Effect of Powerdental on caries-inducing properties of Streptococcus mutans and TNF-alpha secretion from HMC-1 cells.

Abstract:

:We studied the inhibitory effect of Powerdental on the growth and acid production of Streptococcus mutans as well as secretion of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). The growth of Streptococcus mutans was reduced by the presence of the Powerdental (1 mg/ml) and NaCl (1 mg/ml) significantly, and the positive control group (1% NaF) also exhibited a significant antibacterial activity. The decrease of pH was significantly inhibited in the presence of Powerdental (1 mg/ml) compared to the control group. The decrease in pH was also inhibited in the presence of positive control (1% NaF), but the bamboo salt alone did not show inhibitory activity. We also found that Powerdental (0.01 mg/ml) inhibited significantly the secretion of TNF-alpha with 46.5+/-0.2% from human mast cells. Our results suggest that Powerdental contributes to the prevention or treatment of periodontitis and other oral diseases or inflammatory diseases.

journal_name

J Ethnopharmacol

authors

You YO,Shin HY,Yu HH,Yoo SJ,Kim SH,Kim YK,Hong SH,Shin TY,Kim HM

doi

10.1016/j.jep.2004.03.023

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

331-5

issue

2-3

eissn

0378-8741

issn

1872-7573

pii

S0378874104001321

journal_volume

92

pub_type

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