Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE:The herbal composition Gyeongshingangjeehwan 18 (GGEx18), composed of Rheum palmatum L. (Polygonaceae), Laminaria japonica Aresch (Laminariaceae), and Ephedra sinica Stapf (Ephedraceae), is used as an antiobesity drug in Korean clinics. The constituents of GGEx18 have traditionally been reported to inhibit obesity and related metabolic diseases such as insulin resistance and dyslipidemia. OBJECTIVE:This study investigated the effects of GGEx18 on nonalcoholic fatty liver disease (NAFLD) in mice fed a high-fat diet (HFD) and the underlying cellular and molecular mechanisms involved. METHODS:C57BL/6 J mice were fed either a low-fat diet (LFD), an HFD, or an HFD supplemented with GGEx18 (125, 250, or 500 mg/kg of body weight/day). After 13 weeks, blood analyses, histology, immunohistochemistry, and real-time PCR were performed to assess NAFLD development in these mice. RESULTS:Mice fed an HFD had increases in body weight, epididymal adipose tissue mass, adipocyte size, and adipose expression of inflammation-related genes compared with those fed an LFD. These increases were ameliorated in mice treated with 500 mg/kg/day GGEx18 without affecting food consumption profiles. GGEx18 not only decreased serum levels of triglycerides, free fatty acids, and alanine aminotransferase, but also decreased hepatic lipid accumulation, numbers of mast cells and α-smooth muscle actin-positive cells, and collagen levels induced by an HFD. Consistent with the histological data, the hepatic expression of lipogenesis-, inflammation-, and fibrosis-related genes was lower, while hepatic fatty acid β-oxidation-related gene expression was higher, in mice receiving GGEx18 compared to mice fed only the HFD. DISCUSSION AND CONCLUSION:These results indicate that GGEx18 attenuates visceral obesity and NAFLD, in part by altering the expression of genes involved in hepatic steatosis and fibroinflammation in HFD-induced obese mice. These findings suggest that GGEx18 may be effective for preventing and treating NAFLD associated with visceral obesity.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Lim J,Lee H,Ahn J,Kim J,Jang J,Park Y,Jeong B,Yang H,Shin SS,Yoon Mdoi
10.1016/j.jep.2018.06.034subject
Has Abstractpub_date
2018-10-28 00:00:00pages
31-41eissn
0378-8741issn
1872-7573pii
S0378-8741(18)30388-Xjournal_volume
225pub_type
杂志文章abstract:AIM OF THE STUDY:Salvianolic-acid B (SA-B) is an effective component of Radix Salviae miltiorrhizae for anti-hepatic fibrotic herbs. MAPK signaling pathway has been implicated in hepatic stellate cells (HSC) stimulated by TGF-(1. We have investigated the effect of SA-B on MAPK pathway in rat HSC. MATERIALS AND METHODS...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2010.05.026
更新日期:2010-11-11 00:00:00
abstract::Oral administration of a CH(2)Cl(2)-MeOH (1:1) extract of Scaphyglottis livida produced dose-dependent antinociceptive and anti-inflammatory effects when tested in mice and rats using the hot-plate (150-600 mg/kg) and carrageenan-induced inflammation (150-600 mg/kg) models, respectively. Morphine (1.5-6 mg/kg, p.o.) a...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2007.07.021
更新日期:2007-11-01 00:00:00
abstract::The plant, Typhonium flagelliforme (Araceae), commonly known as the "rodent tuber" in Malaysia, is often used as an essential ingredient of herbal remedies for alternative cancer therapies. The hexane extract of this plant was evaluated for cytotoxic activity against in vitro culture on P388 murine leukaemia cells and...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(01)00274-4
更新日期:2001-09-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Melissa officinalis L. is a medicinal plant that has long been used in different ethno-medical systems especially in the European Traditional Medicine and the Iranian Traditional Medicine for the treatment of several diseases. It is also widely used as a vegetable and to add flavor to dis...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2016.05.010
更新日期:2016-07-21 00:00:00
abstract::Preliminary antimicrobial screening against Candida albicans and selected Gram-positive and Gram-negative bacteria of methanol extracts prepared from eight Mexican medicinal plants, noted for their antiseptic properties, was conducted. The significant activity exhibited for extracts of Ratibida latipalearis, Teloxys g...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/0378-8741(92)90025-m
更新日期:1992-01-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The rich flora of Guinea-Bissau, and the widespread use of medicinal plants for the treatment of various diseases, constitutes an important local healthcare resource with significant potential for research and development of phytomedicines. The goal of this study is to prepare a comprehen...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2016.02.032
更新日期:2016-05-13 00:00:00
