当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > A double-blind randomized placebo-controlled clinical study to evaluate the efficacy and safety of a polyherbal formulation in geriatric age group: a phase IV clinical report.

A double-blind randomized placebo-controlled clinical study to evaluate the efficacy and safety of a polyherbal formulation in geriatric age group: a phase IV clinical report.

Abstract：

AIM OF THE STUDY:We sought to determine the efficacy as antioxidant and safety profile of the polyherbal formulation in geriatric patients of eastern India. MATERIALS AND METHODS:The study was double-blind, randomized including placebo controlled and was approved by the ethical committee of SSKM hospital. Geriatric patients attending the OPD (outpatient department) of SSKM hospital formed the study group. The patients were randomized to receive either the polyherbal formulation or the identical-looking placebo at a dose of 2 tablets twice daily for a period of 6 months. Follow-up of patient status was done monthly. The clinical parameters were assessed before and after 6 months of medication or placebo intake. RESULTS:The results showed that significant rejuvenation of the anti-oxidant property which is determined by the enzymatic and non enzymatic anti oxidants, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, reduced glutathione and malondialdehyde in the geriatric patients were seen in patients treated with Geriforte tablets as compared to patients treated with placebo and control group. There were no significant adverse effects experienced by cases in any group. CONCLUSION:Polyherbal formulation is effective in rejuvenating geriatric age group compared to the placebo. This formulation is safe and compliance to the treatment was good. In ancient Ayurveda the constituents of polyherbal formulation were prescribed for different diseases including cardiological, neurological, sepsis, etc.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Banerjee P,Maity S,Das T,Mazumder S

doi

10.1016/j.jep.2010.12.044

subject

Has Abstract

pub_date

2011-03-24 00:00:00

pages

429-33

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(10)00920-7

journal_volume

134

pub_type

杂志文章,随机对照试验

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Prevention of hepatic injury by a traditional Chinese formulation, BJ-JN, in mice treated with Bacille-Calmette-Guérin and lipopolysaccharide.

    abstract：:The hepatoprotective effects of BJ-JN (a traditional Chinese formulation) were evaluated in Bacille-Calmette-Guérin and lipopolysaccharide (BCG/LPS)-induced immunological liver injury (ILI) in mice. BJ-JN (0.75, 1.5, 3 g/kg) was administered via gavage daily for 10 days. Liver index (liver weight/body weight), serum l...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.04.006

    authors： Zou Y,Yang Y,Li J,Li W,Wu Q

    更新日期：2006-10-11 00:00:00

  • In vitro antiplasmodial activity of selected Luo and Kuria medicinal plants.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Drug resistance in malaria is a recurring subject that threatens public health globally. There is an urgent need to seek new antimalarial agents. This study seeking new antimalarials from medicinal plants is guided by ethnobotany. MATERIALS AND METHODS:Medicinal plants of the Luo and Kur...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.09.045

    authors： Owuor BO,Ochanda JO,Kokwaro JO,Cheruiyot AC,Yeda RA,Okudo CA,Akala HM

    更新日期：2012-12-18 00:00:00

  • Effect of a traditional syrup from Citrus medica L. fruit juice on migraine headache: A randomized double blind placebo controlled clinical trial.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In Persian ethnomedicine several herbal remedies and functional foods have been used to treat migraine headache which are mostly summarized in Qarabadin-e-kabir (Aghili-Shirazi MH, 1773). One of them is Citron syrup (Sharbat-e-Balang) containing edible Citrus medica L. fruit juice and sug...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jep.2015.12.040

    authors： Jafarpour M,Yousefi G,Hamedi A,Shariat A,Salehi A,Heydari M

    更新日期：2016-02-17 00:00:00

  • Holistic quality evaluation of Qingwen Baidu Decoction and its anti-inflammatory effects.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Qingwen Baidu Decoction (QBD), a famous traditional Chinese medicine prescription with heat-clearing and detoxifying efficacies, is widely used in the treatment of inflammatory diseases. However, due to lack of holistic quality evaluation research, the further study on the detailed molecu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113145

    authors： Zheng Y,Liu S,Fan C,Zeng H,Huang H,Tian C,Lu Z,Cao H,Liu J,Yu L

    更新日期：2020-12-05 00:00:00

  • Antitrichomonal action of emodin in mice.

