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In vitro antiplasmodial activity of selected Luo and Kuria medicinal plants.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Drug resistance in malaria is a recurring subject that threatens public health globally. There is an urgent need to seek new antimalarial agents. This study seeking new antimalarials from medicinal plants is guided by ethnobotany. MATERIALS AND METHODS:Medicinal plants of the Luo and Kuria ethnic groups of Kenya with high usage reports were screened in vitro for their antiplasmodial activity using the SYBR Green I fluorescence assay (MSF assay). RESULTS:The IC50's for drugs and total plant extracts ranged from 0.01217 to 10.679 mg/ml. Extracts were more active on chloroquine sensitive than resistant Plasmodium falciparum strains. Tylosema fassoglense, Ageratum conyzoides and Ocimum kilimandscharicum exhibited promising results. Plectranthus barbatus did not show activity. CONCLUSION:Ethnobotanical knowledge was sufficiently reliable for identifying plant extracts with antiplasmodial activity.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Owuor BO,Ochanda JO,Kokwaro JO,Cheruiyot AC,Yeda RA,Okudo CA,Akala HM

doi

10.1016/j.jep.2012.09.045

subject

Has Abstract

pub_date

2012-12-18 00:00:00

pages

779-81

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(12)00653-8

journal_volume

144

pub_type

杂志文章

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