Abstract：
:The present study was carried out to determine the acute toxicity of the leaf glycosidic extract of Trigonealla foenum-graecum by estimation of its medium lethal dose (LD(50)) after oral and intraperitoneal administration to mice and also to identify the target organs for its possible toxic effects. The main target organ affected among the four organs studied (liver, kidney, stomach, small and large intestine) was the liver, where early degeneration with infiltration of mononuclear and mild hepatitis was found in some animals treated with toxic doses of glycosidic extract. It is concluded that the glycosidic extract of T. foenum-graecum leaves is considered to be safe and have minimal adverse effect.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Abdel-Barry JA,Al-Hakiem MHdoi
10.1016/s0378-8741(99)00109-9keywords:
subject
Has Abstractpub_date
2000-04-01 00:00:00pages
65-8issue
1eissn
0378-8741issn
1872-7573pii
S0378-8741(99)00109-9journal_volume
70pub_type
杂志文章abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Qingwen Baidu Decoction (QBD), a famous traditional Chinese medicine prescription with heat-clearing and detoxifying efficacies, is widely used in the treatment of inflammatory diseases. However, due to lack of holistic quality evaluation research, the further study on the detailed molecu...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.113145
更新日期：2020-12-05 00:00:00
abstract：:Many cardiovascular diseases are associated with an increase in blood platelet activity. In Morocco, parsley (Petroselinum crispum, Apiaceae) is one of the medicinal herbs used to treat cardiovascular diseases such as arterial hypertension. In this study, crude aqueous extract (CAE) of parsley was evaluated for its an...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.05.014
更新日期：2009-08-17 00:00:00
abstract：:A combination of spices (Piper nigrum, Piper longum and Zingiber officinale), herbs (Cyperus rotundus and Plumbago zeylanica) and salts make up Amrita Bindu. The study was focused to evaluate the antioxidant property of individual ingredients in Amrita Bindu against the free radical 2,2'-azinobis-(3-ethylbenzothiazoli...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2005.09.043
更新日期：2006-04-21 00:00:00
abstract：ETHNOPHARMCOLOGICAL RELEVANCE:Microbial biofilm formation, a quorum sensing (QS) regulated process, is one of the major causes of nosocomial and chronic infections, foodborne diseases, and associated deaths. Various approaches have been used to eradicate the menace of biofilm. Ethnomedicinal plants as potent antibiofil...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.113699
更新日期：2021-04-06 00:00:00
abstract：:Maharasnadhi Quathar (MRQ) is a polyherbal preparation recommended by Ayurvedic medical practitioners for treatment of arthritic conditions. An investigation has been carried out with rats and human rheumatoid arthritis (RA) patients, to determine the anti-inflammatory and analgesic potential of MRQ. Results obtained ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(03)00016-3
更新日期：2003-04-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ligusticum wallichii has been used to treat renal diseases for thousands of years in China. Ligustrazine (Lig) is the active ingredient of Ligusticum wallichii that possesses a variety of biological activities against kidney disease. AIM OF THE STUDY:The purpose of this review is to furt...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,meta分析
doi：10.1016/j.jep.2020.112568
更新日期：2020-04-24 00:00:00
abstract：UNLABELLED:Morinda citrifolia Linn (syn. Noni) is a plant widely used as food and medicine worldwide but there are no toxicological tests about this plant focused on reproduction. AIM OF THE STUDY:To investigate possible endocrine activity and toxic effect on the reproductive system of Wistar rats by exposure of aqueo...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2008.10.019
更新日期：2009-01-21 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Calotropis gigantea R.Br. (Asclepiadaceae) is a perennial undershrub found chiefly in wastelands throughout India. It has been reported as a traditional folkloric medicine for a variety of alignments. The plant Calotropis gigantea is also used in some parts of India for wound healing in c...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.06.007
更新日期：2009-08-17 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Oryeongsan (ORS, Wulingsan) has been reported to possess renal protective effects from renal diseases such as diabetes-induced renal damage, and nephrocalcinosis. AIM OF THE STUDY:This study was conducted to evaluate the quantitative analysis and the inhibitory effect of ORS on hypertoni...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2016.03.030
更新日期：2016-06-05 00:00:00
