当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Traditional Chinese medicine Bao Gan Ning increase phosphorylation of CREB in liver fibrosis in vivo and in vitro.

Traditional Chinese medicine Bao Gan Ning increase phosphorylation of CREB in liver fibrosis in vivo and in vitro.

Abstract：

:Previous studies have demonstrated that traditional Chinese medicine Bao Gan Ning, which contains six different drugs: Trionyx sinensis Wiegmann shell, Prunus persica (L.) Batsch seed, Salvia miltiorrhiza Bge. root, Mallotus opelta (Lour.) Muell-Arg root, Astragalus membranaceus (Fisch.) Bge. var. mongho-licus (Bge.) Hsiao root and Scutellaria baicalensis Georgi root, was able to protect liver against fibrosis in CCL4 models. In an effort to elucidate molecular mechanisms by which Bao Gan Ning exerts its anti-fibrosis activity, effects of Bao Gan Ning on liver fibrosis and cAMP response element binding protein (CREB), an important transcription factor involved in liver fibrosis, were evaluated in animal and cell models in this work. Results showed that Bao Gan Ning (2.16 or 4.32 g/kg/day) significantly decreased alanine aminotransferase (ALT) and hyaluronidase levels and reversed liver fibrosis in rat liver fibrosis models. The proliferation of HSC-T6, a hepatic stellate cell line, was also significantly inhibited by incubation with serums that were prepared from rats fed with Bao Gan Ning. Most interestingly, results from Western blot, immunohistochemistry and electrophoretic mobility shift assay (EMSA) showed that Bao Gan Ning up-regulated CREB phosphorylation both in rat liver fibrosis models and in HSC-T6 cells, but did not affect protein level of CREB and the DNA binding activity of CREB. These results suggested that up-regulation of CREB phosphorylation may be involved in anti-fibrosis activity of Chinese medicine Bao Gan Ning.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Tan Y,Lv ZP,Bai XC,Liu XY,Zhang XF

doi

10.1016/j.jep.2005.09.040

keywords:

subject

Has Abstract

pub_date

2006-04-21 00:00:00

pages

69-75

issue

1-2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(05)00672-0

journal_volume

105

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Nitrite oxide and inducible nitric oxide synthase were regulated by polysaccharides isolated from Glycyrrhiza uralensis Fisch.

    abstract：:Water-soluble polysaccharide(Glycyrrhiza polysaccharide, GP) was isolated from Glycyrrhiza uralensis Fisch, with glycosidic units were composed of alpha (1-4) linked D-glucana. We demonstrated that GP significantly induces nitric oxides (NO) production and inducible NO synthase (iNOS) transcription in peritoneal macro...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.03.002

    authors： Cheng A,Wan F,Jin Z,Wang J,Xu X

    更新日期：2008-06-19 00:00:00

  • The pharmacy of the Benedictine monks: the use of medicinal plants in Northeast Brazil during the nineteenth century (1823-1829).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The health of nineteenth century Brazilians is only alluded to in historical documents, and researchers still have much to discover. AIM OF THE STUDY:This study aims to show the medicinal plants used in the 19th century in Brazil. MATERIALS AND METHODS:To this end, information was obtai...

    journal_title：Journal of ethnopharmacology

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.jep.2011.11.014

    authors： Medeiros MF,de Albuquerque UP

    更新日期：2012-01-06 00:00:00

  • Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats.

    abstract：AIM OF THE STUDY:In the present study, we investigated the effects of Kangen-karyu, a traditional Chinese prescription comprising six herbs, on diabetes. MATERIALS AND METHODS:Kangen-karyu extract (50, 100, or 200mg/kg body weight) was administered to streptozotocin (STZ)-induced diabetic rats and serum and hepatic bi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.04.032

    authors： Kim HY,Okamoto T,Yokozawa T

    更新日期：2009-07-15 00:00:00

  • Integrative serum metabolomics and network analysis on mechanisms exploration of Ling-Gui-Zhu-Gan Decoction on doxorubicin-induced heart failure mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ling-Gui-Zhu-Gan Decoction (LGZGD) formula, derived from traditional Chinese medicine (TCM), has definitive clinical efficacy in the treatment of heart failure (HF) in China. However, little is known of the underlying mechanism of LGZGD. AIM OF THE STUDY:The aim of this work was to inves...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112397

    authors： Wang X,Gao Y,Tian Y,Liu X,Zhang G,Wang Q,Xie W,Liu K,Qian Q,Wang Q

    更新日期：2020-03-25 00:00:00

  • Antinociceptive activity of extracts and secondary metabolites from wild growing and micropropagated plants of Renealmia alpinia.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Renealmia alpinia is native to the American continent and can be found from Mexico to Brazil, and in the Caribbean islands. It is known as "matandrea" in Colombia, and it has been commonly used in traditional medicine to treat painful diseases and ailments. Based on its traditional uses, ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.02.012