    abstract：:Emodin, an active component contained in the root and rhizome of Rheum palmatum L. (Polygonaceae), was found to have an inhibitory effect on the pathogenicity of Trichomonas vaginalis in mice. Emodin delayed the development of subcutaneous abscesses due to infection of this parasite. Also, it cures the intravaginal in...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(93)90055-a

    authors： Wang HH

    更新日期：1993-10-01 00:00:00

  • Ethnobotanical survey of medicinal plants used in the Maseru district of Lesotho.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ethnobotanical knowledge in Lesotho is passed on orally from one generation to another. As a result it has not been well documented. Existing publications have relied on previous literature and are limited either in terms of scope or coverage. Furthermore, some of them are out of print. T...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.04.047

    authors： Seleteng Kose L,Moteetee A,Van Vuuren S

    更新日期：2015-07-21 00:00:00

  • Free radical scavenging and hepatoprotective activity of jigrine against galactosamine induced hepatopathy in rats.

    abstract：:Jigrine a polypharmaceutical herbal hepatoprotective formulation containing aqueous extracts of 14 medicinal plants is used in Indian system of medicine (Unani). Jigrine was evaluated for its hepatoprotective activity against galactosamine induced hepatopathy in rats. Galactosamine induced hepatotoxicity resembles hum...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.12.016

    authors： Najmi AK,Pillai KK,Pal SN,Aqil M

    更新日期：2005-03-21 00:00:00

  • Biological and chemical study of paico (Chenopodium chilense, Chenopodiaceae).

    abstract：:The methanolic extract of the aerial portion of Chenopodium chilense Schrad., used in Chilean traditional medicine as a remedy for stomach-ache, has been found to exert the major spasmolytic activity in acetylcholine contracted rat ileum. This extract, with a complex flavonoid patterns on thin layer chromatography (TL...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(97)00049-4

    authors： García R,Lemus I,Rivera P,Erazo S

    更新日期：1997-07-01 00:00:00

  • Acute intraperitoneal and oral toxicity of the leaf glycosidic extract of Trigonella foenum-graecum in mice.

    abstract：:The present study was carried out to determine the acute toxicity of the leaf glycosidic extract of Trigonealla foenum-graecum by estimation of its medium lethal dose (LD(50)) after oral and intraperitoneal administration to mice and also to identify the target organs for its possible toxic effects. The main target or...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(99)00109-9

    authors： Abdel-Barry JA,Al-Hakiem MH

    更新日期：2000-04-01 00:00:00

  • Antinociceptive and hypnotic properties of Celastrus orbiculatus.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Celastrus orbiculatus, a woody vine of the Celastraceae family, has been widely used as a traditional medicine for the treatment of many diseases, including rheumatoid arthritis and odontalgia. In this study, we assessed the sedative and antinociceptive activities of the methanolic extrac...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.07.052

    authors： Park HJ,Cha DS,Jeon H

    更新日期：2011-10-11 00:00:00

  • Alibertia edulis (L.C. Rich.) A.C. Rich - A potent diuretic arising from Brazilian indigenous species.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Although Alibertia edulis (L.C. Rich.) A.C. Rich decoction is used in Brazilian folk medicine due to its possible antihypertensive effect, this species has never been critically investigated as a hypotensive drug. So, the aim of this study was to evaluate the possible hypotensive and anti...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.12.024

    authors： de Santana Aquino DF,Signor Tirloni CA,Tolouei Menegati SE,Lima Cardoso CA,Heredia Vieira SC,Carmo Vieira MD,Simonet AM,Macías FA,Gasparotto A Junior

    更新日期：2017-01-20 00:00:00

  • Anti-inflammatory activity of oleoresin from Brazilian Copaifera.

    abstract：:The oleoresin from Brazilian Copaifera species yielded copalic acid and sesquiterpenes and showed marked anti-inflammatory activity using various experimental models in rats. The oleoresin significantly inhibited carrageenin-induced pedal edema following oral doses from 0.70 to 2.69 ml/kg, but was somewhat less effect...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(88)90235-8

    authors： Basile AC,Sertié JA,Freitas PC,Zanini AC

    更新日期：1988-01-01 00:00:00

  • Effect and putative mechanism of action of ginseng on the formation of glycated hemoglobin in vitro.

    abstract：:As a non-enzymatic, covalent binding between glucose and protein, glycation is a well-known cause of various forms of diabetic complications. This study was undertaken to determine the effect and mechanism of action of ginseng on the formation of glycated protein. A solution containing hemoglobin and glucose was incub...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.12.008

    authors： Bae JW,Lee MH

    更新日期：2004-03-01 00:00:00

  • Danggui Buxue Tang promotes the adhesion and migration of bone marrow stromal cells via the focal adhesion pathway in vitro.

