当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers.

Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers.

Abstract：

:Although pharmacokinetic alternations by hepatic injury have been extensively studied, little is known about the potential influence of hepatoprotective agent's treatment. This study was aimed to investigate the holistic pharmacokinetics of multiple lignans, CYP3A regulations, and their correlations with hepatic injury biomarkers, in hepatic injured rats pretreated with or without schisandra lignan extract (SLE) and dimethyl-diphenyl-bicarboxylate (DDB). Integral pharmacokinetics of multiple lignans based on an AUC-weighting approach was determined in normal, CCl4 induced hepatic injury rats pretreated with or without SLE and DDB. Protein expression and activities of CYP3A were determined. Pharmacokinetic parameters and CYP3A activities were correlated with serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. CCl4 induced acute hepatic injury resulted in a nearly 8-fold enhancement of integral plasma exposures of multiple lignans, which was caused by the significant down-regulation of CYP3A. SLE and DDB pretreatment exhibited potent hepatoprotective effects, accompanied with the restored expression and activity of CYP3A, and the recovery of the respective and integral pharmacokinetics of lignans components. The integral AUC(0-tn) and CYP3A activities correlated well with ALT and AST. This study suggested that the pharmacokinetic regulating effects of hepatoprotective agent's on themselves and co-prescribed drugs should be of concern, and hepatic injury biomarkers may serve as good predictors.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Xie Y,Hao H,Kang A,Liang Y,Xie T,Sun S,Dai C,Zheng X,Xie L,Li J,Wang G

doi

10.1016/j.jep.2010.06.038

subject

Has Abstract

pub_date

2010-09-15 00:00:00

pages

290-9

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(10)00454-X

journal_volume

131

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Study on the increment of the production of gastric mucus in rats treated with Opuntia ficus indica (L.) Mill. cladodes.

    abstract：:Opuntia ficus indica cladodes are used in traditional medicine of many countries for their cicatrisant activity. The major components of cladodes are carbohydrate-containing polymers, which consist of a mixture of mucilage and pectin. In this paper we studied the cytoprotective effects of cladodes on experimental etha...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00243-x

    authors： Galati EM,Pergolizzi S,Miceli N,Monforte MT,Tripodo MM

    更新日期：2002-12-01 00:00:00

  • Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat.

    abstract：:This study sought to examine the antihypertensive mechanism of garlic in two-kidney-one-clip (2K1C) hypertensive rat. In this study, the effect of garlic on serum and tissue including: aorta, heart, kidney, lung as well as circulatory (serum) ACE activity in 2K1C rats were examined. Four groups of rats were selected: ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00080-1

    authors： Sharifi AM,Darabi R,Akbarloo N

    更新日期：2003-06-01 00:00:00

  • Oral Uncaria rhynchophylla (UR) reduces kainic acid-induced epileptic seizures and neuronal death accompanied by attenuating glial cell proliferation and S100B proteins in rats.

    abstract：AIM OF THE STUDY:Epilepsy is a common clinical syndrome with recurrent neuronal discharges in cerebral cortex and hippocampus. Here we aim to determine the protective role of Uncaria rhynchophylla (UR), an herbal drug belong to Traditional Chinese Medicine (TCM), on epileptic rats. MATERIALS AND METHODS:To address thi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.03.018

    authors： Lin YW,Hsieh CL

    更新日期：2011-05-17 00:00:00

  • Toxicity and potential anti-trypanosomal activity of ethanolic extract of Azadirachta indica (Maliacea) stem bark: an in vivo and in vitro approach using Trypanosoma brucei.

    abstract：AIM OF THE STUDY:To determine the toxicity and anti-trypanosomal activity of the ethanolic extract of Azadirachta indica (Maliacea) stem bark, through in vivo and in vitro approach using Trypanosoma brucei brucei. MATERIALS AND METHODS:Graded concentrations (100, 200, 400, 800, 1600 and 3200 mg/kg) of the crude stem b...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.01.013

    authors： Mbaya AW,Ibrahim UI,God OT,Ladi S

    更新日期：2010-03-24 00:00:00

  • One man's poison, another man's medicine?

    abstract：:Poisonous plants and animals are widespread in nature and have been used for a great variety of purposes. Brief discussions of a number of examples: aconite, ergot, Euphorbiaceae/Thymelaeaceae, curare, cardiac glycosides, triterpenoid saponins and animal toxins, make the point that, in addition to allowing their use a...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0378-8741(91)90105-m

    authors： Bisset NG

    更新日期：1991-04-01 00:00:00

  • Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models.

