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Inhibitory effects of the Gentiana macrophylla (Gentianaceae) extract on rheumatoid arthritis of rats.

Abstract：

:Acute treatment of rheumatoid rats with an extract from the roots of Gentiana macrophylla (Gentianaceae) produced a significant inhibitory effect on rheumatoid arthritis (RA). When rats were administered the Gentiana macrophylla extract orally at a daily dose of 100 mg/kg body weight, the prostaglandin E(2) (PGE(2)) levels in the inflammatory tissues, sole thickness, and ankle circumferences of feet were significantly decreased. The anti-inflammatory activity observed in Gentiana macrophylla is comparable to that observed in prednisone. These observations suggest that Gentiana macrophylla displays considerable potency in anti-inflammatory action and could be used as an anti-inflammatory agent in the control of inflammation of rheumatoid arthritis.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Yu F,Yu F,Li R,Wang R

doi

10.1016/j.jep.2004.06.025

keywords:

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

77-81

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(04)00312-5

journal_volume

95

pub_type

杂志文章

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