    authors： Gómez-Betancur I,Cortés N,Benjumea D,Osorio E,León F,Cutler SJ

    更新日期：2015-05-13 00:00:00

  • Garcinia kola aqueous suspension prevents cerebellar neurodegeneration in long-term diabetic rat - a type 1 diabetes mellitus model.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The development of compounds able to improve metabolic syndrome and mitigate complications caused by inappropriate glycemic control in type 1 diabetes mellitus is challenging. The medicinal plant with established hypoglycemic properties Garcinia kola Heckel might have the potential to mit...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.11.001

    authors： Farahna M,Seke Etet PF,Osman SY,Yurt KK,Amir N,Vecchio L,Aydin I,Aldebasi YH,Sheikh A,Chijuka JC,Kaplan S,Adem A

    更新日期：2017-01-04 00:00:00

  • Effect of a herbal protein, CI-1, isolated from Cajanus indicus on immune response of control and stressed mice.

    abstract：:The effect of a herbal protein, CI-1, purified from the leaves of Cajanus indicus was evaluated as a probable immunomodulator on immune response in control and stressed mice. In mice, sensitized with sheep red blood cells (SRBC), CI-1 enhanced IgG level by 28% over control (P < 0.05). Primary and secondary antibody re...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(99)00046-x

    authors： Datta S,Sinha S,Bhattacharyya P

    更新日期：1999-11-30 00:00:00

  • Traditional medicine in Turkey. IV. Folk medicine in the Mediterranean subdivision.

    abstract：:The traditional utilization of plants as medicine in the Mediterranean region has been investigated. Field surveys were carried out among the people who live in the Taurus Mountains. Sixty-nine medicinal plants have been identified, which are listed with the vernacular names, the parts used, the methods of preparing t...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(93)90048-a

    authors： Yeşilada E,Honda G,Sezik E,Tabata M,Goto K,Ikeshiro Y

    更新日期：1993-05-01 00:00:00

  • Inhibitory activity of Jatropha multifida latex on classical complement pathway activity in human serum mediated by a calcium-binding proanthocyanidin.

    abstract：:This study isolates and characterizes the anti-complement constituent(s) present in the latex of Jatropha multifida, in an attempt to explain the traditional application of the latex in the treatment of infected wounds. Guided by the inhibition of classical pathway (CP) complement activity in human serum, a polymer wa...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(89)90080-9

    authors： Kosasi S,Hart LA,van Dijk H,Labadie RP

    更新日期：1989-11-01 00:00:00

  • Puerarin attenuates glutamate-induced neurofilament axonal transport impairment.

    abstract：AIM OF THE STUDY:Puerarin (Pur) is a primary component of the most functional extracts of Pueraria lobata used in traditional Chinese medicine for centuries. Since it has been postulated that Pur protects the brain against glutamate (Glu) neurotoxicity, we investigated the effects of Pur on Glu-induced axonal transport...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.08.005

    authors： Zhou J,Wang H,Xiong Y,Li Z,Feng Y,Chen J

    更新日期：2010-10-28 00:00:00

  • Protection of mouse brain from paracetamol-induced stress by Centella asiatica methanol extract.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Centella asiatica (CA) is a medicinal herb traditionally used as a brain tonic in Ayurvedic medicine. Various ethnomedical leads revealed the effective use of CA in the treatment of symptoms associated to oxidative stress and inflammation. AIM OF THE STUDY:The aim of this study was to ev...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.03.017

    authors： Viswanathan G,Dan VM,Radhakrishnan N,Nair AS,Rajendran Nair AP,Baby S

    更新日期：2019-05-23 00:00:00

  • In vivo bioactivity assessment on Epilobium species: A particular focus on Epilobium angustifolium and its components on enzymes connected with the healing process.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Epilobium species are generally known as "Yakı Otu" in Turkey, which mens "plaster herb" in English. Young shoots of Epilobium angustifolium L., Epilobium stevenii Boiss., and Epilobium hirsutum L. are consumed as salad or meal. These species have been used as a poultice for the treatment...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113207

    authors： Karakaya S,Süntar I,Yakinci OF,Sytar O,Ceribasi S,Dursunoglu B,Ozbek H,Guvenalp Z

    更新日期：2020-11-15 00:00:00

  • Cancer chemopreventive activity of compounds isolated from Waltheria indica.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Waltheria indica L. is traditionally used in several countries against inflammatory related diseases and cancer, mainly as a decoction of the aerial parts. AIM OF THE STUDY:The transcription factor NF-κB is known to induce tumor promotion and progression and is considered a major player ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.03.048

    authors： Monteillier A,Cretton S,Ciclet O,Marcourt L,Ebrahimi SN,Christen P,Cuendet M