    abstract：AIMS OF THE STUDY:This study was to investigate the gastrokinetic activity of Morinda citrifolia aqueous fruit extract (AFE) in human subjects by examining the GI absorption of ranitidine, a putative indicator of GI motility and to elucidate its possible gastrokinetic mechanism of action in rats. MATERIALS AND METHODS...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jep.2012.04.044

    authors： Nima S,Kasiwong S,Ridtitid W,Thaenmanee N,Mahattanadul S

    更新日期：2012-07-13 00:00:00

  • Nyctanthes arbor-tristis Linn--a critical ethnopharmacological review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Nyctanthes arbor-tristis (Oleaceae) is a mythological plant; has high medicinal values in Ayurveda. The popular medicinal use of this plant are anti-helminthic and anti-pyretic besides its use as a laxative, in rheumatism, skin ailments and as a sedative. Vitally, the natives plant it in ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2013.01.024

    authors： Agrawal J,Pal A

    更新日期：2013-04-19 00:00:00

  • The effects of Sceletium tortuosum in an in vivo model of psychological stress.

    abstract：AIM OF THE STUDY:Sceletium, and especially Sceletium tortuosum, is traditionally used as masticator and thought to have a sedative effect which may be beneficial to reduce symptoms of anxiety and/or depression. The current study evaluated the scientific merit of these anecdotal claims in an in vivo model of psychologic...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.08.058

    authors： Smith C

    更新日期：2011-01-07 00:00:00

  • The water expelling effect evaluation of 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol and ingenol on H22 mouse hepatoma ascites model and their content differences analysis in Euphorbia kansui before and after stir-fried with vinegar by UPLC.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Malignant ascites (MA) effusion is mainly caused by hepatocellular, ovarian, and breast cancer etc. It has been reported that Euphorbia kansui (EK), the root of Euphorbia kansui S.L.Liou ex S.B.Ho, possessing a therapeutic effect on MA. However, the clinical applications of EK are serious...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113507

    authors： Zhang Q,Ju YH,Zhang Y,Wang K,Zhang M,Chen PD,Yao WF,Tang YP,Wu JH,Zhang L

    更新日期：2021-03-01 00:00:00

  • Withanolides from Whitania aristata and their diuretic activity.

    abstract：AIM OF THE STUDY:Withania aristata is an endemic plant used traditionally in Canary Islands as a diuretic. In this paper, we report on this pharmacological activity in several extracts of the dry vegetal material collected and the identification and diuretic activity of two withanolides, one of them previously not repo...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.12.014

    authors： Benjumea D,Martín-Herrera D,Abdala S,Gutiérrez-Luis J,Quiñones W,Cardona D,Torres F,Echeverri F

    更新日期：2009-06-22 00:00:00

  • Medicinal plants for gastrointestinal diseases among the Kuki-Chin ethnolinguistic groups across Bangladesh, India, and Myanmar: A comparative and network analysis study.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The Kuki-Chin is a composite ethnolinguistic group made up of many distinct groups and subgroups that are linked by a common history, culture, and population distribution in the Kuki-Chin region, shared geopolitically by Bangladesh, India, and Myanmar. This region is shown to be in a hots...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2019.112415

    authors： Ong HG,Kim YD

    更新日期：2020-04-06 00:00:00

  • Hemostasis and uterine contraction promoting effect of the extract from drugs in the Zi-Yin-Tiao-Jing granule, a traditional Chinese compound preparation.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Zi-Yin-Tiao-Jing granule (ZG) is a traditional Chinese medicine compound preparation for perimenopausal dysfunctional uterine bleeding. It is made from 9 Chinese crude drugs based on a modified traditional Chinese prescription recorded in Fu Qingzhu Nvke as Guben Zhibeng Tang. AIM OF THE...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.09.035

    authors： Tang Q,Yang S,Tong J,Li X,Wu J,Wang S,Zhang J,Chen Y,Xu X

    更新日期：2018-01-30 00:00:00

  • Immunomodulatory activity of the rhizomes of Impatiens pritzellii var. hupehensis on collagen-induced arthritis mice.

    abstract：:Impatiens pritzellii Hook. f. var. hupehensis Hook. f. (Balsaminaceae) has been well-known and widely used in China as an anti-rheumatoid arthritis (anti-RA) herb. In this present study, mice with collagen-induced arthritis (CIA) have been treated with the methanol (MeOH) extract (0.56, 1.12, 1.68 and 2.24 g/kg body w...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.08.026

    authors： Zhou X,Zhao X,Tang L,Zhang Y,Ruan H,Pi H,Qiu J,Wu J

    更新日期：2007-02-12 00:00:00

  • Guarana (Paullinia cupana): toxic behavioral effects in laboratory animals and antioxidants activity in vitro.

