xie C,Lin YL,Zhang L,Qi Y

    更新日期：2012-06-26 00:00:00

  • Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet region (Province of Errachidia), Morocco.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:We carried out an ethnobotanical survey in Tafilalet region. This region is classified by the UNESCO as a reserve of biosphere and represents an important area with important knowledge of traditional medicine, especially the use of medicinal plants for human healthcare. Furthermore, the g...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.12.017

    authors： Eddouks M,Ajebli M,Hebi M

    更新日期：2017-02-23 00:00:00

  • The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Gongjin-Dan is a representative traditional Oriental medicine herbal drug that has been used to treat chronic fatigue symptoms for several hundred years. We evaluated the anti-fatigue effects of Gongjin-Dan and the underlying mechanisms in a chronic forced exercise mouse model. METHODS A...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.04.001

    authors： Hong SS,Lee JY,Lee JS,Lee HW,Kim HG,Lee SK,Park BK,Son CG

    更新日期：2015-06-20 00:00:00

  • Cytotoxic and genotoxic effects of defence secretion of Ulomoides dermestoides on A549 cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ulomoides dermestoides (Fairmaire, 1893) is a cosmopolitan tenebrionid beetle reared by Argentine people who consume them alive as an alternative medicine in the treatment of different illnesses such as asthma, Parkinson's, diabetes, arthritis, HIV and specially cancer. AIM OF THE STUDY:...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.04.056

    authors： Crespo R,Villaverde ML,Girotti JR,Güerci A,Juárez MP,de Bravo MG

    更新日期：2011-06-14 00:00:00

  • Involvement of mTOR/Survivin signaling pathway in TUA(2β, 3β, 23-trihydroxy-urs-12-ene-28-olic acid)-induced apoptosis in human gastric cancer cell line BGC823 cells.

    abstract：ETHNO-PHARMACOLOGICAL RELEVANCE:A natural ursolic compound, 2β,3β,23-trihydroxy-urs-12-ene-28-olic acid (TUA) was isolated from the root of Actinidiafulvicoma Hance. (A.fulvicoma Radix), which is used as a traditional hebal medicine to cure innominate inflammation of unknown origin of the digestive tract in the She nat...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113437

    authors： Cheng Q,Li Y,Guo X,Li H

    更新日期：2021-03-01 00:00:00

  • Ethno-pharmacological insulin signaling induction of aqueous extract of Syzygium paniculatum fruits in a high-fat diet induced hepatic insulin resistance.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The ethnopharmacological significance of the fruits of Syzygium paniculatum Gaertn (Magenta Cherry) is widely recognized in the Indian traditional medicine system to treat various disorders, such as diabetes, hyperlipidaemia, hypertension, and cardiovascular problems. AIM OF THE STUDY:Th...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113576

    authors： Konda PY,Chennupati V,Dasari S,Sharma N,Muthulingam M,Ramakrishnan R,Sade A,Jagadheeshkumar V,Natesan V,Jaiswal KK

    更新日期：2021-03-25 00:00:00

  • Anti-inflammatory activity of Euphorbia acaulis Roxb.

    abstract：:From various extracts of Euphorbia acaulis , the n-hexane fraction showed marked anti-inflammatory activity in carrageenan induced oedema in rats and mice as compared to phenylbutazone and was equipotent in adrenal- ectomised rats. In chronic models of formaldehyde and adjuvant arthritis, its anti-arthritic activity w...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(84)90004-7

    authors： Singh GB,Kaur S,Satti NK,Atal CK,Maheshweri JK

    更新日期：1984-04-01 00:00:00

  • Studies on the luteolytic, oestrogenic and follicle-stimulating hormone like activity of plant Rhaphidophora pertusa (Roxb.).

    abstract：:The phytochemical, pharmacological and toxicological feature of plant Rhaphidophora pertusa (Roxb.) was done. Phytosteroids, flavonoids, tannins and glucosides were detected in the plant extracts. In cross-bred (Zebu X Holstein-Friesian or Jersey) dairy cows, subsequent to prostaglandin (PG) induced oestrus, to each g...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.03.036

    authors： Santhosh CR,Shridhar NB,Narayana K,Ramachandra SG,Dinesh S

    更新日期：2006-10-11 00:00:00

  • Anxiolytic effect of a herbal medicine, yokukansan, in aged rats: involvement of serotonergic and dopaminergic transmissions in the prefrontal cortex.

    abstract：AIM OF THE STUDY:Aging is thought to affect emotions including anxiety, and a herbal medicine, yokukansan (YKS), is used to treat emotional disturbances associated with age-related neurodegenerative disorders such as Alzheimer's disease, but its pharmacological properties have not been fully understood. The present stu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.09.048

    authors： Mizoguchi K,Tanaka Y,Tabira T

    更新日期：2010-01-08 00:00:00

  • Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models.

    abstract：AIMS OF THE STUDY:This study was to investigate the gastrokinetic activity of Morinda citrifolia aqueous fruit extract (AFE) in human subjects by examining the GI absorption of ranitidine, a putative indicator of GI motility and to elucidate its possible gastrokinetic mechanism of action in rats. MATERIALS AND METHODS...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jep.2012.04.044

    authors： Nima S,Kasiwong S,Ridtitid W,Thaenmanee N,Mahattanadul S

    更新日期：2012-07-13 00:00:00

  • Mechanism by which ma-xing-shi-gan-tang inhibits the entry of influenza virus.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ma-xing-shi-gan-tang (MXSGT, aka maxing shigan powder), a Chinese herbal decoction, has been used for the treatment of the common cold, fever, and influenza virus infections. However, the underlying mechanisms of its activity against the influenza virus are not fully understood. In this s...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.05.061

    authors： Hsieh CF,Lo CW,Liu CH,Lin S,Yen HR,Lin TY,Horng JT

    更新日期：2012-08-30 00:00:00

  • Some phytochemical aspects of medicinal plant research.

