当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Preclinical safety evaluation of the aqueous extract from Mangifera indica Linn. (Anacardiaceae): genotoxic, clastogenic and cytotoxic assessment in experimental models of genotoxicity in rats to predict potential human risks.

Preclinical safety evaluation of the aqueous extract from Mangifera indica Linn. (Anacardiaceae): genotoxic, clastogenic and cytotoxic assessment in experimental models of genotoxicity in rats to predict potential human risks.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants widely used by the population contain significant concentrations of biologically active compounds and, although they have proven pharmacological properties, can cause DNA damage and develop fatal diseases. AIM OF THE STUDY:The present study aimed to evaluate the genotoxic, cytotoxic potential and clastogenic effects of the aqueous extract from Mangifera indica leaves (EAMI) on rats submitted to experimental genotoxicity models and through the SMART test performed in Drosophila melanogaster. MATERIAL AND METHODS:The comet assay and the micronucleus test were performed on peripheral and bone marrow blood, respectively, of Wistar rats, orally treated with EAMI at doses of 125, 250, 500 and 1000 mg/kg/bw for 28 days. In the SMART test, the standard cross between three mutant D. melanogaster strains was used. Larvae were treated with EAMI at different concentrations, and the wings of adult flies were evaluated for the presence/frequency of mutant spots and compared to the negative control group. RESULTS:Phytochemical analysis of EAMI indicated high levels of flavonoids. The tests performed in rats showed that EAMI did not present significant genotoxic or clastogenic effects. The results showed a critical dose-dependent cytoprotective effect exerted by EAMI. This result was attributed to the high content of polyphenols and flavonoids. The biotransformation metabolites of EAMI did not present genotoxic activity, as demonstrated by the SMART test. CONCLUSIONS:These results are relevant since they provide safety information about a plant species of great therapeutic, economical, nutritious and ethnopharmacological value for the population.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Villas Boas GR,Rodrigues Lemos JM,de Oliveira MW,Dos Santos RC,Stefanello da Silveira AP,Bacha FB,Aguero Ito CN,Cornelius EB,Lima FB,Sachilarid Rodrigues AM,Costa NB,Bittencourt FF,Freitas de Lima F,Paes MM,Gubert P,Oesterr

doi

10.1016/j.jep.2019.112086

subject

Has Abstract

pub_date

2019-10-28 00:00:00

pages

112086

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(19)31327-3

journal_volume

243

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Effect and putative mechanism of action of ginseng on the formation of glycated hemoglobin in vitro.

    abstract：:As a non-enzymatic, covalent binding between glucose and protein, glycation is a well-known cause of various forms of diabetic complications. This study was undertaken to determine the effect and mechanism of action of ginseng on the formation of glycated protein. A solution containing hemoglobin and glucose was incub...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.12.008

    authors： Bae JW,Lee MH

    更新日期：2004-03-01 00:00:00

  • Medicinal smokes.

    abstract：:All through time, humans have used smoke of medicinal plants to cure illness. To the best of our knowledge, the ethnopharmacological aspects of natural products' smoke for therapy and health care have not been studied. Mono- and multi-ingredient herbal and non-herbal remedies administered as smoke from 50 countries ac...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2006.09.005

    authors： Mohagheghzadeh A,Faridi P,Shams-Ardakani M,Ghasemi Y

    更新日期：2006-11-24 00:00:00

  • Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Geum urbanum L. (wood avens) root infusions and decoctions have been used externally for reducing the bleeding and inflammation of gums (gingivitis), and mucous membranes. AIM OF THE STUDY:Taking into account that primed and hyperactivated neutrophils are an important factor in the trans...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.04.030

    authors： Granica S,Kłębowska A,Kosiński M,Piwowarski JP,Dudek MK,Kaźmierski S,Kiss AK

    更新日期：2016-07-21 00:00:00

  • Toxicological and anti-inflammatory profile of Synadenium grantii Hook. f. in mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Synadenium grantii Hook. f., popularly known as "janaúba" or "leiterinha", is used in the folk medicine to treat gastric disorders, some types of neoplasias and inflammatory diseases. AIM OF THE STUDY:The aim of this study was to show the anti-inflammatory activity of the methanol extrac...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113487

    authors： de Souza JA,Patel YBK,Grockoski HA,Nunes R,Ramos SA,Pastor MVD,Stoeberl LC,Campos A,Cechinel Filho V,Santin JR,Quintão NLM

    更新日期：2021-03-01 00:00:00

  • Rhizoma Amorphophalli inhibits TNBC cell proliferation, migration, invasion and metastasis through the PI3K/Akt/mTOR pathway.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Triple-negative breast cancer (TNBC) often presents with a high histological grade and high malignancy, which greatly contribute to patient morbidity and mortality. Rhizoma Amorphophalli exhibits many biological and pharmacological activities, but its potential as a therapeutic agent for ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.09.033

    authors： Wu C,Qiu S,Liu P,Ge Y,Gao X

    更新日期：2018-01-30 00:00:00

  • Antibacterial activity of Brazilian propolis and fractions against oral anaerobic bacteria.

