Abstract：
:Magnolia dealbata Zucc. is considered to have tranquilizer and anticonvulsant properties in Mexican traditional medicine. In the present study we report the effects of a crude extract of Magnolia dealbata (30, 100 and 300 mg/kg) on mouse central nervous system (CNS). Pharmacological effects were tested on ambulatory activity, anti-anxiety response, sodium pentobarbital-induced hypnosis and pentylenetetrazole (PTZ)-induced seizures in comparison to honokiol, buspirone, ethosuximide and diazepam as corresponding reference drugs. No changes in spontaneous locomotor activity were produced posterior to Magnolia dealbata administration; however, a significant and dose-dependent diminution in the anxiety response was observed in experimental models such as plus-maze, head-dipping and exploratory rearing tests. Magnolia dealbata not only prolonged the time of sodium pentobarbital-induced hypnosis and delayed the onset of PTZ-induced mioclonus and clonus, but also hindered the presence of tonic seizures and avoided mortality. The hypnotic, anxiolytic and anticonvulsant effects obtained in these experiments support the hypothesis that Magnolia dealbata possesses CNS activity and reinforces the popular use in Mexican traditional medicine.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Martínez AL,Domínguez F,Orozco S,Chávez M,Salgado H,González M,González-Trujano MEdoi
10.1016/j.jep.2006.01.003keywords:
subject
Has Abstractpub_date
2006-06-30 00:00:00pages
250-5issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(06)00005-5journal_volume
106pub_type
杂志文章abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Metabolic syndrome and vascular dysfunction was suggested to be the risk factors for Alzheimer's disease (AD). Xuefu Zhuyu decoction (XZD) is a traditional Chinese medicine used to treat metabolic syndrome and cardiac-cerebral vascular disease. The effects of XZD on ameliorating metabolic...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.07.036
更新日期：2017-09-14 00:00:00
abstract：AIM:To study the chronic toxicity of gambogic acid (GA), the major active ingredient of gamboges, a brownish to orange resin extracted from the Garcinia hanburyi (family Guttiferae) in Southeast Asia, using Sprague-Dawley rat as an animal model and provide further theoretical support for clinical applications of this p...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2008.02.027
更新日期：2008-05-22 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Caesalpinia sappan is a medicinal plant native to China popularly used to treat chronic pelvic inflammation, dysmenorrhea and hysteromyoma. Its main bioactive component is brazilin which had presented antibacterial, anti-inflammatory and anti-platelet aggregation activities. To establish ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2013.08.054
更新日期：2014-01-01 00:00:00
abstract：:The seed oil of Ocimum sanctum was evaluated for chemopreventive activity against subcutaneously injected 20-methylcholanthrene induced-fibrosarcoma tumors in the thigh region of Swiss albino mice. Supplementation of maximal tolerated dose (100 microl/kg body weight) of the oil significantly reduced 20-methylcholanthr...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(00)00194-x
更新日期：2000-09-01 00:00:00
abstract：:In an ethnopharmacological screening of selected medicinal plants used in Nepal, methanol extracts from 20 plant species were assayed for activity against eleven strains of bacteria and four strains of fungi. Duplicate assays were conducted with and without exposure to ultraviolet (UV)-A radiation to test for light-ac...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(95)01335-0
更新日期：1996-02-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis are popular plants used in traditional Chinese medicine to treat diabetes. AIM OF THE STUDY:The aim of the study is to investigate the therapeutic effect of the active components of Euonymus alatus, Radix tricho...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.03.015
更新日期：2017-04-18 00:00:00
abstract：:The present study was carried out to evaluate the effect of dry latex (DL) of Calotropis procera on smooth muscles of gastrointestinal tract. Oral administration of DL to rats (50-1000 mg/kg) produced a dose-dependent decrease in intestinal transit along with a decrease in intestinal content as compared to control gro...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2004.04.013
更新日期：2004-08-01 00:00:00
abstract：UNLABELLED:ETNOPHARMACOLOGICAL RELEVANCE: Aspidosperma cuspa (Kunth) Blake (Apocynaceae) is popularly known as "amargosa" or "cuspa", and its bark is used in folk medicine primarily for pain. AIM OF THE STUDY:In the present study the acute toxicity, antinociceptive effect and alkaloids of the aqueous decoction extract...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2012.07.021