    abstract：:Various aspects of medicinal plant research, i.e. collection of data, screening for biological activity and isolation and identification of active compounds are briefly discussed with special reference to phytochemical aspects. Based upon this some topics for further methodological research are presented. A strategy f...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0378-8741(89)90044-5

    authors： Verpoorte R

    更新日期：1989-02-01 00:00:00

  • Labisia pumila var. alata reduces bacterial load by inducing uroepithelial cell apoptosis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Labisia pumila var. alata (LPva) is a traditional medicinal herb used by Malaysian women to treat many ailments of the genitourinary tract. Its phytoestrogenic properties suggest potential to prevent recurrent urinary tract infection (UTI) in women post menopause. The aim of this study wa...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.04.018

    authors： Fazliana M,Ramos NL,Lüthje P,Sekikubo M,Holm A,Wan Nazaimoon WM,Brauner A

    更新日期：2011-06-14 00:00:00

  • Anti-inflammatory effect of Cortex Eucommiae via modulation of the toll-like receptor 4 pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages.

    abstract：ETHNOPHARMOCOLOGICAL RELEVANCE:Cortex Eucommiae (CE), the bark of Eucommia ulmoides Oliv., has been traditionally used for its kidney-tonifying and bone- and tendon-enhancing properties in Korea, China, and Japan. CE has been historically prescribed for inflammatory conditions such as arthritis of the knee and ankle. ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.08.001

    authors： Koh W,Shin JS,Lee J,Lee IH,Lee SK,Ha IH,Chung HJ

    更新日期：2017-09-14 00:00:00

  • Various uses of the castor oil plant (Ricinus communis L.). A review.

    abstract：:The ancient and modern medicinal uses of the castor bean plant, Ricinus communis L. (Euphorbiaceae), in about fifty countries worldwide, has been surveyed. The different medicinal uses are grouped separately in relation to their pharmacological action, whether real or presumed, within the various medical specialties. ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0378-8741(82)90038-1

    authors： Scarpa A,Guerci A

    更新日期：1982-03-01 00:00:00

  • Panax notoginseng saponins inhibit ischemia-induced apoptosis by activating PI3K/Akt pathway in cardiomyocytes.

    abstract：AIM OF THIS STUDY:The panax notoginseng saponins (PNS) have been clinically used for the treatment of cardiovascular diseases and stroke in China. Evidences demonstrated that PNS could protect cardiomyocytes from injury induced by ischemia, but the underlying molecular mechanisms of this protective effect are still unc...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.05.011

    authors： Chen S,Liu J,Liu X,Fu Y,Zhang M,Lin Q,Zhu J,Mai L,Shan Z,Yu X,Yang M,Lin S

    更新日期：2011-09-01 00:00:00

  • Inhibition of glucose-induced vascular endothelial growth factor expression by Salvia miltiorrhiza hydrophilic extract in human microvascular endothelial cells: evidence for mitochondrial oxidative stress.

    abstract：AIM OF STUDY:Diabetes mellitus is frequently combined with vascular diseases, which are associated with the expression of vascular endothelial growth factor (VEGF). An approach that can reverse the induction of VEGF by hyperglycemia may potentially benefit the outcome of diabetic patients. Therefore, in the present stu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.07.018

    authors： Qian S,Huo D,Wang S,Qian Q

    更新日期：2011-09-02 00:00:00

  • Hepatoprotective activity of flavonoids from Cichorium glandulosum seeds in vitro and in vivo carbon tetrachloride-induced hepatotoxicity.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cichorium glandulosum Boiss. et Huet was used historically in Uyghur folk medicine. Its roots, seeds, and aerial parts are extensively used by Uyghur residents in Xinjiang to eliminate savda typhoid, dredge and cure obstructive jaundice variety liver disorders. AIM OF THE STUDY:To evalua...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.08.045

    authors： Tong J,Yao X,Zeng H,Zhou G,Chen Y,Ma B,Wang Y

    更新日期：2015-11-04 00:00:00

  • Screening of seven selected Rwandan medicinal plants for antimicrobial and antiviral activities.

    abstract：:Aqueous EtOH (80%) extracts of seven plants used by Rwandan traditional healers to treat infections, were screened for antibacterial, antifungal, and antiviral activities. Only two of the selected plants showed a true antiviral activity against herpes simplex virus type 1, while all of them exhibited virucidal propert...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(98)00154-8

    authors： Sindambiwe JB,Calomme M,Cos P,Totté J,Pieters L,Vlietinck A,Vanden Berghe D

    更新日期：1999-04-01 00:00:00

  • Identification of the toxic constituents in Rhizoma Coptidis.

    abstract：AIM OF THE STUDY:Rhizoma Coptidis (Huanglian) is a widely used Traditional Chinese Medicine. However, it causes human as well as animal toxicities. In this study, we aimed to ascertain the toxic constituents in Rhizoma Coptidis. MATERIALS AND METHODS:The acute toxicity of both the total extract and the alkaloid-rich e...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.01.047

    authors： Ma BL,Ma YM,Shi R,Wang TM,Zhang N,Wang CH,Yang Y

    更新日期：2010-03-24 00:00:00