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Antihepatotoxic actions of gingerols and diarylheptanoids.

Abstract：

:The antihepatotoxic effects of gingerols, shogaols, diarylheptanoids and related analogues were assessed utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most congeners exhibited significant actions in these assay methods. The carbon tetrachloride assay appeared to be most useful in defining structure-activity relationships. The antihepatotoxic activity of gingerols and shogaols was dependent on the length of the side chain with the [7]- and [8]-companions eliciting the strongest activity. The gingerols exerted more intense activity than the corresponding shogaols. In the diarylheptanoids, introduction of hydroxyl groupings on the phenyl rings caused increased activity; however, the effect of the positions and number of hydroxyls on activity was variable depending on the carbon skeleton.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Hikino H,Kiso Y,Kato N,Hamada Y,Shioiri T,Aiyama R,Itokawa H,Kiuchi F,Sankawa U

doi

10.1016/0378-8741(85)90025-x

subject

Has Abstract

pub_date

1985-09-01 00:00:00

pages

31-9

issue

1

eissn

0378-8741

issn

1872-7573

pii

0378-8741(85)90025-X

journal_volume

14

pub_type

杂志文章

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