Abstract:
:The purpose of this study is to assess the protective effects exerted by Schisandra fructus (SF) on hyaluronidase (HAase) and the recombinant human interleukin-1beta (IL-1beta) induced matrix degradation in human articular cartilage and chondrocytes. The effect of SF on the matrix gene expression of immortalized chondrocyte cell line C-28/I2 treated with HAase was investigated using a reverse transcription polymerase chain reaction (RT-PCR). In addition, the effects of SFEA on HAase and IL-1beta induced matrix degradation in human articular cartilage were assessed using a staining method, and the quantity of glycosaminoglycan (GAG) degraded was calculated from the cultured media. In HAase treatment group, the released GAGs content increased significantly to 15.8+/-0.7 microg, compared with control levels (5.0+/-0.2 microg), whereas co-treatment with SFEA (100 microg/ml) reduced the GAG release to 10.8+/-0.7 microg (P<0.05). Also, in the group treated only with IL-1beta (11.9+/-0.3 microg), the amount of released GAG increased significantly compared to the control (7.9+/-0.1 microg) and the SFEA-treated group (7.8+/-0.4 microg). SFEA at 100 microg/ml inhibited PG degradation (9.0+/-0.5 microg, P<0.05). However, no concentration-dependent increases in inhibitory activity were observed. Therefore, since SFEA treatment resulted in no pathological impact on either the chondrocytes or cartilage, we suggest that SF can be safely used as an effective material for the prevention of proteoglycan (PG) degradation.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Choi SI,Park SR,Heo TRdoi
10.1016/j.jep.2005.12.018keywords:
subject
Has Abstractpub_date
2006-06-30 00:00:00pages
279-84issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(05)00837-8journal_volume
106pub_type
杂志文章abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The role of Azadirachta indica (neem) against Chagas disease and its antibiotic and antidiabetic action have been demonstrated in non-pregnant animals. However, the effects of neem on lipid metabolism and oxidative stress during pregnancy remain to be investigated. The objective of this s...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2012.07.023
更新日期:2012-10-11 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Scorzonera species are mainly used against arteriosclerosis, kidney diseases, hypertension, diabetes mellitus and rheumatism, as well as for pain relief and wound healing in Turkish folk medicine. In the current study, aerial parts and roots of Scorzonera cinerea, Scorzonera incisa, Scorz...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2011.07.029
更新日期:2011-09-02 00:00:00
abstract:ETHNO PHARMACOLOGICAL RELEVANCE:Sida cordifolia is used commonly in traditional systems of medicine (TSM) and as folk remedies for treating the wounds (both external and internal), infected area, rheumatic disorders, muscular weakness, tuberculosis, heart problems, bronchitis, neurological problems etc. Therefore, in o...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2018.07.003
更新日期:2019-05-10 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Licorice (Glycyrrhizae radix), the root of Glycyrrhiza uralensis Fisch. (Leguminosae), is mainly used to moderate the characteristics of toxic herbs in Traditional Chinese Medicine, which could be partly interpreted as detoxification. However, the underlying mechanism is still not fully e...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2014.12.043
更新日期:2015-03-13 00:00:00
abstract::We have studied extracts from three species rich in lanostane triterpenes for their activity against different in vivo models of inflammation induced by TPA, EPP and PLA(2). The inhibitory effect against PLA(2) in vitro was also studied. When the Poria cocos extract was tested against PLA(2)-induced mouse paw edema, i...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(00)00276-2
更新日期:2000-11-01 00:00:00
abstract::Humulus lupulus (hops) is traditionally used as a tranquilizing herbal remedy. Here, we investigated the in vivo and in vitro effect of hop beta-acids on central nervous system function. Oral administration of beta-acids (5-10mg/kg) in rats produced an increased exploratory activity in the open field, a reduction in t...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2006.07.008
更新日期:2007-01-03 00:00:00
abstract::Poisonous plants and animals are widespread in nature and have been used for a great variety of purposes. Brief discussions of a number of examples: aconite, ergot, Euphorbiaceae/Thymelaeaceae, curare, cardiac glycosides, triterpenoid saponins and animal toxins, make the point that, in addition to allowing their use a...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/0378-8741(91)90105-m
