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Evaluation of anti-diarrhoeal and anti-ulcerogenic potential of ethanol extract of Carpolobia lutea leaves in rodents.

Abstract：

:The effect of ethanol extract of Carpolobia lutea leaves on experimentally induced diarrhoea and ulcers was studied in rodents. The extract (245-735 mg/kg) inhibited small intestinal transit time (15.10-45.03%), castor oil-induced diarrhoea (25.69-43.54%) and fluid accumulation (7.53-34.15%), respectively, as well as indomethancin (47.64-79.79%) and ethanol-induced (65.63-89.65%) ulcer models. The various degrees of inhibitions were statistically significant (p < 0.001). The phytochemical screening confirmed the presence of tannins, saponins and flavonoids. Others include cardiac glycosides, anthraquinones and terpenes. The median lethal dose (LD50) was determined to be 2449.49 mg/kg body weight. Though the mechanism of action of the extract may not be fully understood, the extract may in part be mediating its actions through its inhibitory effects on alpha2-adrenoceptor and cholinergic (anti-muscarinic receptor) systems or through the actions of its active metabolites.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Nwafor PA,Bassey AI

doi

10.1016/j.jep.2007.01.019

subject

Has Abstract

pub_date

2007-05-22 00:00:00

pages

619-24

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(07)00030-X

journal_volume

111

pub_type

杂志文章

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