Efficacy and safety of indigo naturalis ointment in Treating Atopic Dermatitis: A randomized clinical trial.

Abstract:

ETHNOPHARMACOLOGICAL RELEVANCE:Indigo naturalis, a herbal medicine with a history of use dating back to ancient times, may be a good alternative topical treatment for atopic dermatitis (AD). AIM OF THE STUDY:To provide empirical evidence of the efficacy and safety of Indigo naturalis ointment in treating AD. MATERIALS AND METHODS:In this randomized double-blind clinical trial, participants aged 6 to 65 years with AD affecting less than 40% of their body surface area (BSA) and an Investigator's Global Assessment (IGA) score of 2 to 4 were randomized (2:1) to receive either Lindioil ointment or a vehicle ointment twice daily for 6 weeks. The primary endpoint was the percentage change in the Eczema Area Severity Index (EASI) from baseline to week 6. Secondary endpoints were as follows: EASI improvement ≥50%, 75%, and 90%; IGA score; BSA affected by AD; pruritus severity; and Dermatology Life Quality Index. The safety assessment included adverse events (AEs), laboratory tests, and physical examinations. RESULTS:The Lindioil group (32 participants) and vehicle group (16 participants) achieved mean percentage EASI reductions of 49.9% ± 36.5% (95% CI 36.8%-63.1%) and 19.6% ± 52.2% (95% CI -8.2%-47.4%), respectively (P = 0.0235). The Lindioil group also showed greater improvement in every secondary assessment category. No significant AEs occurred. CONCLUSION:Indigo naturalis ointment is effective for treating mild to severe AD topically, and appears to be safe. This is the first clinical trial to provide evidence supporting topical indigo-based AD treatment. ClinicalTrials.gov identifier: NCT02669888.

journal_name

J Ethnopharmacol

authors

Lin YK,Chang SH,Yang CY,See LC,Lee BH,Shih IH

doi

10.1016/j.jep.2019.112477

subject

Has Abstract

pub_date

2020-03-25 00:00:00

pages

112477

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(19)32789-8

journal_volume

250

pub_type

杂志文章,随机对照试验
  • Metabolomics coupled with SystemsDock reveal the protective effect and the potential active components of Naozhenning granule against traumatic brain injury.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Naozhenning granule (NZN), a widely traditional Chinese medicine (TCM) prescription with a long history of clinical, which is mainly used in the treatment of concussion, cerebral post-traumatic syndrome, consists of Di Huang (Radix of Rehmannia glutinosa (Gaertn.) DC.), Dang Gui (Radix of...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.112247

    authors: Cao J,Duan Y,Liu Y,Liu H,Wei C,Wang J,Qin X,Wang X,Li Z

    更新日期:2020-01-10 00:00:00

  • Acute toxicity, antinociceptive activity and indole alkaloids of aqueous extract from bark of Aspidosperma cuspa (Kunth) Blake.

    abstract:UNLABELLED:ETNOPHARMACOLOGICAL RELEVANCE: Aspidosperma cuspa (Kunth) Blake (Apocynaceae) is popularly known as "amargosa" or "cuspa", and its bark is used in folk medicine primarily for pain. AIM OF THE STUDY:In the present study the acute toxicity, antinociceptive effect and alkaloids of the aqueous decoction extract...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2012.07.021

    authors: Pérez NM,Torrico FB,Morales A

    更新日期:2012-09-28 00:00:00

  • Preventive effect of Abelmoschus manihot (L.) Medik. on bone loss in the ovariectomised rats.

    abstract::Because the biggest culprit in pathogenesis of osteoporosis is oestrogen deficiency, hormone replacement therapy remained the mainstay for prevention. However most of postmenopausal women are more inclined to use natural alternative. We thus investigated the ability of Abelmoschus manihot, a herbal medicine to prevent...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2005.01.047

    authors: Puel C,Mathey J,Kati-Coulibaly S,Davicco MJ,Lebecque P,Chanteranne B,Horcajada MN,Coxam V

    更新日期:2005-05-13 00:00:00

  • A double-blind randomized placebo-controlled clinical study to evaluate the efficacy and safety of a polyherbal formulation in geriatric age group: a phase IV clinical report.

    abstract:AIM OF THE STUDY:We sought to determine the efficacy as antioxidant and safety profile of the polyherbal formulation in geriatric patients of eastern India. MATERIALS AND METHODS:The study was double-blind, randomized including placebo controlled and was approved by the ethical committee of SSKM hospital. Geriatric pa...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jep.2010.12.044

    authors: Banerjee P,Maity S,Das T,Mazumder S

    更新日期:2011-03-24 00:00:00

  • Medicinal plants in Baskoure, Kourittenga Province, Burkina Faso: an ethnobotanical study.

