Abstract：
:Bioassay-directed fractionation of the methanolic extract of seeds of Casimiroa edulis led to the isolation of seven constituents with cardiovascular activity, namely the new compound synephrine acetonide and the known compounds N-monomethylhistamine, N,N-dimethylhistamine, proline, N-methylproline, gamma-aminobutyric acid and casimiroedine. In anesthetized rats, both histamine derivatives produced transient hypotension mediated via H1-histaminergic receptors and in the case of N,N-dimethylhistamine, via nitric oxide release. Synephrine acetonide produced transient hypertension and tachycardia, mediated via alpha- and alpha- and beta-adrenergic receptores, respectively. The chromatographic zone containing N-methyproline, proline and gamma-aminobutyric acid elicited marked and prolonged hypotension. Finally, casimiroedine did not modify the blood pressure of anesthetized rats, but lowered it persistently in anesthetized guinea pigs. It was concluded that hypotension produced by C. edulis is due to several active components. The immediate effect can be attributed to the histamine derivatives acting on H1-receptors. More prolonged hypotension would be produced by the mixture of amino acids through an unknown mechanism, as well as by casimiroedine, possibly by activation of H3-receptors. Hypotension is partially offset by synephrine acetonide through adrenergic mechanisms.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Magos GA,Vidrio H,Reynolds WF,Enríquez RGdoi
10.1016/s0378-8741(98)00101-9keywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
35-44issue
1eissn
0378-8741issn
1872-7573pii
S0378874198001019journal_volume
64pub_type
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journal_title：Journal of ethnopharmacology
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更新日期：2017-03-06 00:00:00
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journal_title：Journal of ethnopharmacology
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abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Pistachio hull has traditionally been used to treat peptic ulcer, hemorrhoids, oral and cutaneous wounds. AIM OF THE STUDY:On the basis of its traditional uses and previous pharmacological reports, a bioassay guided fractionation procedures on pistachio (Pistacia vera L.) hulls was perfo...
journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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更新日期：1988-02-01 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2016-02-17 00:00:00
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pub_type： 杂志文章
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更新日期：2011-03-08 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(91)90066-m
更新日期：1991-12-01 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2015-08-02 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,随机对照试验
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2001-08-01 00:00:00
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更新日期：2009-06-22 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2011-09-01 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2007-09-25 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2000-10-01 00:00:00
abstract：:The use of herbal medicine in Jordan is very common. In order to evaluate the knowledge and the attitudes of the herbalists and acquire the common and less common medicinal herbs sold by the Jordanian herbalists, more than 100 herbalists throughout the country were interviewed and data concerning herbs present in thei...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Origanum majorana L. (Lamiaceae) is commonly used in Moroccan folk medicine to treat infantile colic, abdominal discomfort and diarrhea. Liquid stools and abdominal discomfort observed in acute infectious diarrhea are the consequences of imbalance between intestinal water secretion and ab...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2018.09.005
更新日期：2019-07-15 00:00:00