更新日期：2012-09-28 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Synadenium grantii Hook f. has traditionally been used to treat various neoplastic diseases in southern Brazil. AIM OF STUDY:Evaluation of the antitumoural potential of Synadenium grantii latex against B16F10 melanoma cell line using in vitro and in vivo models, as well as a phytochemica...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2013.08.033
更新日期：2013-10-28 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Silybum marianum (L.) Gaertn. or Milk thistle is a medicinal plant native to Northern Africa, Southern Europe, Southern Russia and Anatolia. It also grows in South Australia, North and South America. In traditional knowledge, people have used S. marianum for liver disorders such as hepati...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2020.113303
更新日期：2021-01-30 00:00:00
abstract：AIM OF THE STUDY:Characterization and comparative analysis of the main VOCs (volatile organic compounds) present in the smoke of 11 experimentally combusted plant species used as incense in Shaxi, Southwest China. Substances which may be responsible for the pleasant smell of the smokes as well as substances with a pote...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2011.08.078
更新日期：2011-10-31 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCES:One of the prestigious Thai/Lanna folklore wisdoms is the medicinal plant recipes. Thai/Lanna medicinal plant recipe database MANOSROI III has been developed by Prof. Dr. Jiradej Manosroi. It consists of over 200,000 recipes covering all diseases including cancer. AIM OF THIS STUDY:To i...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2013.06.037
更新日期：2013-08-26 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Serjania marginata Casar. (Sapindaceae) is a species traditionally known to be used for the treatment of gastric pain and inflammatory symptoms. AIM OF THIS STUDY:Due to the therapeutic importance of this species, this study investigated the toxicological effects of S. marginata leaves (...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2018.11.024
更新日期：2019-03-01 00:00:00
abstract：:One of the significant characteristics of traditional Chinese medicine is the use of insects, other terrestrial arthropods and their products as drugs. In the present work, the extract of housefly (Musca domestica) larvae was studied by an agar well diffusion assay and minimum bactericidal concentration (MBC) determin...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2006.11.015
更新日期：2007-05-04 00:00:00
abstract：:The anticholinergic action of Swertia japonica, used in Japan as a bitter stomachic, was examined using in vivo experiments in rats in order to substantiate the presence or absence of antispasmodic properties. The methanol extract of Swertia japonica was found to be an effective anticholinergic given orally. Fractiona...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(91)90157-9
更新日期：1991-05-01 00:00:00
abstract：AIMS OF THE STUDY:This study investigated the anti-inflammatory and analgesic activities, and protoberberine alkaloid contents of ethanol extract of MO roots (MOR(EtOH)). MATERIALS AND METHODS:The analgesic activity of MOR(EtOH) was determined using acetic acid-induced writhing response and formalin test. The anti-inf...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.06.024
更新日期：2009-09-07 00:00:00
abstract：:The present study was planned to investigate the ethnoveterinary methods practiced by the owners of pneumatic-cart pulling camels in Faisalabad Metropolis (Pakistan). During a 7-year-period (November 1992-November 1999), 200 owners of draught camels working in the city were interviewed. Information concerning the ethn...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2004.11.008
更新日期：2005-02-28 00:00:00
abstract：:Strychnos henningsii Gilg is used in African traditional medicine for the treatment of various ailments, including rheumatism, gastrointestinal complaints and snake bites. Different preliminary pharmacological experiments are described. The results show that some of the reported folk medicinal applications of S. henni...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(91)90045-f
更新日期：1991-09-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cassia abbreviata is a small to medium sized branched umbrella-shaped deciduous tree. It is widely spread in the tropics, especially in Africa, having a long history in traditional medicine for the treatment of numerous conditions such as headaches, diarrhea, constipation, some skin disea...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.11.007
