Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE:A wide variety of traditional herbal remedies have been used throughout history for the treatment of symptoms related to acute respiratory infections (ARIs). AIM OF THE REVIEW:The present work provides a timely overview of natural products affecting the most common pathogens involved in ARIs, in particular influenza viruses and rhinoviruses as well as bacteria involved in co-infections, their molecular targets, their role in drug discovery, and the current portfolio of available naturally derived anti-ARI drugs. MATERIALS AND METHODS:Literature of the last ten years was evaluated for natural products active against influenza viruses and rhinoviruses. The collected bioactive agents were further investigated for reported activities against ARI-relevant bacteria, and analysed for the chemical space they cover in relation to currently known natural products and approved drugs. RESULTS:An overview of (i) natural compounds active in target-based and/or phenotypic assays relevant to ARIs, (ii) extracts, and (iii) in vivo data are provided, offering not only a starting point for further in-depth phytochemical and antimicrobial studies, but also revealing insights into the most relevant anti-ARI scaffolds and compound classes. Investigations of the chemical space of bioactive natural products based on principal component analysis show that many of these compounds are drug-like. However, some bioactive natural products are substantially larger and have more polar groups than most approved drugs. A workflow with various strategies for the discovery of novel antiviral agents is suggested, thereby evaluating the merit of in silico techniques, the use of complementary assays, and the relevance of ethnopharmacological knowledge on the exploration of the therapeutic potential of natural products. CONCLUSIONS:The longstanding ethnopharmacological tradition of natural remedies against ARIs highlights their therapeutic impact and remains a highly valuable selection criterion for natural materials to be investigated in the search for novel anti-ARI acting concepts. We observe a tendency towards assaying for broad-spectrum antivirals and antibacterials mainly discovered in interdisciplinary academic settings, and ascertain a clear demand for more translational studies to strengthen efforts for the development of effective and safe therapeutic agents for patients suffering from ARIs.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Langeder J,Grienke U,Chen Y,Kirchmair J,Schmidtke M,Rollinger JMdoi
10.1016/j.jep.2019.112298subject
Has Abstractpub_date
2020-02-10 00:00:00pages
112298eissn
0378-8741issn
1872-7573pii
S0378-8741(19)32520-6journal_volume
248pub_type
杂志文章,评审abstract:ETHNOBOTANICAL RELEVANCE:From ancient times, the applied use of herbs has been common among indigenous people throughout the world. The present survey is a regional ethnobotanical study of Baluchi tribes living in the Mt. Taftan area, Sistan and Baluchistan Province, southeastern Iran. The aim of this study was to docu...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2018.02.017
更新日期:2018-05-10 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Spatholobus suberectus Dunn is a traditional Chinese medicine (TCM) that can activate blood, dispel stasis, inhibit platelet aggregation, and stimulate hematopoiesis, and thereby treat anemia and diseases related to blood stasis syndrome (BSS). However, its hematopoiesis-stimulating activ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2019.111938
更新日期:2019-08-10 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Danqi Pill, composed of the root of Salvia miltiorrhiza Bunge and the root of Panax notoginseng, is effective in the clinical treatment of myocardial ischemia in coronary heart diseases. A number of studies have shown that autophagy plays an essential role in cardiac function and energy m...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2020.113404
更新日期:2021-02-10 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Xiao-Xu-Ming decoction (XXMD) has long been employed clinically to treat stroke in traditional Chinese Medicine. AIM OF THE STUDY:To investigate the neuroprotective effects of XXMD in vivo and in vitro stroke models and determine involved mechanisms. MATERIALS AND METHODS:Two models (fo...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2009.09.054
更新日期:2010-01-08 00:00:00
abstract::Antitumor and immunomodulatory activities of an aqueous extract (GF100) of Acanthopanax senticosus were examined. In experimental lung metastasis of colon26-M3.1 carcinoma cells, intravenous (i.v.) administration of GF100 2 days before tumor inoculation significantly inhibited lung metastasis in a dose-dependent manne...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2004.03.052
更新日期:2004-08-01 00:00:00
abstract::Anti-inflammatory and analgesic activities as well as the median lethal dose (LD50) of water-ethanolic extract (PHE) of the aerial parts of Pothomorphe umbellata were evaluated in animal models. The ED(50) (oral) for the inhibition of carrageenan-induced rat paw edema assay was determined to be 550 mg/kg, while the LD...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2005.02.023
更新日期:2005-06-03 00:00:00
abstract:AIM OF THE STUDY:We present and discuss a particular group of plants used by a diversity of healers in the initiation process and apprenticeship of traditional medicine, as practiced by Amazonian societies in East-Central Peru. Often, these plants are locally called plantas con madre (plants with a mother), and are tho...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2011.01.042
更新日期:2011-04-12 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Xiaoxuming decoction (XXMD) is a well-known traditional Chinese herbal prescription in treatment of patients with stroke. The objective of this study is to assess the efficacy and safety of XXMD for acute ischemic stroke. MATERIALS AND METHODS:A systematic literature search was conducted...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jep.2013.04.002