    abstract:AIM OF THE STUDY:The majority of people living in Kourittenga Province, Burkina Faso, are highly dependent on medicinal plants for their daily health care. Knowledge on the use of medicinal plants by traditional healers is being seriously threatened, due to the fact that it is commonly transferred from one generation t...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2010.10.010

    authors: Nadembega P,Boussim JI,Nikiema JB,Poli F,Antognoni F

    更新日期:2011-01-27 00:00:00

  • Antiquity of medicinal plant usage in two Macro-Mayan ethnic groups (México).

    abstract::In the biological sciences the use of medicinal plants in indigenous cultures is commonly seen as being based on a long tradition ('traditional medicine'). However, under normal circumstances, ethnobotanical studies cannot provide evidence on the antiquity of specific uses for medicinal plants since oral traditions ha...

    journal_title:Journal of ethnopharmacology

    pub_type: 历史文章,杂志文章

    doi:10.1016/s0378-8741(03)00188-0

    authors: Leonti M,Sticher O,Heinrich M

    更新日期:2003-10-01 00:00:00

  • A survey on medicinal materials used in traditional systems of medicine in Sri Lanka.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Sri Lanka has rich traditional systems of medicine, which cater to 60-70% of the rural population׳s primary health care needs. However, development of existing systems has been hindered by the unavailability of up-to-date information on medicinal materials and other related issues. For st...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2014.06.016

    authors: Kankanamalage TN,Dharmadasa RM,Abeysinghe DC,Wijesekara RG

    更新日期:2014-08-08 00:00:00

  • Some phytochemical aspects of medicinal plant research.

    abstract::Various aspects of medicinal plant research, i.e. collection of data, screening for biological activity and isolation and identification of active compounds are briefly discussed with special reference to phytochemical aspects. Based upon this some topics for further methodological research are presented. A strategy f...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/0378-8741(89)90044-5

    authors: Verpoorte R

    更新日期:1989-02-01 00:00:00

  • Anti-inflammatory effects of Sarcopoterium spinosum extract.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Sarcopoterium spinosum is a Mediterranean plant, widely used by the Beduin traditional medicine. While its major use is for the treatment of diabetes, there are also documentations for its use as anti-inflammatory agent. This therapeutic potential of Sarcopoterium spinosum was not validat...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.112391

    authors: Rozenberg K,Wollman A,Ben-Shachar M,Argaev-Frenkel L,Rosenzweig T

    更新日期:2020-03-01 00:00:00

  • Knowledge and use of medicinal plants by people around Debre Libanos monastery in Ethiopia.

    abstract::The study was conducted around Debre Libanos monastery from October 2005 to June 2006. A total of 250 villagers, 13 monks and 3 nuns were interviewed using semistructured questionnaire on the knowledge and use of medicinal plants. The informant consensus factor (ICF) and the fidelity level (FL) of the species were det...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2006.11.019

    authors: Teklehaymanot T,Giday M,Medhin G,Mekonnen Y

    更新日期:2007-05-04 00:00:00

  • Evaluation of some plants used in Turkish folk medicine against parasitic infections for their in vivo anthelmintic activity.

    abstract::Ethanolic and aqueous extracts obtained from nine plant species from seven families selected depending on their use in Turkish folk medicine, including Citrillus lanatus (Thunb.) Matsum. (seed), Jasminum fruticans L. (branches), Juniperus drupacea Labill. (fruits), Juniperus nana L. (fruit and leaves), Juniperus oxcyc...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2006.05.003

    authors: Kozan E,Küpeli E,Yesilada E

    更新日期:2006-11-24 00:00:00

  • Folk medical uses of plant foods in southern Appalachia, United States.

    abstract::An analysis of information obtained from interviews with 660 older native inhabitants of the southern Appalachian region in the United States indicates that plant foods, especially cultivars and materials processed from them, and some wildcrafted plant foods as well, constituted the bulk of the folk materia medica in ...

    journal_title:Journal of ethnopharmacology

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.jep.2006.04.008

    authors: Cavender A

    更新日期:2006-11-03 00:00:00

  • Immunostimulant effects of Capparis zeylanica Linn. leaves.

    abstract::The present study was undertaken to explore the immunomodulatory activity of ethanolic and water extracts of Capparis zeylanica Linn. (family: Capparidaceae) leaves on neutrophil adhesion test, humoral response to sheep red blood cells, delayed-type hypersensitivity, phagocytic activity and cyclophosphamide-induced my...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2006.03.041

    authors: Ghule BV,Murugananthan G,Nakhat PD,Yeole PG

    更新日期:2006-11-24 00:00:00

  • Larvicidal activity of extracts from Quercus lusitania var. infectoria galls (Oliv.).