更新日期：2018-03-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Bauhinia forficata (BF) has been traditionally used as tea in folk medicine of Brazil for treatment of Diabetes mellitus (DM). AIM OF THE STUDY:To evaluate the effects of BF leaf tea on markers of oxidative damage and antioxidant levels in an experimental model of hyperglycemia in human ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2013.03.070
更新日期：2013-06-21 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Arctium lappa and Tussilago farfara (Asteraceae) are two plant species used traditionally as antitubercular remedies. The aim of this study was (i) to screen Arctium lappa and Tussilago farfara extracts for activity against Mycobacterium tuberculosis and (ii) to isolate and identify the c...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2014.06.034
更新日期：2014-08-08 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Danshen, root of Salvia miltiorrhiza (SM), has been traditionally used in Chinese medicine for the treatment of heart, abdomen, gurgling in the intestines, and relieving fullness. However, the effects of SM on intestine have rarely been done to date. AIM OF THE STUDY:To investigate the c...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2012.05.041
更新日期：2012-08-01 00:00:00
abstract：:Phyllanthus maderaspatensis (whole plant extracts) was evaluated for its antihepatotoxic and choleretic activities in rats. The plant extracts (200 mg/kg, n-hexane, ethyl alcohol or water) showed a remarkable hepatoprotective activity against acetaminophen-induced hepatotoxicity as judged from the serum marker enzymes...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2004.02.005
更新日期：2004-05-01 00:00:00
abstract：AIM OF THE STUDY:A Chinese herbal drug, root of Achyranthes bidentata showed a potent inhibitory activity on bone resorption induced by parathyroid hormone (PTH) in a bone organ culture using neonatal mouse parietal bones. The present study is to clarify the fractions responsible for the activity and further explore th...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.11.016
更新日期：2010-02-03 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Artemisia asiatica Nakai is a traditional herbal plant that has long been used in anti-inflammatory, anti-infective and skin protective remedies. AIM OF THE STUDY:In this study, traditionally known skin-protective activity of Artemisia asiatica Nakai was examined with its ethanol extract...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2018.03.037
更新日期：2018-06-28 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cydonia oblonga Mill. leaves are traditionally used in Uyghur medicine to treat or prevent cardiovascular disease. Beyond a demonstrated effect on thrombosis, we tested it for an effect on dyslipidemia, in a rat model of hyperlipidemia. METHODS:Seventy healthy Sprague Dawley rats were ra...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2013.12.010
更新日期：2014-02-03 00:00:00
abstract：:The antitumour activity of the ethanol extract of Bauhinia variegata (EBV) has been evaluated against Dalton's ascitic lymphoma (DAL) in Swiss albino mice. A significant enhancement of mean survival time of EBV-treated tumour bearing mice was found with respect to control group. EBV treatment was found to enhance peri...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(03)00264-2
更新日期：2003-11-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Indigofera argentea Burm. f.; commonly known as neel, jantari, hathio; is traditionally used for the treatment of headache, fever, inflammation and body pain. Local communities also used this plant for the treatment of malaria, jaundice, vertigo and gastric disorders. AIM OF THE STUDY:Th...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112966
更新日期：2020-09-15 00:00:00
abstract：AIM OF THE STUDY:The stem bark of Terminalia superba (Combretaceae) (TS) is used in traditional Cameroonian medicine as antihypertensive remedy. The aim of this study was to investigate the hypotensive and the antihypertensive effects of the aqueous extract of the stem bark of Terminalia superba. MATERIALS AND METHODS...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.11.016
更新日期：2011-01-27 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Saposhnikovia divaricata (SD), called "Fangfeng" in China, is commonly used in clinical compound prescription for treatment of rheumatoid arthritis (RA), but its actions on RA have not been clarified. The present study aims to determine the anti-inflammatory activity of SD chromone extrac...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2013.05.023
更新日期：2013-07-30 00:00:00