    abstract：ETHNOPHARMACOLOGY RELEVANCE:Danggui Buxue Tang has been used in China to treat clinical anemia for more than 800 years. However, there is no scientific report on its effect on bone marrow stromal cells. AIM OF THE STUDY:Here, we aimed to explore the effect of Danggui Buxue Tang on bone marrow stromal cell adhesion and...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.11.018

    authors： Bo H,He J,Wang X,Du R,Bei H,Chen J,Wang J,Wu F,Zhang W,Chen Q

    更新日期：2019-03-01 00:00:00

  • Toxicological studies on the ethanolic extract of Crotalaria juncea seeds in rats.

    abstract：:The effect of the ethanolic extract of Crotalaria juncea Linn. (Leguminosae) seeds has been assessed on liver, kidney, spleen and adrenals of adult rats. Results revealed that its administration at a dose of 200 mg/kg caused significant alterations. Wet weight of the organs was reduced. Protein and glycogen contents i...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(94)01211-h

    authors： Prakash AO,Dehadrai S,Jonathan S

    更新日期：1995-03-01 00:00:00

  • Genus Gentiana: A review on phytochemistry, pharmacology and molecular mechanism.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:As the largest genus of Gentianaceae family, the Gentiana genus harbors over 400 species, widely distributed in the alpine areas of temperate regions worldwide. Plants from Gentiana genus are traditionally used to treat a wide variety of diseases including easing pain dispelling rheumatis...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113391

    authors： Jiang M,Cui BW,Wu YL,Nan JX,Lian LH

    更新日期：2021-01-10 00:00:00

  • Triptolide promotes generation of FoxP3+ T regulatory cells in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Triptolide (TPT), a component of the Chinese herb Triptergium wilfordii, has potent immunosuppressive and anti-inflammatory activity and is used clinically in recipients of kidney transplantation. AIM OF THE STUDY:This work aimed to investigate the effect of TPT on the differentiation of...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.06.020

    authors： Zhang G,Liu Y,Guo H,Sun Z,Zhou YH

    更新日期：2009-08-17 00:00:00

  • Ghana's herbal market.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plant markets not only provide a snapshot of a country's medicinal flora, they also reflect local health concerns and the importance of traditional medicine among its inhabitants. This study aimed to describe and quantify the Ghanaian market in herbal medicine, and the diversity...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.01.028

    authors： van Andel T,Myren B,van Onselen S

    更新日期：2012-03-27 00:00:00

  • Evaluation of some pharmacological activities of Eugenia uniflora L.

    abstract：:In view of the extensive use of Eugenia uniflora in folk medicine, different extracts of dried and fresh leaves of the plant were assayed to test its possible pharmacological activities. The infusion of fresh leaves had a highly significant anti-inflammatory effect when administered p.o. to rats 1 h before subplantar ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(94)01178-8

    authors： Schapoval EE,Silveira SM,Miranda ML,Alice CB,Henriques AT

    更新日期：1994-12-01 00:00:00

  • Guaraná (Paullinia cupana var. sorbilis): ecological and social perspectives on an economic plant of the central Amazon basin.

    abstract：:Guaraná is considered an ideal crop for supplementing the incomes of small peasant farmers in the Amazon basin. A fast-growing perennial, guaraná can be planted in the midst of manioc crops, allowing the formation of extensive orchards in the place of regenerating scrub once the manioc has been harvested. Traditional ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(82)90054-x

    authors： Henman AR

    更新日期：1982-11-01 00:00:00

  • Potential of medicinal plants from the Brazilian semi-arid region (Caatinga) against Staphylococcus epidermidis planktonic and biofilm lifestyles.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants from the Caatinga, a Brazilian xeric shrubland, are used in folk medicine to treat infections. These ethnopharmacological data can contribute to obtaining new antimicrobial/antibiofilm extracts and natural product prototypes for the development of new drugs. The aim of th...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.05.030

    authors： Trentin Dda S,Giordani RB,Zimmer KR,da Silva AG,da Silva MV,Correia MT,Baumvol IJ,Macedo AJ

    更新日期：2011-09-01 00:00:00

  • Reactive oxygen species mediation of baizhu-induced apoptosis in human leukemia cells.

    abstract：:Baizhu (Atractylodes macrocephala Koidz) has traditionally been used as an important ingredient of several Chinese herbal medicines, which have been used for abdominal pain and gastroenterology diseases for thousands of years. Despite its popularity in herbal therapies, little is known about the anticancer effect of B...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.09.058

    authors： Huang HL,Chen CC,Yeh CY,Huang RL

    更新日期：2005-02-10 00:00:00

  • Lippia: traditional uses, chemistry and pharmacology: a review.