abstract：:Ginseng, Panax ginseng C.A. Meyer, is a well-known Chinese traditional medicine. There have been more than 300 original papers in Chinese and in English during the last 10 years in China. This review paper summarizes some achievements from some of these published papers. Twenty-eight ginsenosides and some minor consti...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/0378-8741(92)90057-x
更新日期：1992-02-01 00:00:00
abstract：AIM OF STUDY:Yuanhu Zhitong prescription that consists of Corydalis yanhusuo and Radix Angelicae dahuricae has been used for the treatment of gastralgia, costalgia, headache and dysmenorrhea in Traditional Chinese Medicine. Our previous studies demonstrated that Corydalis alkaloid (CA, derived from the root of Corydali...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.03.005
更新日期：2010-05-04 00:00:00
abstract：:The root bark of Brosimum gaudichaudii Trécul (Moraceae) is popularly used for treatment of vitiligo. In the present study the mutagenic activity of the aqueous and methanolic extract as well as of the n-butanolic fraction of this medicinal plant were evaluated using Salmonella typhimurium assays, TA100, TA98, TA102 a...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(02)00089-2
更新日期：2002-07-01 00:00:00
abstract：:Traditional Korean medicine, Cheongyeolsaseuptang (CYSST) has been widely applied as a treatment of rheumatoid arthritis (RA) in Korea. However, its effect in experimental models remains unknown. Recent reports suggest that in patients with RA, synovial mast cells increase in number and show signs of activation and pr...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2004.10.018
更新日期：2005-02-10 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Gochnatia polymorpha ssp. floccosa (Asteraceae) also known as ''Cambará'' is used as medicinal plant in Brazil to treat infections and inflammation. Previous studies showed that its ethanolic extract could be bioprospecting of a new anti-inflammatory phytotherapy for use during pregnancy....
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.02.042
更新日期：2017-03-22 00:00:00
abstract：:The present study indicates the efficacy of extracts and fractions of Quercus lusitania var. infectoria galls (Oliv.) as larvicidal agents and their possible use in biological control of Culex pipiens, the urban nuisance mosquito. Extracts and fractions were tested against second and fourth instar larvae. The LC(50) v...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(01)00390-7
更新日期：2002-02-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Maytenus ilicifolia Mart. ex. Reissek (Celastraceae) is widely used in Brazilian folk medicine to treat gastric disturbances. AIM OF THE STUDY:This work intended to characterize the effects of Maytenus ilicifolia on gastrointestinal motility. MATERIALS AND METHODS:Gastric emptying and i...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.03.037
更新日期：2009-06-25 00:00:00
abstract：UNLABELLED:ETHONOPHARMACOLOGICAL RELEVANCES: Traditional medicines have long been used by the Thai people. Several medicinal recipes prepared from a mixture of plants are often used by traditional medicinal practitioners for the treatment of many diseases including cancer. The recipes collected from the Thai medicinal ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2012.03.010
更新日期：2012-05-07 00:00:00
abstract：ETHNOPHARMACOLOGY RELEVANCE:Dendropanax morbifera Leveille (DM) has been used in traditional medicines for infectious and skin diseases, and dysmenorrhea. It exhibits a diverse therapeutic potential including anti-cancer, anti-thrombotic, anti-diabetic, anti-oxidant, and anti-inflammatory activities. AIM OF THE STUDY:...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2019.111874
更新日期：2019-06-28 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cortex Phellodendri is derived from the dried bark of Phellodendron chinense Schneid. or Phellodendron amurense Rupr. Traditionally, Cortex Phellodendron Chinensis (CPC) and Cortex Phellodendron Amurensis (CPA) are used interchangeably under the name "Huang Bai" for the treatment of gastr...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2011.08.014
更新日期：2011-10-11 00:00:00
abstract：:The hepatoprotective effects of rubiadin, a major constituent isolated from Rubia cordifolia Linn., were evaluated against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Rubiadin at a dose of 50, 100 and 200 mg/kg was administered orally once daily for 14 days. The substantially elevated serum enzymatic a...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2005.08.073
更新日期：2006-02-20 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Helichrysum (Asteraceae) flowers, known as "altın otu, yayla çiçeği, kudama çiçeği" , are widely used to remove kidney stones and for their diuretic properties in Turkey. AIM OF THE STUDY:To determine the curative effect of infusions prepared from capitulums of Helichrysum graveolens (M....
