Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE:QingYan Formula has been traditionally used to tonify kidney and benefit essence, and QingYan Formula 70% ethanol extracts (QYFE) showed estrogen-like effect on reproductive system in our previous studies. However, there were no reports of QYFE on bone. AIM OF THE STUDY:This study offered preliminary insight of QYFE into the pharmacodynamics and mechanism of anti-bone osteoporosis in ovariectomized rats. MATERIALS AND METHODS:OVX rats were orally administrated QYFE or estradiol valerate (EV) for 12 weeks. We investigated the pharmacodynamic effects of QYFE on anti-bone loss in OVX rats, and also investigated the role of QYFE in promoting osteogenesis and inhibiting osteoclast differentiation. RESULTS:QYFE administration significantly reduced the degree of high bone turnover, dose-dependently repaired the damaged microstructure of trabecular and cortical bone by Hematoxylin-Eosin (HE) staining and micro-computed tomography (micro-CT), and reduced the number of femur osteoclasts by TRAP staining. QYFE enhanced the proliferation and activity of alkaline phosphatase (ALP), the phosphorylation levels of extracellular regulated kinase (ERK) and Akt in MG-63 cells, which was inhibited by ICI 182 780. Moreover, in RAW264.7 cells, QYFE inhibited osteoclasts differentiation, reduced the number of osteoclasts, decreased the activity of TRAP enzyme during formation, down-regulated the protein expression of p-ERK inhibited by ICI 182 780 and p-Akt not inhibited by ICI 182 780. CONCLUSION:This experiment demonstrated that QYFE had a definite anti-bone loss effect and had potential effect on postmenopausal osteoporosis. The molecular mechanism was related to the activation of estrogen receptor (ER)-dependent mitogen-activated protein kinase kinase (MEK)/ERK and phosphoinositide 3-kinase (PI3K)/Akt signal pathways in osteoblast, down-regulation protein expressions of ER-dependent p-ERK and ER-independent p-Akt in osteoclast.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Zhao Y,Xu Y,Zheng H,Lin Ndoi
10.1016/j.jep.2020.113644subject
Has Abstractpub_date
2021-03-25 00:00:00pages
113644eissn
0378-8741issn
1872-7573pii
S0378-8741(20)33532-7journal_volume
268pub_type
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
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journal_title:Journal of ethnopharmacology
pub_type: 历史文章,杂志文章
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abstract::Powdered Solanum lycocarpum fruit is commonly used to treat diabetes, but apparently no studies have been conducted to evaluate potential adverse side effects. In the present paper the toxic effect of S. lycocarpum was evaluated in adult male Wistar rats and Swiss mice. The administration of an aqueous extract prepare...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:1999-03-01 00:00:00
abstract::The anticonvulsant effect of the volatile oil extracted from the fresh fruits of Tetrapleura tetraptera was investigated in mice. The results obtained show that the fresh oil given intraperitoneally offers some protection against leptazol-induced convulsions. A dose of 0.4 ml of the oil per mouse protected 78% of the ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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abstract:ETHNOPHARMACOLOGICAL RELEVANCE:A wide variety of traditional herbal remedies have been used throughout history for the treatment of symptoms related to acute respiratory infections (ARIs). AIM OF THE REVIEW:The present work provides a timely overview of natural products affecting the most common pathogens involved in ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
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更新日期:2020-02-10 00:00:00