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Olea europaea leaf extract exerts L-type Ca(2+) channel antagonistic effects.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:In Southern Europe Olea europaea leafs are known as a folk remedy for hypertension. Cardiovascular diseases are still the leading causes of morbidity and mortality in industrialized countries with hypertension being one of the main risk factors. AIM OF THE STUDY:We investigated effects of a commercial Olea europaea leaf extract (OLE) on isolated hearts and cultured cardiomyocytes. MATERIALS AND METHODS:Isolated rabbit hearts were perfused according to the Langendorff technique and connected to a 256-channel epicardial mapping system. Voltage clamp experiments were performed in cultured neonatal rat cardiomyocytes using a perforated-patch technique. RESULTS:OLE caused a concentration-depended decrease in systolic left ventricular pressure and heart rate as well as an increase in relative coronary flow and a slight, but not significant prolongation of PQ-time. There were no significant changes between the groups in the activation-recovery interval and its dispersion, total activation time, peak-to-peak amplitude, percentage of identical breakthrough-points and similar vectors of local activation. Voltage clamp experiments in cultured neonatal rat cardiomyocytes showed a significant decrease in maximum I(Ca,L) by OLE which was reversible upon wash-out. CONCLUSIONS:OLE suppresses the L-type calcium channel directly and reversibly. Our findings might help to understand the traditional use of OLE in the treatment of cardiovascular disease.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Scheffler A,Rauwald HW,Kampa B,Mann U,Mohr FW,Dhein S

doi

10.1016/j.jep.2008.08.018

subject

Has Abstract

pub_date

2008-11-20 00:00:00

pages

233-40

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(08)00458-3

journal_volume

120

pub_type

杂志文章

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