    abstract：:The effects on toxic and behavioral levels of guarana (Paullinia cupana) were assessed in rats and mice subsequent to acute and chronic administrations and were compared to those produced by Ginseng (Panax ginseng). Experimental parameters included tests for antioxidant capacity in vitro and measured in vivo, toxicolo...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(97)00141-4

    authors： Mattei R,Dias RF,Espínola EB,Carlini EA,Barros SB

    更新日期：1998-03-01 00:00:00

  • Proteomics annotate therapeutic properties of a traditonal Tibetan medicine - Tsantan Sumtang targeting and regulating multiple perturbed pathways.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Tsantan Sumtang is a traditional Tibetan medicine, which has been traditionally used as medicine for the treatment of cardiopyretic disease which is similar to angina. However, the precise and comprehensive mechanism of it pretreatment remain elusive, so in this study, we used proteomics ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.12.023

    authors： Zhou Y,Li Z,Tang F,Ge R

    更新日期：2016-04-02 00:00:00

  • The natural therapeutic magnesium lithospermate B potently provides neuroprotective effects on cerebral ischemia/reperfusion injury in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Salvia miltiorrhiza, a perennial plant in the genus Salvia and popularly known as "Danshen", is highly valued for its roots in traditional Chinese medicines (TCMs). It has widely used for the treatment of cerebrovascular and cardiovascular diseases in China. Recently, the cerebral protect...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.12.048

    authors： Cao ZQ,Quan W,Hou SX,Guo C,Ma SB,Zhang W,Li X

    更新日期：2015-03-13 00:00:00

  • Laboratory evaluation of the acaricidal properties of extracts from Uraria picta (Leguminosae).

    abstract：:Ethomedical uses of the plant, Uraria picta (Leguminosae), in Nigeria include the control of ectoparasites in man and domestic animals. Total and fractionated extracts of this plant have been assessed for acaricidal activity on Ixodes ricinus. All the extracts were acaricidal to the test organisms. Methanolic extract ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(89)90102-5

    authors： Igboechi AC,Osazuwa EO,Igwe UE

    更新日期：1989-10-01 00:00:00

  • Digitalis: is there a future for this classical ethnopharmacological remedy?

    abstract：:Withering's (1741-1799) greatest merit is not so much that of having discovered the therapeutic value of foxglove in hydropsy, since this indication (among others) was already part of traditional medicine, but actually during a decade of carefully recording clinical observations, he authoritatively settled definite gu...

    journal_title：Journal of ethnopharmacology

    pub_type： 历史文章,杂志文章

    doi：10.1016/0378-8741(91)90109-q

    authors： Marullaz PD

    更新日期：1991-04-01 00:00:00

  • Amelioration of testosterone induced benign prostatic hyperplasia by Prunus species.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Benign prostatic hyperplasia (BPH) is a common urological disorder of men. The ethnomedicinal use of an African plant Prunus africana (Hook.f.) Kalkman (Pygeum) in treating men's problems made it a popular remedy all over the globe for the treatment of BPH and related disorders. However, ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.05.052

    authors： Jena AK,Vasisht K,Sharma N,Kaur R,Dhingra MS,Karan M

    更新日期：2016-08-22 00:00:00

  • Toxicity studies of medicinal plants used in sub-Saharan Africa.

    abstract：:In sub-Saharan Africa, traditional medicine is widely used in rural and urban areas also. This is essentially due to the prohibitive cost of pharmaceutical-based medicine and the low incomes of a major part of the population. In addition, the efficacies of many of these traditional and plant-based medicines are proven...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2015.06.005

    authors： Boukandou Mounanga M,Mewono L,Aboughe Angone S

    更新日期：2015-11-04 00:00:00

  • Application of radioligand receptor binding assays in the search for CNS active principles from Chinese medicinal plants.

    abstract：:Extracts of Schefflera bodinieri and S. delavayi (Araliaceae), Celastrus angulatus and C. orbiculatus (Celastraceae), Clerodendrum mandarinorum and C. bungei (Verbenaceae), Periploca callophylla and P. forrestii (Asclepiadaceae), Alangium platanifolium (Alangiaceae) and Uncaria rhynchophylla (Rubiaceae) were assessed ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(96)01454-7

    authors： Zhu M,Bowery NG,Greengrass PM,Phillipson JD

    更新日期：1996-11-01 00:00:00

  • The taste of heat: How humoral qualities act as a cultural filter for chemosensory properties guiding herbal medicine.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Organoleptic properties, and more specifically chemosensory cues, have been shown to guide therapeutic applications of medicinal plants. Humoral qualities, on the other hand, are widely believed to be an abstract concept, mainly applied post hoc to validate therapy. However, the nexus bet...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.01.027

    authors： Geck MS,Cabras S,Casu L,Reyes García AJ,Leonti M

    更新日期：2017-02-23 00:00:00

  • Potent anti-cervical cancer activity: synergistic effects of Thai medicinal plants in recipe N040 selected from the MANOSROI III database.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCES:One of the prestigious Thai/Lanna folklore wisdoms is the medicinal plant recipes. Thai/Lanna medicinal plant recipe database MANOSROI III has been developed by Prof. Dr. Jiradej Manosroi. It consists of over 200,000 recipes covering all diseases including cancer. AIM OF THIS STUDY:To i...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.06.037

    authors： Kitdamrongtham W,Manosroi A,Akazawa H,Gidado A,Stienrut P,Manosroi W,Lohcharoenkal W,Akihisa T,Manosroi J