    abstract：:Propolis collected from a cerrado area in Minas Gerais State, Brazil, was subjected to chromatography on silica gel column and to partition between immiscible solvents. Propolis aqueous-ethanolic extract and fractions obtained were tested for inhibitory activity against periodontitis-causing bacteria. All of the assay...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00003-x

    authors： Santos FA,Bastos EM,Uzeda M,Carvalho MA,Farias LM,Moreira ES,Braga FC

    更新日期：2002-04-01 00:00:00

  • Curcumin/turmeric solubilized in sodium hydroxide inhibits HNE protein modification--an in vitro study.

    abstract：:Free radical mediated lipid peroxidation has been implicated in multiple diseases. A major oxidation by-product of this deleterious process is 4-hydroxy-2-nonenal (HNE). HNE is cytotoxic, mutagenic and genotoxic and is involved in disease pathogenesis. Curcumin, a non-steroidal anti-inflammatory agent (occurring as th...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.09.034

    authors： Kurien BT,Scofield RH

    更新日期：2007-03-21 00:00:00

  • Metabolomics coupled with SystemsDock reveal the protective effect and the potential active components of Naozhenning granule against traumatic brain injury.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Naozhenning granule (NZN), a widely traditional Chinese medicine (TCM) prescription with a long history of clinical, which is mainly used in the treatment of concussion, cerebral post-traumatic syndrome, consists of Di Huang (Radix of Rehmannia glutinosa (Gaertn.) DC.), Dang Gui (Radix of...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112247

    authors： Cao J,Duan Y,Liu Y,Liu H,Wei C,Wang J,Qin X,Wang X,Li Z

    更新日期：2020-01-10 00:00:00

  • Cardioprotective effects of rhamnetin in H9c2 cardiomyoblast cells under H₂O₂-induced apoptosis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Many studies have emphasized that flavonoids, found in various fruits, vegetables, and seeds, as well as tea and red wine, have potential health-promoting and disease-preventing effects. Rhamnetin is a flavonoid that exhibits antioxidant capabilities. However, little is known about its ef...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.02.019

    authors： Park ES,Kang JC,Jang YC,Park JS,Jang SY,Kim DE,Kim B,Shin HS

    更新日期：2014-05-14 00:00:00

  • Ethnobotanical survey of medicinal plants used in the treatment of malaria in Ogbomoso, Southwest Nigeria.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Malaria infection is the second largest killer disease after HIV in Nigeria. Failure of the orthodox medications due to drug adulteration, high cost of procurement of antimalarial drugs and inconvenience experienced in the use of high dosage of the new antimalarial drug combination therap...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.07.038

    authors： Olorunnisola OS,Adetutu A,Balogun EA,Afolayan AJ

    更新日期：2013-10-28 00:00:00

  • Triterpenoids from the genus Gynostemma: Chemistry and pharmacological activities.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:G. pentaphyllum, also known as Jiao-Gu-Lan, has been used traditionally as folk remedies for many diseases, including diabetes mellitus, metabolic syndrome, aging, and neurodegenerative diseases in China and some countries in East and Southeast Asia. It is considered as an "immortality he...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2020.113574

    authors： Nguyen NH,Ha TKQ,Yang JL,Pham HTT,Oh WK

    更新日期：2021-03-25 00:00:00

  • Evaluation of the mutagenic and antimutagenic effects of South African plants.

    abstract：:Dichloromethane and 90% methanol extracts of 42 South African plants were screened for mutagenicity and antimutagenicity using the Salmonella/microsome mutagenicity assay (Ames) against Salmonella typhimurium TA98 and TA100 bacterial strains in the presence and absence of metabolic activator S9. The methanol extracts ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.11.030

    authors： Reid KA,Maes J,Maes A,van Staden J,De Kimpe N,Mulholland DA,Verschaeve L

    更新日期：2006-06-15 00:00:00

  • Plants popularly used for loosing weight purposes in Porto Alegre, South Brazil.

    abstract：:In this study, 14 herbalists (herb sellers) were interviewed about popular use of plants with weight loss purpose in Porto Alegre, a South Brazil city. For all identified species, scientific data were reviewed aiming to establish a correlation between popular use and biological properties. Seventy-eight samples were r...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.07.003

    authors： Dickel ML,Rates SM,Ritter MR

    更新日期：2007-01-03 00:00:00

  • The research progresses and future prospects of Tetrastigma hemsleyanum Diels et Gilg: A valuable Chinese herbal medicine.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Tetrastigma hemsleyanum Diels et Gilg, known as Sanyeqing in China, was an extensively used folk Chinese herbal medicine. This plant had been validated to be highly effective for treating high fever, pneumonia, hepatitis, gastritis, cervicitis, lymphatic tuberculosis, septicemia, and vira...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2021.113836

    authors： Hu W,Zheng Y,Xia P,Liang Z

    更新日期：2021-01-16 00:00:00

  • Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic rats.

