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Effect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxis.

Abstract：

:We studied the effect of Acanthopanax senticosus stem (ACPS) on mast cell-dependent anaphylaxis. ACPS inhibited compound 48/80-induced systemic anaphylaxis at a dose of 1.0 g/kg by 50%. ACPS also inhibited passive cutaneous anaphylaxis reaction and histamine release from mast cells in a dose-dependent manner, respectively. Moreover, ACPS had an inhibitory effect on anti-dinitrophenyl IgE-induced tumor necrosis factor-alpha (TNF-alpha) production from mast cells. These results indicate that ACPS inhibits mast cell-mediated anaphylaxis in vivo and in vitro murine model.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Yi JM,Hong SH,Kim JH,Kim HK,Song HJ,Kim HM

doi

10.1016/s0378-8741(01)00403-2

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

347-52

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378874101004032

journal_volume

79

pub_type

杂志文章

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