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2016.04.003
更新日期：2016-06-20 00:00:00
abstract：:Catha edulis is a plant that grows in certain areas of East Africa and the Arab Peninsula. The stimulating properties of fresh material were described more than seven centuries ago and today the habit of inducing a state of euphoria and subjective well-being by chewing Catha edulis prevails among the inhabitants of th...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(93)90039-8
更新日期：1993-08-01 00:00:00
abstract：:Achyrocline satureioides (Lam.) DC (Marcela) is known to possess a broad spectrum of pharmacological, medicinal and therapeutic properties. Previous studies have demonstrated various protective abilities of the marcela extracts against various pathological conditions. However, no extensive safety studies have been con...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2004.08.013
更新日期：2004-12-01 00:00:00
abstract：:Humulus lupulus (hops) is traditionally used as a tranquilizing herbal remedy. Here, we investigated the in vivo and in vitro effect of hop beta-acids on central nervous system function. Oral administration of beta-acids (5-10mg/kg) in rats produced an increased exploratory activity in the open field, a reduction in t...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2006.07.008
更新日期：2007-01-03 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Banana is a fruit with nutritional properties and also with acclaimed therapeutic uses, cultivated widely throughout the tropics as source of food and income for people. Banana peel is known by its local and traditional use to promote wound healing mainly from burns and to help overcome o...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2014.11.008
更新日期：2015-02-03 00:00:00
abstract：ETHNOPHARMACOLOGIC RELEVANCE:Lavandula angustifolia Mill (lavender) odor was traditionally used as sleep enhancer. Previous studies have shown interaction between insomnia, quality of life and control of diabetes mellitus (DM). Insomnia is suggested to increase the risk of depression and decrease the quality of life in...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112560
更新日期：2020-04-06 00:00:00
abstract：:Oral administration of root extract of Barleria prionitis L. to male rats (100 mg/rat per day) for the period of 60 days did not cause body weight loss. The root extract brought about an interference with spermatogenesis. The round spermatids were decreased by 73.6% (P< or =0.001). No significant change was found in t...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(99)00150-6
更新日期：2000-05-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The roots and rhizomes of Smilax riparia (SR), called "Niu-Wei-Cai" in traditional Chinese medicine (TCM), are believed to be effective in treating hyperuricemia and gout symptoms. This study was designed to isolate a saponin glycoside named pallidifloside D from the total saponins of Smi...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2014.09.034
更新日期：2014-11-18 00:00:00
abstract：:Coca leaves (Erythroxylum coca Lamarck) and powder (5 - 10 g) were taken orally by human subjects in the same way as South American natives do. The cocaine, as measured by mass fragmentography, was immediately detected in the blood, reached peak concentrations from 10 - 150 ng/ml plasma at 0.38 - 1.95 hours, and persi...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(79)90017-5
更新日期：1979-01-01 00:00:00
abstract：:Cedronin was isolated from Simaba cedron Planchon (Simaroubaceae), a species popularly believed in South America to have antimalarial properties. It was examined for in vitro and in vivo antimalarial activities and for cytotoxicity against KB cells. Experimental results showed that cedronin was active against chloroqu...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(94)90117-1
更新日期：1994-06-01 00:00:00