    更新日期：2017-05-05 00:00:00

  • Evaluation of the protective potential of Artemisia maritima extract on acetaminophen- and CCl4-induced liver damage.

    abstract：:The hepatoprotective activity of the aqueous-methanolic extract of Artemisia maritima was investigated against acetaminophen (paracetamol, 4-hydroxy acetanilide)- and carbon tetrachloride (CCl4)-induced hepatic damage. Acetaminophen produced 100% mortality at the dose of 1 g/kg in mice, while pretreatment of animals w...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(95)01252-9

    authors： Janbaz KH,Gilani AH

    更新日期：1995-06-23 00:00:00

  • Antimicrobial activity of Eucalyptus camaldulensis essential oils and their interactions with conventional antimicrobial agents against multi-drug resistant Acinetobacter baumannii.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Traditional herbal medicine has become an important issue on the global scale during the past decade. Among drugs of natural origin, special place belongs to essential oils, known as strong antimicrobial agents that can be used to combat antibiotic-resistant bacteria. Eucalyptus camaldule...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.12.008

    authors： Knezevic P,Aleksic V,Simin N,Svircev E,Petrovic A,Mimica-Dukic N

    更新日期：2016-02-03 00:00:00

  • Wenshen Zhuanggu formula mitigates breast cancer bone metastasis through the signaling crosstalk among the Jagged1/Notch, TGF-β and IL-6 signaling pathways.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Advanced breast cancer frequently metastasizes to the bone, resulting in patient morbidity and mortality. The interaction of tumor cells with osteoclasts and osteoblasts seriously affects the occurrence and development of bone metastasis in breast cancer. The signaling crosstalk among the...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.12.023

    authors： Wu C,Chen M,Sun Z,Ye Y,Han X,Qin Y,Liu S

    更新日期：2019-03-25 00:00:00

  • The antioxidant activity of Chinese herbs for eczema and of placebo herbs--I.

    abstract：:A standardized mixture of Chinese herbs has recently been demonstrated to be an effective treatment for chronic atopic eczema in placebo controlled trials in the UK. Aqueous decoctions of this formulated mixture (PSE 222), the placebo mixture, and their component herbs were examined for antioxidant activity to determi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(97)01510-9

    authors： Kirby AJ,Schmidt RJ

    更新日期：1997-04-01 00:00:00

  • Evaluation of anti-diarrhoeal activity in seed extracts of Mangifera indica.

    abstract：:Mangifera indica is commonly grown in many parts of the world. Its seeds have been used for anti-diarrhoeal activity in Indian traditional medicine. This study evaluates the potential anti-diarrhoeal activity of methanolic (MMI) and aqueous (AMI) extracts of seeds of M. indica in experimental diarrhoea, induced by cas...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00250-7

    authors： Sairam K,Hemalatha S,Kumar A,Srinivasan T,Ganesh J,Shankar M,Venkataraman S

    更新日期：2003-01-01 00:00:00

  • Mechanisms involved in the gastroprotective activity of Celtis iguanaea (Jacq.) Sargent on gastric lesions in mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Celtis iguanaea (Canabaceae) is popularly known as esporão-de-galo, stands out among the medicinal plants used for treatment of gastric ulcers. In Brazil, the leaves they are used traditionally in infusion forms as an analgesic, antiasthmatic, digestive and diuretic. AIM OF THE STUDY:The...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.08.006

    authors： Martins JL,Rodrigues OR,da Silva DM,Galdino PM,de Paula JR,Romão W,da Costa HB,Vaz BG,Ghedini PC,Costa EA

    更新日期：2014-09-29 00:00:00

  • Brine shrimp toxicity and antiplasmodial activity of five Kenyan medicinal plants.

    abstract：:The organic extracts of leaves and roots of five plants used for treating malaria in Central, Nairobi and Rift Valley Provinces, Kenya were tested for brine shrimp lethality and in vitro antiplasmodial activity against chloroquine sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 60% were...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.09.047

    authors： Wanyoike GN,Chhabra SC,Lang'at-Thoruwa CC,Omar SA

    更新日期：2004-01-01 00:00:00

  • Studies on the mechanism of action of Semecarpus anacardium in rheumatoid arthritis.

    abstract：:Semecarpus anacardium nuts are used for variety of disorders in Ayurveda. A chloroform extract of the nut significantly reduced acute carrageenan-induced paw oedema in rats and was active against the secondary lesions of adjuvant-induced arthritis. Delayed hypersensitivity induced in mice by sheep red blood cells as a...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(89)90017-2

    authors： Saraf MN,Ghooi RB,Patwardhan BK

    更新日期：1989-04-01 00:00:00

  • Efficacy of inhaled Lavandula angustifolia Mill. Essential oil on sleep quality, quality of life and metabolic control in patients with diabetes mellitus type II and insomnia.

