Abstract:
:Centaurea phyllocephala Boiss. has been used in folkloric medicine as an antidiabetic agent. Present investigations on various extracts of C. phyllocephala revealed that basal plasma glucose concentration and plasma glucose response to glucose load were either elevated or unchanged by the i.v. administration of these extracts in anaesthetized rats or by i.p. or oral administration of the extracts in conscious rats. The predominant effect of C. phyllocephala is the toxicity in rats and mice and this indicates the presence of some toxic or active compounds which merit phytochemical isolation. Further, C. phyllocephala extracts also caused either an initial brief hypotension followed by a delayed hypertension or produced no changes when injected i.v. in the rats. The hypotensive effect was inhibited by atropine whereas the hypertensive effect was prevented by phentolamine or guanethidine but not by hexamethonium. The alcoholic extract also induced an initial brief negative inotropic effect, followed by delayed prolonged positive inotropic and negative chronotropic effects on the spontaneous inotropic and negative chronotropic effects on the spontaneous contractions of the guinea pig right atrium. The initial depressing effect and the delayed positive inotropic effect were inhibited by pretreatment with atropine. The extract of C. phyllocephala also produced a contractile activity on guinea pig ileum strips and this could be prevented by atropine. No significant diuretic effect was produced by the extract. Phytochemical screening revealed that C. phyllocephala contains tertiary and quaternary alkaloids, sesquiterpene lactones, methylated flavones and their glycosides, as well as leuco- and proanthocyanidines. Further studies on sesquiterpene lactones and methylated flavones resulted in the isolation of lactones with alpha-methylene gamma-lactone and methylene side chain on the cyclopentyl ring as well as of four methylated flavones (hispidulin, nepetin, cirsiliol, jaceosidin) structurally closely related to the cytotoxic flavonoids of other Compositae plants.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Twaij HA,Kery A,Al-Khazraji NKdoi
10.1016/0378-8741(83)90037-5subject
Has Abstractpub_date
1983-12-01 00:00:00pages
299-314issue
2-3eissn
0378-8741issn
1872-7573pii
0378-8741(83)90037-5journal_volume
9pub_type
杂志文章abstract:AIM OF THE STUDY:Huang-Lian-Jie-Du-Tang (HLJDT) is a traditional Chinese medicine with anti-inflammatory use. In the present study, the effects of its component herbs and pure components were observed on eicosanoid generation to find out the contributory components and their precise targets on arachidonic acid (AA) cas...
journal_title:Journal of ethnopharmacology
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更新日期:2011-05-17 00:00:00
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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更新日期:2002-10-01 00:00:00
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journal_title:Journal of ethnopharmacology
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更新日期:2006-04-21 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The ethanolic extract of Lychnophora trichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and inflammatory diseases. AIM OF THE STUDY:The present study aimed at investigating whether ethanolic extract of L. trichocarpha, its ethyl acetate fraction and its main bi...
journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2020-05-23 00:00:00
abstract:AIM OF THE STUDY:Despite the extensive traditional use of Croton gratissimus Burch. var. gratissimus for medicinal purposes, scientific studies validating the therapeutic properties of this indigenous plant are lacking. As the bark, roots and leaves of C. gratissimus are used separately as well as in combination, this ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2008.06.031
更新日期:2008-10-28 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2014-02-03 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2007-03-21 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2015-04-22 00:00:00
abstract:AIM OF THE STUDY:Mitragyna speciosa Korth from Rubiaceae family is a tropical plant indigenous to Southeast Asia particularly in Thailand, Peninsular of Malaysia and Indonesia. The leaves have been used by natives for their opium-like effect and cocaine-like stimulant ability to combat fatigue and enhance tolerance to ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2010.03.036
更新日期:2010-06-16 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2019-07-15 00:00:00
abstract:AIM OF THE STUDY:Artemisia vestita is a common traditional Tibetan medicinal plant which has been used widely in China for treating various inflammatory diseases. Since little is known about its active components, the purpose of this study was to isolate and identify the immunosuppressive compounds from Artemisia vesti...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2008.07.029
更新日期:2008-10-30 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/0378-8741(94)90019-1
更新日期:1994-03-01 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2013.10.039
更新日期:2013-12-12 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2010-07-20 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2017-09-14 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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更新日期:1993-05-01 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2018-05-23 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2013-06-21 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2017-05-23 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2013-10-28 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2011-11-18 00:00:00
abstract::Paepalantine is an isocoumarin isolated from Paepalanthus vellozioides which showed antimicrobial activity in in vitro experiments. In the present study, paepalantine was tested for possible clastogenic and cytotoxic action. Cultures from different individuals were treated with paepalantine at concentrations of 20, 40...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:1999-12-15 00:00:00
abstract::Laghupatha (Cissampelos pareira) a important medicinal plant in Indian traditional system of medicine and is widely used in many countries by different tribal. Despite the wide use of Cissampelos pareira in folk medicine, no study has been published in the scientific literature about its toxicological profile. In pres...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2008-03-28 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The presence of nitrite in the human diet was thought to constitute a hazard as secondary nitrosamines are known to cause gastric cancers. MATERIALS AND METHODS:Recent publications on the physiology of serum nitrite have been consulted. PROBLEMS:Nitrite is added to some foodstuffs as an...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2014.09.040
更新日期:2015-06-05 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Ganoderma lucidum Polysaccharide (GLP),traditional Chinese medicine (TCM) active ingredient, has a long history and has good curative effects on radiation injury. However, the mechanism of GLP treating radiation injury has not been clearly elucidated. THE AIM OF THE STUDY:This study was ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2020.112814
更新日期:2020-08-10 00:00:00