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Cytotoxic and genotoxic effects of aqueous extracts of five medicinal plants on Allium cepa Linn.

Abstract：

:The cytotoxic and genotoxic effects of aqueous extracts of five medicinal plants: Azadirachta indica (A. Juss), Morinda lucida (Benth.), Cymbopogon citratus (DC Stapf.), Mangifera indica (Linn.) and Carica papaya (Linn.) was evaluated using the Allium cepa assay. The extracts were prepared with tap water as practised locally. Onion bulbs were exposed to 1, 5, 10, 25 and 50%; and 1, 2.5, 5, 10 and 20% concentrations (v/v) of each of the extracts for macroscopic and microscopic analyses, respectively. There was concentration-dependent and statistically significant (P<0.05) inhibition of root growth by the extracts when compared with the control. The EC(50) obtained for decoctions of Azadirachta indica. Cymbopogon citratus, Mangifera indica and Carica papaya were 0.6, 3.0, 1.4 and 0.8%, respectively. It was 2.6 and 0.8% for the squeezed extracts of Azadirachta indica and Morinda lucida, respectively. All the tested extracts were observed to have mitodepressive effects on cell division and induced mitotic spindle disturbance in Allium cepa. These results suggest an inhibitory, mitodepressive and turbagenic activities of the aqueous extracts on Allium cepa.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Akinboro A,Bakare AA

doi

10.1016/j.jep.2007.04.014

subject

Has Abstract

pub_date

2007-07-25 00:00:00

pages

470-5

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(07)00206-1

journal_volume

112

pub_type

杂志文章

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