更新日期:1991-04-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Lilhocarpus polystachys Rehd. (Sweet Tea, ST) is a folk herbal medicine that has been traditionally used as a natural remedy for hypertension in China, whose mechanism remains unveiled. Flavonoid fraction is considered as the major active components in ST. This study aimed to provide expe...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2012.06.016
更新日期:2012-09-28 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The aim of the present study was to document the medicinal plants by the traditional medical practitioners from Kalrayan hills of Villupuram district in Tamil Nadu, India. Quantitatively analyses of the data were made to acquire some useful leads for further studies. MATERIALS AND METHOD...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2014.09.014
更新日期:2014-11-18 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:In African traditional medicine, Ageratum conyzoides has been used as purgative, febrifuge, anti-ulcer and wound dressing. To date there is no safety information about long term use of Ageratum conyzoides which contains pyrrolizidine alkaloids, a class of hepatotoxic and carcinogenic phyt...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2014.07.005
更新日期:2014-09-11 00:00:00
abstract::Powdered Solanum lycocarpum fruit is commonly used to treat diabetes, but apparently no studies have been conducted to evaluate potential adverse side effects. In the present paper the toxic effect of S. lycocarpum was evaluated in adult male Wistar rats and Swiss mice. The administration of an aqueous extract prepare...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(00)00250-6
更新日期:2000-11-01 00:00:00
abstract:AIM:CGX, a modified traditional Chinese herbal drug whose name means "liver cleaning," is used to treat various liver disorders. This study investigated the protective effects of CGX and its mechanisms. MATERIAL AND METHODS:After pretreating ICR mice twice daily with CGX (po, 50 or 100mg/kg) or distilled water for thr...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2008.07.042
更新日期:2008-10-30 00:00:00
abstract::The effect of ethanol extract of Carpolobia lutea leaves on experimentally induced diarrhoea and ulcers was studied in rodents. The extract (245-735 mg/kg) inhibited small intestinal transit time (15.10-45.03%), castor oil-induced diarrhoea (25.69-43.54%) and fluid accumulation (7.53-34.15%), respectively, as well as ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2007.01.019
更新日期:2007-05-22 00:00:00
abstract::The effects of extracts from various oriental medicinal herbs on mast cell-mediated allergic reaction were investigated. Among them, Chrysanthemi sibirici herba ethanol extract exerted the potent inhibitory activity on antigen-induced degranulation in RBL-2H3 mast cells. Chrysanthemi sibirici herba dose-dependently in...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2004.08.023
更新日期:2004-12-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The herbal composition Gyeongshingangjeehwan 18 (GGEx18), composed of Rheum palmatum L. (Polygonaceae), Laminaria japonica Aresch (Laminariaceae), and Ephedra sinica Stapf (Ephedraceae), is used as an antiobesity drug in Korean clinics. The constituents of GGEx18 have traditionally been r...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2018.06.034
更新日期:2018-10-28 00:00:00
abstract::Several plants are traditionally used to treat mental diseases in South Africa. Forty-six ethanol extracts from 35 species, both indigenous and exotic that are traditionally used predominantly as sedatives or to treat various CNS-related ailments were tested in the GABAA-benzodiazepine receptor-binding assay. In this ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2005.04.004
更新日期:2005-08-22 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Infertility affects many women in Cameroon, with a rate of about 25%. This study aimed at collecting and documenting information on herbal remedies traditionally used for the treatment of women infertility in Baham subdivision (Western Region of Cameroon). MATERIALS AND METHODS:Fieldwork...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2011.04.036
更新日期:2011-06-14 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Modified Si-Miao-San (mSMS) is a prescription modified from Si-Miao-San which is an ancient Chinese prescription used to treat various ailments. AIM OF THE STUDY:Modified Si-Miao-San (mSMS) has been used for the treatment of infectious and inflammatory disorders in the clinic. This study...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2010.02.002
更新日期:2010-05-04 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The root extract of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) is traditionally used in the management of pain and fever. However, little scientific data exists in literature to support its use. AIM OF STUDY:The present study evaluated the anti-nociceptive and antipyretic ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2017.02.007