    abstract：ETHNOPHARMACOLOGIC RELEVANCE:Lavandula angustifolia Mill (lavender) odor was traditionally used as sleep enhancer. Previous studies have shown interaction between insomnia, quality of life and control of diabetes mellitus (DM). Insomnia is suggested to increase the risk of depression and decrease the quality of life in...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112560

    authors： Nasiri Lari Z,Hajimonfarednejad M,Riasatian M,Abolhassanzadeh Z,Iraji A,Vojoud M,Heydari M,Shams M

    更新日期：2020-04-06 00:00:00

  • Panax quinquefolium saponins inhibited immune maturation of human monocyte-derived dendritic cells via blocking nuclear factor-κB pathway.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Panax quinquefolium saponins (PQS), a water-soluble antioxidant extracted from a natural herb, radix panacis quinquefolii (American Ginseng), has yielded encouraging results in the treatment of atherosclerotic diseases. However, the underlying mechanisms remain unclear. Here, we tested th...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.03.029

    authors： Liu H,Shi D,Wang W,Zhang C,Fu M,Ge J

    更新日期：2012-06-14 00:00:00

  • The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens.

    abstract：:Extracts from Helichrysum aureonitens are used topically by the indigenous people of South Africa against infections. The antimicrobial activity-guided fractionation by bioautography of the acetone extract from the aerial parts of H. aureonitens led to the isolation of 3,5,7-trihydroxyflavone (galangin). Evaluation of...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(97)00065-2

    authors： Afolayan AJ,Meyer JJ

    更新日期：1997-08-01 00:00:00

  • Neuroprotection, learning and memory improvement of a standardized extract from Renshen Shouwu against neuronal injury and vascular dementia in rats with brain ischemia.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The Renshen Shouwu capsule (RSSW) is a patented Traditional Chinese Medicine (TCM), that has been proven to improve memory and is widely used in China to apoplexy syndrome and memory deficits. To investigate the neuroprotective and therapeutic effect of the Renshen Shouwu standardized ext...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.02.027

    authors： Wan L,Cheng Y,Luo Z,Guo H,Zhao W,Gu Q,Yang X,Xu J,Bei W,Guo J

    更新日期：2015-05-13 00:00:00

  • Triterpenoids from the genus Gynostemma: Chemistry and pharmacological activities.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:G. pentaphyllum, also known as Jiao-Gu-Lan, has been used traditionally as folk remedies for many diseases, including diabetes mellitus, metabolic syndrome, aging, and neurodegenerative diseases in China and some countries in East and Southeast Asia. It is considered as an "immortality he...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2020.113574

    authors： Nguyen NH,Ha TKQ,Yang JL,Pham HTT,Oh WK

    更新日期：2021-03-25 00:00:00

  • Antihypertensive action of a procyanidin glycoside from Rhamnus lycioides.

    abstract：:The antihypertensive action of a procyanidin glycoside isolated from Rhamnus lycioides aerial parts was studied in spontaneously and renal hypertensive rats. This compound, like 20 micrograms/kg i.v. of captopril, produced a very clear in vivo inhibition of angiotensin I converting enzyme when given at a dose of 3 mg/...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(91)90149-8

    authors： Terencio MC,Sanz MJ,Paya M

    更新日期：1991-01-01 00:00:00

  • Evaluation of anti-diarrhoeal and anti-ulcerogenic potential of ethanol extract of Carpolobia lutea leaves in rodents.

    abstract：:The effect of ethanol extract of Carpolobia lutea leaves on experimentally induced diarrhoea and ulcers was studied in rodents. The extract (245-735 mg/kg) inhibited small intestinal transit time (15.10-45.03%), castor oil-induced diarrhoea (25.69-43.54%) and fluid accumulation (7.53-34.15%), respectively, as well as ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.01.019

    authors： Nwafor PA,Bassey AI

    更新日期：2007-05-22 00:00:00

  • Phytochemical screening of a Warao pharmacopoeia employed to treat gastrointestinal disorders.

    abstract：:A three-year medical-ethnobotanical investigation among the Warao of the Orinoco Delta in eastern Venezuela documented a pharmacopoeia of 100 plant species representing 45 families. Warao phytotherapists manipulate these plants in diverse manners to produce 259 remedies of various complexities to treat 52 classes of d...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(91)90183-e

    authors： Wilbert W,Haiek G

    更新日期：1991-08-01 00:00:00

  • Modulome-Fangjiome Association Study (MoFAS) Reveals Differential Target Distribution among Four Similar Fangjis (Formulas).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Precise target distribution is a key issue for further appreciate applications of fangjis (formulas) with similar efficacy and herbal constituents to maximize efficacy and minimize toxicity. AIM OF THE STUDY:To develop an algorithm for investigating the differential target distributions ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2021.113822

    authors： Wang P,Zhou W,Liu J,Sui F,Wang Z

    更新日期：2021-01-15 00:00:00