    abstract：:Aqueous, ethanolic and hexane fractions of Momordica cymbalaria fruits were prepared and given individually at different doses to different batches of rats (both normal and alloxan diabetic rats) after an overnight fast. The blood glucose levels were measured at 0, 1, 3, 5 and 7 h after the treatment. The aqueous extr...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00324-5

    authors： Rao BK,Kesavulu MM,Apparao C

    更新日期：2001-11-01 00:00:00

  • Antitumour activity of Bauhinia variegata on Dalton's ascitic lymphoma.

    abstract：:The antitumour activity of the ethanol extract of Bauhinia variegata (EBV) has been evaluated against Dalton's ascitic lymphoma (DAL) in Swiss albino mice. A significant enhancement of mean survival time of EBV-treated tumour bearing mice was found with respect to control group. EBV treatment was found to enhance peri...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00264-2

    authors： Rajkapoor B,Jayakar B,Murugesh N

    更新日期：2003-11-01 00:00:00

  • Bioassay-guided fractionation and identification of wound healing active compound from Pistacia vera L. hull extract.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Pistachio hull has traditionally been used to treat peptic ulcer, hemorrhoids, oral and cutaneous wounds. AIM OF THE STUDY:On the basis of its traditional uses and previous pharmacological reports, a bioassay guided fractionation procedures on pistachio (Pistacia vera L.) hulls was perfo...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112335

    authors： Sarkhail P,Navidpour L,Rahimifard M,Hosseini NM,Souri E

    更新日期：2020-02-10 00:00:00

  • Paeonia lactiflora extract suppresses cisplatin-induced muscle wasting via downregulation of muscle-specific ubiquitin E3 ligases, NF-κB signaling, and cytokine levels.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The dried root of Paeonia lactiflora Pall. (Radix Paeoniae) has been traditionally used to treat various inflammatory diseases in many Asian countries. AIM OF THE STUDY:Cisplatin is a broad-spectrum anticancer drug used in diverse types of cancer. However, muscle wasting is a common side...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113403

    authors： Jang J,Lee H,Song J,Bae T,Park M,Kwon YV,Lee D,Yoon Y

    更新日期：2021-02-10 00:00:00

  • Reverse ethnopharmacology and drug discovery.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ethnopharmacological investigations of traditional medicines have made significant contributions to plant-derived drugs, as well as the advancement of pharmacology. Drug discovery from medicinal flora is more complex than generally acknowledged because plants are applied for different the...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.12.044

    authors： Leonti M,Stafford GI,Cero MD,Cabras S,Castellanos ME,Casu L,Weckerle CS

    更新日期：2017-02-23 00:00:00

  • Liuwei Dihuang soft capsules inhibits the phenotypic conversion of VSMC to prevent the menopausal atherosclerosis by up-regulating the expression of myocardin.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Liuwei Dihuang (LWDH) is a classic prescription that has been used as a traditional medicinal formula for more than 1000 years in China. In clinical, LWDF is used for treating functional decline associated with senile disease and menopausal syndrome. Studies have demonstrated that LWDH co...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112207

    authors： Meng Q,Yu X,Chen Q,Wu X,Kong X,Wang S,Cai D,Cheng P,Li Y,Bian H

    更新日期：2020-01-10 00:00:00

  • The food plant Silybum marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and clinical evidence.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Silybum marianum (L.) Gaertn. or Milk thistle is a medicinal plant native to Northern Africa, Southern Europe, Southern Russia and Anatolia. It also grows in South Australia, North and South America. In traditional knowledge, people have used S. marianum for liver disorders such as hepati...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2020.113303

    authors： Marmouzi I,Bouyahya A,Ezzat SM,El Jemli M,Kharbach M

    更新日期：2021-01-30 00:00:00

  • Evaluation of the protective potential of Artemisia maritima extract on acetaminophen- and CCl4-induced liver damage.