abstract::We have studied extracts from three species rich in lanostane triterpenes for their activity against different in vivo models of inflammation induced by TPA, EPP and PLA(2). The inhibitory effect against PLA(2) in vitro was also studied. When the Poria cocos extract was tested against PLA(2)-induced mouse paw edema, i...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(00)00276-2
更新日期:2000-11-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis are popular plants used in traditional Chinese medicine to treat diabetes. AIM OF THE STUDY:The aim of the study is to investigate the therapeutic effect of the active components of Euonymus alatus, Radix tricho...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2017.03.015
更新日期:2017-04-18 00:00:00
abstract::The investigation into the effects of Ginkgo biloba extracts on tinnitus has suffered from a dearth of effective animal models as well as systematic clinical trials employing double-blind and placebo-controlled designs. Some clinical trials have yielded positive results, however, these studies are few and have been li...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2005.05.032
更新日期:2005-08-22 00:00:00
abstract::The neuropharmacological activities of the aqueous extract of Diospyros mespiliformis stem bark were screened in mice. The extracts effect on pentobarbital-induced sleeping time, pentylenetetrazole induced seizure, spontaneous motor activity (SMA), exploratory behaviour, and rota-rod performance (motor coordination) w...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(02)00249-0
更新日期:2002-11-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:As an important medicinal material constituting a variety of traditional Chinese medicine prescriptions, Nepeta angustifolia C. Y. Wu was used as a folk medicine to treat various vascular-related diseases including apoplexia, and cerebral haemorrhage in Tibet, China. Our previous studies ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2020.112771
更新日期:2020-06-12 00:00:00
abstract::Achyrocline satureioides (Lam.) DC. inflorescences have been used as remedies in folk medicine for the treatment of a variety of human ailments, particularly those of the gastrointestinal tract. Different extracts of inflorescences have been tested for anti-inflammatory, analgesic, antispasmodic, constipating and seda...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/0378-8741(88)90239-5
更新日期:1988-04-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:It is said that black tea is effective against type 2 diabetes mellitus because it can help modulate postprandial hyperglycemia. However, the mechanism underlying its therapeutic and preventive effects on type 2 diabetes mellitus is unclear. In this study, we focused on the effect of blac...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2014.12.009
更新日期:2015-02-23 00:00:00
abstract:ETHNO-PHARMACOLOGICAL RELEVANCE:Cyperus rotundus L. (Cyperaceae) is a medicinal herb traditionally used to treat various clinical conditions at home such as diarrhea, diabetes, pyresis, inflammation, malaria, and stomach and bowel disorders. Currently, it is one of the most widespread, problematic, and economically dam...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2015.08.012
更新日期:2015-11-04 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The genus Eucomis (Hyacinthaceae) consists of 10 species that are extensively used in African traditional medicine. This review is an appraisal of current information on the distribution and morphology, traditional uses, pharmacology, toxicology and approaches devised to enhance the conse...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2013.11.002
更新日期:2014-01-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The African continent is home to a large number of higher plant species used over centuries for many applications, which include treating and managing diseases such as HIV. Due to the overwhelming prevalence and incidence rates of HIV, especially in sub-Saharan Africa, it is necessary to ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2017.08.005
更新日期:2018-01-10 00:00:00
abstract:UNLABELLED:ETNOPHARMACOLOGICAL RELEVANCE: Aspidosperma cuspa (Kunth) Blake (Apocynaceae) is popularly known as "amargosa" or "cuspa", and its bark is used in folk medicine primarily for pain. AIM OF THE STUDY:In the present study the acute toxicity, antinociceptive effect and alkaloids of the aqueous decoction extract...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2012.07.021
更新日期:2012-09-28 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:In Tanzania, traditional medicine plays a significant role in health care and local economies based on the harvesting, trade and sale of medicinal plant products. The majority of this plant material is said to originate from wild sources, and both traditional healers and vendors are conce...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2018.04.039
更新日期:2018-08-10 00:00:00