    更新日期：2013-08-26 00:00:00

  • Efficacy and short-term safety of topical Dwarf Elder (Sambucus ebulus L.) versus diclofenac for knee osteoarthritis: A randomized, double-blind, active-controlled trial.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Sambucus ebulus L. (S. ebulus) has had long-standing application in Traditional Persian Medicine for joint pain and for a variety of bone and joint disorders. According to traditional use of S. ebulus and its relevant pharmacologic properties, this study was designed to evaluate the effic...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jep.2016.04.035

    authors： Jabbari M,Hashempur MH,Razavi SZ,Shahraki HR,Kamalinejad M,Emtiazy M

    更新日期：2016-07-21 00:00:00

  • Bioactive alkyl phenols and embelin from Oxalis erythrorhiza.

    abstract：:The benzoquinone embelin and four alkyl phenols were isolated from an Argentinean collection of Oxalis erythrorhiza. 3-Heptadecyl-5-methoxy-phenol is reported for the first time. The structures were determined by spectroscopic methods. Embelin presented inhibitory effect on methicillin-resistant Staphylococcus aureus,...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00258-7

    authors： Feresin GE,Tapia A,Sortino M,Zacchino S,de Arias AR,Inchausti A,Yaluff G,Rodriguez J,Theoduloz C,Schmeda-Hirschmann G

    更新日期：2003-10-01 00:00:00

  • Suppressive effect of Petasites japonicus extract on ovalbumin-induced airway inflammation in an asthmatic mouse model.

    abstract：AIM OF THE STUDY:Asthma is a disease marked by airway inflammation. Petasites japonicus (Pj) is known as an herb for treating asthma, oxidant stress and gastric ulcer in traditional Oriental medicine. In this study, the inhibitory effects of Pj extract on asthmatic responses were examined both in vitro and in vivo. MA...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.10.038

    authors： Lee JS,Yang EJ,Yun CY,Kim DH,Kim IS

    更新日期：2011-01-27 00:00:00

  • Antibacterial activities of the methanol extracts, fractions and compounds from Harungana madagascariensis Lam. ex Poir. (Hypericaceae).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Harungana madagascariensis Lam. ex Poir. (Hypericaceae) is used in folk medicine to treat a variety of human ailments, mainly antibacterial, antifungal, antiviral and viral infections. In the present study, the methanol extract from the leaves (HML) and bark (HMB) of this plant as well as...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.06.005

    authors： Tankeo SB,Damen F,Sandjo LP,Celik I,Tane P,Kuete V

    更新日期：2016-08-22 00:00:00

  • Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism.

    abstract：:In India, the decoction of kernels of Eugenia jambolana (EJ) and extracts of Tinospora cordifolia (TC) are used as a household remedy for diabetes. These also form constituents of many herbal formulations for diabetes that are marketed in this country. The anti-hyperglycemic effect of aqueous and alcoholic extracts as...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00319-6

    authors： Grover JK,Vats V,Rathi SS

    更新日期：2000-12-01 00:00:00

  • Effect of Powerdental on caries-inducing properties of Streptococcus mutans and TNF-alpha secretion from HMC-1 cells.

    abstract：:We studied the inhibitory effect of Powerdental on the growth and acid production of Streptococcus mutans as well as secretion of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). The growth of Streptococcus mutans was reduced by the presence of the Powerdental (1 mg/ml) and NaCl (1 mg/ml) significant...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.03.023

    authors： You YO,Shin HY,Yu HH,Yoo SJ,Kim SH,Kim YK,Hong SH,Shin TY,Kim HM

    更新日期：2004-06-01 00:00:00

  • Anti-tumor effects and mechanisms of Astragalus membranaceus (AM) and its specific immunopotentiation: Status and prospect.

    abstract：:With cancer deaths increasing, the initiation, pathophysiology and curative management of cancer is receiving increasing attention. Traditional therapies such as surgery and chemoradiotherapy are often accompanied by suppression of host immunity, which increase the risk of metastasis. Astragalus membranceus (AM) is co...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2020.112797

    authors： Li S,Sun Y,Huang J,Wang B,Gong Y,Fang Y,Liu Y,Wang S,Guo Y,Wang H,Xu Z,Guo Y

    更新日期：2020-08-10 00:00:00