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In vitro studies on dissolved substance of cinnabar: chemical species and biological properties.

Abstract：

UNLABELLED:Cinnabar is one of traditional Chinese medicines widely used in many Asian countries. It is also a medicine with potential toxicity especially when taking overdose. Up to date, studies on the mechanism of the biological activity of cinnabar were still insufficient. AIM OF THE STUDY:To investigate the possible bioactive species from cinnabar after oral administration, which is the fundamental of biological effects of cinnabar. MATERIALS AND METHODS:Under mimetic intestinal and gastric conditions, the chemical components dissolved from cinnabar were analyzed by infrared spectroscopy (IR) and Raman spectroscopy. Furthermore, binding of mercuric species of cinnabar extractions to human serum protein (HSA) was characterized and their intestinal permeability was determined using the Caco-2 cell monolayer. The cytotoxicity of cinnabar extractions was assessed on human kidney-2 (HK-2) cell. RESULTS:Major dissolved species included mercuric polysulfide (i.e. HgS(2)(OH)(-) and Hg(3)S(2)Cl(2)). The apparent permeability coefficient (P(app)) of mercuric polysulfides was (1.6+/-0.3)x10(-6)cm/s, which is slightly lower than that of mercuric chloride (HgCl(2)). Unlike HgCl(2), mercuric polysulfides exhibited two tightly binding sites to HSA and had little effect on viability of HK-2 cells. CONCLUSION:Mercuric polysulfides, as the major dissolved components, may serve as the active species of cinnabar exhibiting pharmacological and/or toxicological effects.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Zhou X,Zeng K,Wang Q,Yang X,Wang K

doi

10.1016/j.jep.2010.06.018

subject

Has Abstract

pub_date

2010-08-19 00:00:00

pages

196-202

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(10)00416-2

journal_volume

131

pub_type

杂志文章

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