    abstract::The present study indicates the efficacy of extracts and fractions of Quercus lusitania var. infectoria galls (Oliv.) as larvicidal agents and their possible use in biological control of Culex pipiens, the urban nuisance mosquito. Extracts and fractions were tested against second and fourth instar larvae. The LC(50) v...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(01)00390-7

    authors: Redwane A,Lazrek HB,Bouallam S,Markouk M,Amarouch H,Jana M

    更新日期:2002-02-01 00:00:00

  • Effects of Eugenia umbelliflora O. Berg (Myrtaceae)-leaf extract on inflammation and hypersensitivity.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The leaves of Eugenia species are widely used in popular medicine to treat several diseases, such as arthritis, rheumatism and diabetes. Eugenia umbelliflora O. Berg is popularly known in Brazil as "baguaçu", name also conferred to Eugenia jambolana probably due to their apparent similari...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.112133

    authors: Goldoni FC,Barretta C,Nunes R,Broering MF,De Faveri R,Molleri HT,Corrêa TP,Farias IV,Amorin CK,Pastor MVD,Meyre-Silva C,Bresolin TMB,de Freitas RA,Quintão NLM,Santin JR

    更新日期:2019-11-15 00:00:00

  • Influence of aqueous extract from Neurada procumbens L. on blood pressure of rats.

    abstract::Neurada procumbens is a desert plant in the Arabian Peninsula. It has been considered edible by Bedouin and has been used traditionally as a medicinal herb. During a screening test of Arabian plants, the aqueous extract of Neurada procumbens increased the blood pressure of anaesthetized normotensive rats when it was a...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2003.09.045

    authors: Chen HB,Islam MW,Radhakrishnan R,Wahab SA,Naji MA

    更新日期:2004-02-01 00:00:00

  • The anti-tumor effect and bioactive phytochemicals of Hedyotis diffusa willd on ovarian cancer cells.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Hedyotis diffusa willd (HDW) is a widely used medicinal herb in China. It processed various medicinal properties including antioxidative, anti-inflamatory and anti-cancer effects. This study aimed to investigate the anti-tumor effects of HDW on ovarian cancer cells and the underlying mech...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2016.07.027

    authors: Zhang L,Zhang J,Qi B,Jiang G,Liu J,Zhang P,Ma Y,Li W

    更新日期:2016-11-04 00:00:00

  • In vitro antibacterial activities of three plants used in traditional medicine in Sierra Leone.

    abstract::The antibacterial activities of the methanol and hot and cold aqueous extracts of the leaves of Aspilia africana, Ficus exasperata and Mareya micrantha were bioassayed against three Gram-negative and three Gram-positive bacterial species: Aerobacter aerogenes, Agrobacterium tumefaciens, Bacillus subtilis, Clostridium ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(90)90083-6

    authors: Macfoy CA,Cline EI

    更新日期:1990-03-01 00:00:00

  • Toxicological studies of the aqueous extract from Achyrocline satureioides (Lam.) DC (Marcela).

    abstract::Achyrocline satureioides (Lam.) DC (Marcela) is known to possess a broad spectrum of pharmacological, medicinal and therapeutic properties. Previous studies have demonstrated various protective abilities of the marcela extracts against various pathological conditions. However, no extensive safety studies have been con...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2004.08.013

    authors: Rivera F,Gervaz E,Sere C,Dajas F

    更新日期:2004-12-01 00:00:00

  • Protective effect of GCSB-5, an herbal preparation, against peripheral nerve injury in rats.

    abstract:AIM OF THE STUDY:GCSB-5 (traditional name: Chungpa-Juhn), an herbal medicine composed of 6 crude herbs (Saposhnikovia divaricata Schiskin, Achyranthis bidentata Blume, Acanthopanax sessiliflorum Seem, Cibotium baromets J. Smith, Glycine max Meriill, and Eucommia ulmoides Oliver), has been widely used in Asia for treatm...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.04.037

    authors: Kim TH,Yoon SJ,Lee WC,Kim JK,Shin J,Lee S,Lee SM

    更新日期:2011-06-22 00:00:00

  • Berberine improves neurogenic contractile response of bladder detrusor muscle in streptozotocin-induced diabetic rats.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Coptidis Rhizoma has been used to treat diabetes mellitus for more than 1400 years in China. Berberine, one of the main alkaloids of Coptidis Rhizoma, is a principal antidiabetic component of Coptidis Rhizoma. To investigate the effects of berberine on impaired neurogenic contractility of...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2013.10.039

    authors: Ren LM,Zhuo YJ,Hao ZS,He HM,Lu HG,Zhao D

    更新日期:2013-12-12 00:00:00

  • Hepatoprotective and toxicological assessment of an ethnomedicinal plant Euphorbia fusiformis Buch.-Ham.ex D.Don.

