Abstract:
:Seventy-seven crude extracts from leaves and stem barks of 15 Gabonese plants used in traditional medicine were evaluated for their cytotoxic, antileishmanial and antifungal activities. Most of the extracts exhibited cytotoxic activities toward human monocytes, and most particularly the hydromethanolic 50% (v/v) fraction of Ganophyllum giganteum leaves (IC(50)=1.3 microg/ml) as well as the methanolic extracts of Polyalthia suaveolens, Dioscorea preussii, Augouardia letestui leaves and Cola lizae stem barks (IC(50)<5 microg/ml). The methanolic extract of Polyalthia suaveolens displayed a strong antiproliferative activity against the promastigote form of Leishmania infantum parasites and presented a good antifungal activity on all the tested strains (IC(50)<1mg/ml). This extract was divided into six fractions: fraction F6 demonstrated a cytotoxic activity stronger than those of the crude extract (IC(50)=0.6 microg/ml), fractions F4 and F5 were devoid of cytotoxicity (IC(50)>100 microg/ml) and displayed interesting antileishmanial activity against the intracellular amastigote form of the parasite (IC(50)=5.6 and 12.4 microg/ml), respectively. However, the antifungal activity observed for the crude extract could not be recovered in the corresponding fractions.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Lamidi M,DiGiorgio C,Delmas F,Favel A,Eyele Mve-Mba C,Rondi ML,Ollivier E,Nze-Ekekang L,Balansard Gdoi
10.1016/j.jep.2005.06.011keywords:
subject
Has Abstractpub_date
2005-11-14 00:00:00pages
185-90issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(05)00375-2journal_volume
102pub_type
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