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Selective Th1 upregulation by ethyl acetate fraction of Labisia pumila.

Abstract：

AIM OF THE STUDY:Labisia pumila has rejuvenating properties that help women to regain the strength and vigour after giving birth (Burkill, 1935) leading us to speculate that Labisia pumila might also modulate the immune matrix as it is one of the important aspect of healthy state of the living body. MATERIALS AND METHODS:Studies were carried out for the evaluation of pro-inflammatory cytokines in murine neutrophils followed by expression of T cell-surface markers and corresponding intracellular expression of cytokines related to T helper1 (Th1) and T helper 2 (Th2) activity. RESULTS:The ethyl acetate fraction (A001/3b) obtained from ethanolic extract of leaves of Labisia pumila at graded doses (in vitro) showed increased expression of TNF-α, IL-6 and IL-12. IL-12 is a strong inducer of Th1 response in activated CD4+ T cells and accordingly T cell studies were carried out (in vivo). These specific studies showed A001/3b to cause marked stimulation of CD4+ T helper cells and related cytokine expression like IL-2 and IFN-gamma (a potent Th1 inducer), thereby, having a predominant Th1 upregulation pathway. This was further validated by suppression of IL-4 and IL-10 expression which are the Th2 pathway cytokines. CONCLUSION:This study showed ethyl acetate fraction (A001/3b) of Labisia pumila to have Th1 upregulating activity and suggests its possible usefulness as a therapeutic agent in immune compromised patients.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Pandey A,Bani S,Sangwan P,Koul S

doi

10.1016/j.jep.2010.08.039

subject

Has Abstract

pub_date

2010-10-28 00:00:00

pages

309-15

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(10)00586-6

journal_volume

132

pub_type

杂志文章

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