    abstract：:The hepatoprotective activity of the aqueous-methanolic extract of Artemisia maritima was investigated against acetaminophen (paracetamol, 4-hydroxy acetanilide)- and carbon tetrachloride (CCl4)-induced hepatic damage. Acetaminophen produced 100% mortality at the dose of 1 g/kg in mice, while pretreatment of animals w...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(95)01252-9

    authors： Janbaz KH,Gilani AH

    更新日期：1995-06-23 00:00:00

  • Ameliorative potential of standardized fruit extract of Pterodon pubescens Benth on neuropathic pain in mice: Evidence for the mechanisms of action.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The medicinal plant Pterodon pubescens Benth has been traditionally used for a long time to treat rheumatic diseases due to its anti-inflammatory and analgesic activities. The present study aims to evaluate the antinociceptive effect of ethanolic extract from P. pubescens fruits (EEPp) in...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.09.005

    authors： Nucci-Martins C,Martins DF,Nascimento LF,Venzke D,Oliveira AS,Frederico MJ,Silva FR,Brighente IM,Pizzolatti MG,Santos AR

    更新日期：2015-12-04 00:00:00

  • Anxiolytic effects of the aqueous extract of Uncaria rhynchophylla.

    abstract：:The purpose of this study was to characterize the putative anxiolytic-like effects of the aqueous extract of hooks with stem of Uncaria rhynchophylla using the elevated plus maze (EPM) and the hole-board apparatus in rats and mice. Control rats were treated with an equal volume of saline, and positive control rats wit...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.05.019

    authors： Jung JW,Ahn NY,Oh HR,Lee BK,Lee KJ,Kim SY,Cheong JH,Ryu JH

    更新日期：2006-11-24 00:00:00

  • Effects of dichloromethane and butanol fractions of Gochnatia polymorpha floccosa in maternal reproductive outcome, embryo-fetal development and DNA integrity in mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Gochnatia polymorpha ssp. floccosa (Asteraceae) also known as ''Cambará'' is used as medicinal plant in Brazil to treat infections and inflammation. Previous studies showed that its ethanolic extract could be bioprospecting of a new anti-inflammatory phytotherapy for use during pregnancy....

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.02.042

    authors： Pessatto LR,Auharek SA,Gonçalves CA,de David N,Monreal AC,Kassuya CA,Antoniolli-Silva AC,Stefanello MÉ,Oliveira RJ

    更新日期：2017-03-22 00:00:00

  • Ethyl acetate fraction from Nymphaea hybrida Peck modulates inflammatory responses in LPS-stimulated RAW 264.7 cells and acute inflammation murine models.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Nymphaea hybrida Peck is used as a traditional medicinal herb for treating pain and inflammatory diseases, and known for its ornamental value and as a hot drink. However, the effects of N. hybrida polar fractions on lipopolysaccharide (LPS)-induced in vitro inflammation model and acute in...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113698

    authors： Zhang Z,Jiang S,Tian H,Zeng Y,He K,Lin L,Yu F

    更新日期：2021-04-06 00:00:00

  • Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus.

    abstract：:A crude extract prepared from Scutellaria barbata D. Don (Lamiaceae) was analyzed in the effort to discover antibacterial compounds against high-level strains of methicillin-resistant Staphylococcus aureus (MRSA). Apigenin and luteolin were isolated from the plant as active constituents against the bacteria. These fla...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00265-8

    authors： Sato Y,Suzaki S,Nishikawa T,Kihara M,Shibata H,Higuti T

    更新日期：2000-10-01 00:00:00

  • Regulation effects on abnormal glucose and lipid metabolism of TZQ-F, a new kind of Traditional Chinese Medicine.

    abstract：AIM OF THE STUDY:Based on the recipe of the traditional anti-diabetic formula TZQ, we developed TZQ-F, a new formula including 8 fractions isolated from Red Paeony root, Mulberry leaf, Lotus leaf, Danshen root and Hawthorn leaf with a good quality assurance. The study was aimed at fraction preparation and effects of th...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.01.044

    authors： Tao W,Deqin Z,Yuhong L,Hong L,Zhanbiao L,Chunfeng Z,Limin H,Xiumei G

    更新日期：2010-04-21 00:00:00

  • Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Antimicrobial drug resistance is a growing threat to global public health. Historical records and herbal texts relating to traditional Celtic medicine indicate an extensive pharmacopeia of plants for treating infections likely caused by microbes. However, a major barrier for successful in...

    journal_title：Journal of ethnopharmacology

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.jep.2017.03.039

    authors： Wagner CS,De Gezelle J,Robertson M,Robertson K,Wilson M,Komarnytsky S

    更新日期：2017-05-05 00:00:00

  • Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice.

    abstract：:Melissa officinalis L. (Labiatae), Morus alba L. (Moraceae), and Artemisia capillaris Thunb. (Compositae) are suggested to be involved in the regulation of hyperlipidemia. We hypothesized that Ob-X, a mixture of three herbs, Morus alba, Melissa officinalis and Artemisia capillaris [corrected] improves lipid metabolism...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.09.029

    authors： Lee J,Chae K,Ha J,Park BY,Lee HS,Jeong S,Kim MY,Yoon M

    更新日期：2008-01-17 00:00:00