abstract:AIM OF THE STUDY:Several extracts of Schinus molle var. areira L. plant proved to be useful for the treatment of different pathologies and for the control of insect pest. Due to these potential uses, it is necessary to study their safety. In this work, we evaluated the effects of subchronic exposure to ethanolic extrac...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2010.08.035
更新日期:2010-10-28 00:00:00
abstract::The aqueous extract of the tuber of Smilax china L., popularly known in China as "jin gang ten", was tested for its anti-inflammatory activities in rats by egg-albumin-induced edema and anti-nociceptive effects in mice using hot-plate test and acetic acid-induced abdominal constriction test, respectively. The aqueous ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2005.08.004
更新日期:2006-02-20 00:00:00
abstract::This study has been carried out in order to evaluate new chemical drugs from plants for biocidal activity before use to avoid noxious effect on human beings and animals or plants and also to prevent the worsing of environment. In fact, many natural products endowed with biological active principles are obtained from p...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2005.11.036
更新日期:2007-12-03 00:00:00
abstract:AIM OF THE STUDY:Evaluations of the anti-snake venom efficacy of Mimosa pudica tannin isolate (MPT) obtained from root of the plant. MATERIALS AND METHOD:MPT was investigated in vitro and in vivo for its efficacy against the venom of Naja kaouthia snake. RESULTS:In vitro: (1) mice injected i.p. with MPT pre-incubated...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2011.05.013
更新日期:2011-09-01 00:00:00
abstract:AIM OF THE STUDY:Red Ginseng roots (Panax ginseng C.A. Meyer) have traditionally been thought to have anti-allergic effects, but their influence on food-induced allergic responses is unclear. MATERIALS AND METHODS:This study examined the effects of a Red Ginseng extract on an ova-albumin (OVA)-evoked allergic reaction...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2010.08.012
更新日期:2010-10-28 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Erythrina variegata, commonly referred to as 'Indian coral tree' belongs to the Fabaceae family. It is a plant native to the coast of India, China and is distributed in tropical and subtropical regions worldwide. In traditional medicine, E. variegata is known to exhibit anxiolytic and ant...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2019.112280
更新日期:2020-02-10 00:00:00
abstract::Drimys angustifolia Miers. (Winteraceae) is a Brazilian medicinal plant used as analgesic, antiulcer and anti-inflammatory without studies to assure its efficacy and safety Leaf and stem bark extracts were evaluated to determine the antiulcer, analgesic, antiinflammatory and antioxidant activities. Preliminary toxic e...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2006.12.025
更新日期:2007-05-22 00:00:00
abstract::The herbal formulation Si-Jun-Zi-Tang reduced the decrease of leukocytes, erythrocytes, thrombocytes and hematocrit in irradiated mice. In general, its protection was more effective in leukocytes and thrombocytes than other hematocytes. Protection of bone marrow stem cells by Si-Jun-Zi-Tang was markedly enhanced by in...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(96)01450-x
更新日期:1996-11-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The root of Peucedanum japonicum Thunberg is traditionally used to treat coughs, colds, headache and inflammatory diseases in Korea and Japan. Its effects on allergic lung inflammation have not been investigated. AIM OF THE STUDY:To investigate the anti-asthmatic effects of Peucedanum ja...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2017.09.006
更新日期:2018-01-30 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:From ancient time human beings have used different plants, animals and minerals to prevent and treat various diseases. In this respect, plants have been of particular importance. Ethnobotany is the science of reviewing how indigenous people and local tribes have used their regional plants...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2014.04.003
更新日期:2014-05-28 00:00:00
abstract::Plants from Northern Nigeria with a history of use in both human and veterinary traditional medicine have been investigated for their antiviral activity and their cytotoxicity determined. Extracts were tested against poliovirus, astrovirus, herpes simplex viruses and parvovirus, using the microtitre plate inhibition t...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(99)00049-5
更新日期:1999-12-15 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Ilex cornuta Lindl. et Paxt. (Aquifoliaceae family) belongs to the Ilex genus. The leaves of this plant are used for the popular herbal tea "Ku-Ding-Cha" in China due to their health benefits for sore throat, obesity and hypertension. Our previous studies have shown that the extract of Il...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2020.113691
更新日期:2021-04-06 00:00:00