    abstract:AIM OF THE STUDY:The tubers of Euphorbia fusiformis Buch.-Ham.ex D.Don (Euphorbiaceae) are traditionally used in India by the Malayali tribes of Chitteri hills, Eastern Ghats, Tamil Nadu to treat liver disorders. The objective of the present study was to assess the hepatoprotective potential and biosafety of Euphorbia ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2009.10.012

    authors: Anusuya N,Raju K,Manian S

    更新日期:2010-02-03 00:00:00

  • Diuretic, natriuretic and hypotensive effects produced by Allium sativum (garlic) in anaesthetized dogs.

    abstract::Gastric administration of encapsuled garlic powder to anaesthetized dogs induced dose-dependent (2.5 to 15 mg/kg) natriuretic and diuretic responses which reached maximum 30-40 min after garlic administration and decreased to basal levels after 100-150 min. A simultaneous decrease in arterial blood pressure was observ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(91)90018-9

    authors: Pantoja CV,Chiang LC,Norris BC,Concha JB

    更新日期:1991-03-01 00:00:00

  • Pharmacological and toxicological studies of Drimys angustifolia Miers. (Winteraceae).

    abstract::Drimys angustifolia Miers. (Winteraceae) is a Brazilian medicinal plant used as analgesic, antiulcer and anti-inflammatory without studies to assure its efficacy and safety Leaf and stem bark extracts were evaluated to determine the antiulcer, analgesic, antiinflammatory and antioxidant activities. Preliminary toxic e...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2006.12.025

    authors: Witaicenis A,Roldão EF,Seito LN,Rocha NP,Di Stasi LC

    更新日期:2007-05-22 00:00:00

  • In vitro anti-proliferative and antioxidant studies on Devil's Club Oplopanax horridus.

    abstract::Devil's Club, Oplopanax horridus (OH), is a widely used folk medicine in Alaska and British Columbia for treating a variety of ailments including arthritis, fever and diabetes. HPLC profiling shows that numerous compounds are present in the 70% ethanolic extract of OH dry root bark powder. OH extract inhibited K562, H...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2006.05.018

    authors: Tai J,Cheung S,Cheah S,Chan E,Hasman D

    更新日期:2006-11-24 00:00:00

  • Effect of glycans of Saccharum officinarum on carbohydrate and lipid metabolism of rats.

    abstract::A polysaccharide fraction of Saccharum officinarum was tested for its effects on carbohydrate and lipid metabolism in normal rats and those fed a high sugar diet. Feeding with the high sugar diet induced an elevation of serum glucose and significant accumulation of lipid peroxides in the serum and liver. The accumulat...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(85)90092-3

    authors: Hikino H,Takahashi M,Konno C,Ishimori A,Kawamura T,Namiki T

    更新日期:1985-11-01 00:00:00

  • Isolation of seselin from Clausena anisata (Rutaceae) leaves and its effects on the feeding and development of Lucilia cuprina larvae may explain its use in ethnoveterinary medicine.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The leaves of Clausena anisata are used traditionally to expel maggots from wounds of animals in Zimbabwe. We have previously proved in the laboratory that the plant certainly affects the behaviour and growth of blowfly larvae. The objective of this study was to isolate and identify the a...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2013.09.037

    authors: Mukandiwa L,Ahmed A,Eloff JN,Naidoo V

    更新日期:2013-12-12 00:00:00

  • The gastroprotective activity of the ethanol extract of Ageratum conyzoides.

    abstract::The ethanol extract of Ageratum conyzoides was evaluated for gastroprotection in rats using the Ibuprofen, ethanol and cold restraint stress ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and ulcer index. Oral administration of the ethanol extract at dose levels of 500 and 750 mg...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(03)00050-3

    authors: Shirwaikar A,Bhilegaonkar PM,Malini S,Kumar JS

    更新日期:2003-05-01 00:00:00

  • An assessment of the Chinese medicinal Dendrobium industry: Supply, demand and sustainability.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:A high proportion of species native to China from the genus Dendrobium (Orchidaceae) have been used as folk medicine for more than 2300 years. The fresh or dried stem of many Dendrobium species are regarded as "superior grade" tonic in Traditional Chinese Medicine (TCM), for their traditi...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jep.2018.09.001

    authors: Cheng J,Dang PP,Zhao Z,Yuan LC,Zhou ZH,Wolf D,Luo YB

    更新日期:2019-01-30 00:00:00

  • Isolation and characterization of antimicrobial compounds from Terminalia phanerophlebia Engl. & Diels leaf extracts.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The emergence of drug resistant-tuberculosis and other pathogenic diseases over the past decades, constitutes a serious threat to human health worldwide. According to a 2012 report by the World Health Organization (WHO), South Africa, China, India and Russia are the countries with the hig...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2014.09.003

    authors: Madikizela B,Aderogba MA,Finnie JF,Van Staden J

    更新日期:2014-10-28 00:00:00