    abstract：:The chemical composition, pharmacological activity and traditional uses of 52 species attributed to the genus Lippia (Verbenaceae) as used in the South and Central America, and Tropical Africa, were revised and compared. A survey of the available literature shows that these species are used mostly for the treatment of...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s0378-8741(01)00234-3

    authors： Pascual ME,Slowing K,Carretero E,Sánchez Mata D,Villar A

    更新日期：2001-08-01 00:00:00

  • Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.

    abstract：AIM:Zhi Zhu Wan (ZZW) is a classical Chinese medical formulation used for the treatment of functional dyspepsia that attributed to Spleen-deficiency Syndrome. ZZW contains Atractylodes Rhizome and Fructus Citrus Immaturus, the later originates from both Citrus aurantium L. (BZZW) and Citrus sinensis Osbeck (RZZW). The ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.02.005

    authors： Cao H,Chen X,Sun H,Sakurai T,Zhou J,Sun W,Lv H,Wang X

    更新日期：2010-04-21 00:00:00

  • Chemical characterization and evaluation of gastric antiulcer properties of the hydroethanolic extract of the stem bark of Virola elongata (Benth.) Warb.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Virola elongata is a tree species belonging to the Myristicaceae family, distributed in the North and Midwest regions of Brazil, in the phytogeographic domain of the Amazon. The aqueous infusion or the hydroethanolic macerate of the stem bark of V. elongata are used in Brazilian and Ecuad...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.11.011

    authors： Almeida GVB,Arunachalam K,Balogun SO,Pavan E,Ascêncio SD,Soares IM,Zanatta AC,Vilegas W,Macho A,Oliveira Martins DT

    更新日期：2019-03-01 00:00:00

  • Antimicrobial activity of Acalypha siamensis Oliv. ex Gage.

    abstract：:The hexane, dichloromethane, ethyl acetate and methanol fractions of leaves of Acalypha siamensis Oliv. ex Gage were evaluated for antibacterial and antifungal activity. The antibacterial activity was more pronounced in the ethyl acetate and methanol extracts. No activity was shown against tested moulds. ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.07.014

    authors： Wiart C,Hannah A,Yassim M,Hamimah H,Sulaiman M

    更新日期：2004-12-01 00:00:00

  • Antinociceptive activity of ethanolic extract and isolated compounds of Urtica circularis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Urtica circularis (Hicken) Sorarú is a medicinal plant commonly used in traditional medicine to relieve pain in inflammatory processes. AIM OF THE STUDY:In the present study, the in vivo antinociceptive effect of Urtica circularis ethanolic extract and its isolated compounds has been inv...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.01.025

    authors： Gorzalczany S,Marrassini C,Miño J,Acevedo C,Ferraro G

    更新日期：2011-04-12 00:00:00

  • The evaluation of hepatoprotective effects of Taiwan folk medicine 'teng-khia-u'.

    abstract：:'Teng-khia-u' is a folk medicine of Taiwan, derived from the entire plants of Elephantopus scaber L., E. mollis H.B.K. and Pseudoelephantopus spicatus (Juss.) Rohr. The hepatoprotective effects of water extracts of these three plants against beta-D-galactosamine (D-GalN)- and acetaminophen (APAP)-induced acute hepatic...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(94)01198-9

    authors： Lin CC,Tsai CC,Yen MH

    更新日期：1995-02-01 00:00:00

  • Immunomodulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidum.

    abstract：:The immunomodulatory effect of Ganoderma lucidum immunomodulating substance (GLIS) on macrophages has been investigated as part of on-going research into the anti-cancer properties of Ganoderma lucidum. Proliferation of bone marrow macrophages (BMMs) was enhanced by GLIS in a dose-dependent manner. Microscopic examina...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.03.035

    authors： Ji Z,Tang Q,Zhang J,Yang Y,Jia W,Pan Y

    更新日期：2007-07-25 00:00:00

  • Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet region (Province of Errachidia), Morocco.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:We carried out an ethnobotanical survey in Tafilalet region. This region is classified by the UNESCO as a reserve of biosphere and represents an important area with important knowledge of traditional medicine, especially the use of medicinal plants for human healthcare. Furthermore, the g...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.12.017

    authors： Eddouks M,Ajebli M,Hebi M

    更新日期：2017-02-23 00:00:00