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Antifungal activity of some coumarins obtained from species of Pterocaulon (Asteraceae).

Abstract：

:Fractionation of antifungal hexane extracts of the aerial parts of three Pterocaulon spp., Pterocaulon alopecuroides, Pterocaulon balansae and Pterocaulon polystachyum (Asteraceae) from South Brazil traditionally used to treat animal mycoses, afforded the coumarins 5-methoxy-6,7-methylenedioxycoumarin, 7-(2',3'-epoxy-3'-methylbutyloxy)-6-methoxycoumarin, 6,7-methylenedioxycoumarin (ayapin), along with a mixture of 6-hydroxy-7-(3'-methylbutyl-2'-en-oxy)-coumarin (prenyletin) and 6-methoxy-7-(3'-methylbutyl-2'-en-oxy)-coumarin (prenyletin-methyl-ether). Among the different components of the active extracts, only the mixture of prenyletin and prenyletin-methyl-ether isolated from Pterocaulon polystachyum showed activity against Cryptococcus neoformans, Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes. Nevertheless their MIC values were higher than the MIC of the original extracts, suggesting that the mixture but not only one compound would be the responsible for the activity detected in these Pterocaulon species.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Stein AC,Alvarez S,Avancini C,Zacchino S,von Poser G

doi

10.1016/j.jep.2006.02.009

keywords:

subject

Has Abstract

pub_date

2006-08-11 00:00:00

pages

95-8

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(06)00090-0

journal_volume

107

pub_type

杂志文章

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