更新日期:2017-03-06 00:00:00
abstract::The chemical composition, pharmacological activity and traditional uses of 52 species attributed to the genus Lippia (Verbenaceae) as used in the South and Central America, and Tropical Africa, were revised and compared. A survey of the available literature shows that these species are used mostly for the treatment of...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/s0378-8741(01)00234-3
更新日期:2001-08-01 00:00:00
abstract::We studied the inhibitory effect of Powerdental on the growth and acid production of Streptococcus mutans as well as secretion of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). The growth of Streptococcus mutans was reduced by the presence of the Powerdental (1 mg/ml) and NaCl (1 mg/ml) significant...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2004.03.023
更新日期:2004-06-01 00:00:00
abstract::More than 100 antileukodermic recipes, involving about 80 plant species used in Italy through the centuries, were collected from Renaissance texts, folk medicine and contemporary herbal usage. The possible efficacy of the recorded plants in stimulating physiological skin pigmentation is discussed in the light of prese...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/0378-8741(89)90091-3
更新日期:1989-11-01 00:00:00
abstract::The plant, Typhonium flagelliforme (Araceae), commonly known as the "rodent tuber" in Malaysia, is often used as an essential ingredient of herbal remedies for alternative cancer therapies. The hexane extract of this plant was evaluated for cytotoxic activity against in vitro culture on P388 murine leukaemia cells and...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(01)00274-4
更新日期:2001-09-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Precise target distribution is a key issue for further appreciate applications of fangjis (formulas) with similar efficacy and herbal constituents to maximize efficacy and minimize toxicity. AIM OF THE STUDY:To develop an algorithm for investigating the differential target distributions ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2021.113822
更新日期:2021-01-15 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Amburana cearensis (Allemao) A.C.Sm. is a medicinal plant of the Brazilian Caatinga reported to present antioxidant and anti-inflammatory activity. This study aimed to evaluate the neuroprotective effect of the extracts obtained from the seeds of A. cearensis in primary cultures of cerebe...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2017.07.017
更新日期:2017-09-14 00:00:00
abstract:AIMS OF THE STUDY:This study was to investigate the gastrokinetic activity of Morinda citrifolia aqueous fruit extract (AFE) in human subjects by examining the GI absorption of ranitidine, a putative indicator of GI motility and to elucidate its possible gastrokinetic mechanism of action in rats. MATERIALS AND METHODS...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jep.2012.04.044
更新日期:2012-07-13 00:00:00
abstract::The effects on toxic and behavioral levels of guarana (Paullinia cupana) were assessed in rats and mice subsequent to acute and chronic administrations and were compared to those produced by Ginseng (Panax ginseng). Experimental parameters included tests for antioxidant capacity in vitro and measured in vivo, toxicolo...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(97)00141-4
更新日期:1998-03-01 00:00:00
abstract::Hemidesmus indicus has been shown to possess significant activity against immunotoxicity and other pharmacological and physiological disorders. In this communication, we have shown the modulating effect of H. indicus on cumene hydroperoxide-mediated cutaneous oxidative stress and tumor promotion response in murine ski...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(02)00360-4
更新日期:2003-03-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Chrysanthemum morifolium Ramat (Asteraceae) has (CM) long been used in Korean and Chinese traditional herbal medicines with numerous therapeutic applications. AIM OF THE STUDY:To evaluate the neuroprotective activities of Chrysanthemum morifolium (CM) extract against 1-methyl-4-phenylpri...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2009.09.017
更新日期:2009-12-10 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Eupatorium perfoliatum L. has been used traditionally for the treatment of fever, malaria and inflammation-associated diseases. Nowadays it is mostly used as immune activating remedy. The following study was performed to evaluate extracts with different polarity and defined lead-compounds...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2011.05.040
更新日期:2011-09-01 00:00:00