更新日期:2013-06-21 00:00:00
abstract::To investigate the effect of traditional herbal formulae (Zhong Yao) against experimental hypercholesterolemia, we assayed serum lipoprotein levels and hepatic function in rats administered herbal formulae under cholesterol rich diet. Two kinds of herbal formulae; prescription 1 (Bupleurum chinense and other 9 kinds o...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2004.05.009
更新日期:2004-10-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The role of Azadirachta indica (neem) against Chagas disease and its antibiotic and antidiabetic action have been demonstrated in non-pregnant animals. However, the effects of neem on lipid metabolism and oxidative stress during pregnancy remain to be investigated. The objective of this s...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2012.07.023
更新日期:2012-10-11 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The root extract of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) is traditionally used in the management of pain and fever. However, little scientific data exists in literature to support its use. AIM OF STUDY:The present study evaluated the anti-nociceptive and antipyretic ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2017.02.007
更新日期:2017-03-06 00:00:00
abstract::Aconitum species have been used in China as an essential drug in Traditional Chinese Medicine (TCM) for 2000 years. Reviewing the clinical application of Aconitum, their pharmacological effects, toxicity and detoxifying measures, herb-herb interactions, clinical taboos, famous herbal formulas, traditional and current ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2009.07.031
更新日期:2009-10-29 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The lack of ethnoveterinary surveys in Brazil, especially in the Amazon region, results in losses in the veterinary phytopharmacology field and in scientific documentation of the cultural traditions of plant use in the treatment of animal diseases. AIM OF THE STUDY:To catalog, analyze an...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2012.09.018
更新日期:2012-11-21 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Malaria infection is the second largest killer disease after HIV in Nigeria. Failure of the orthodox medications due to drug adulteration, high cost of procurement of antimalarial drugs and inconvenience experienced in the use of high dosage of the new antimalarial drug combination therap...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2013.07.038
更新日期:2013-10-28 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Salvia miltiorrhiza, a perennial plant in the genus Salvia and popularly known as "Danshen", is highly valued for its roots in traditional Chinese medicines (TCMs). It has widely used for the treatment of cerebrovascular and cardiovascular diseases in China. Recently, the cerebral protect...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2014.12.048
更新日期:2015-03-13 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The search for natural agents that minimize obesity-associated disorders is receiving special attention. Parkinsonia aculeata L. (Caesalpineaceae) has long been used in Brazil as a hypoglycaemic herbal medicine, without any scientific basis. AIMS OF THE STUDY:In this context, we aimed to...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2016.02.048
更新日期:2016-05-13 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Gochnatia polymorpha ssp. floccosa (Asteraceae) also known as ''Cambará'' is used as medicinal plant in Brazil to treat infections and inflammation. Previous studies showed that its ethanolic extract could be bioprospecting of a new anti-inflammatory phytotherapy for use during pregnancy....
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2017.02.042
更新日期:2017-03-22 00:00:00
abstract::Lithospermi radix (LR, root of Lithospermum erythrorhizon Siebold. et Zuccarinii) has been used to treat various conditions, such as septic shock, eczema and burns. In this study, the effect of LR on lipopolysaccharide (LPS) and recombinant interferon-gamma (rIFN-gamma)-induced production of nitric oxide (NO) and tumo...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2005.06.028
更新日期:2005-12-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Bei Qi Wu Jia (BQWJ), a modern preparation of a traditional Chinese medicinal formula, is a combination of Radix Astragali and Acanthopanacis Senticosi. Although BQWJ has been used to treat insomnia, fatigue, and loss of appetite, toxicological safety studies are rare in the literature. ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2019.112324
更新日期:2020-02-10 00:00:00
abstract::The study was conducted around Debre Libanos monastery from October 2005 to June 2006. A total of 250 villagers, 13 monks and 3 nuns were interviewed using semistructured questionnaire on the knowledge and use of medicinal plants. The informant consensus factor (ICF) and the fidelity level (FL) of the species were det...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2006.11.019
更新日期:2007-05-04 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Propolis has long been used as a popular folk medicine due to its wide spectrum of alleged biological and pharmaceutical properties. In Chile, propolis is widely used by folklore medicine as an anti-inflammatory agent; however, this property has not been demonstrated by scientific methods...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2015.03.050
更新日期:2015-06-20 00:00:00
abstract:AIM OF THE STUDY:The tubers of Euphorbia fusiformis Buch.-Ham.ex D.Don (Euphorbiaceae) are traditionally used in India by the Malayali tribes of Chitteri hills, Eastern Ghats, Tamil Nadu to treat liver disorders. The objective of the present study was to assess the hepatoprotective potential and biosafety of Euphorbia ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2009.10.012
更新日期:2010-02-03 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Postmenopausal osteoporosis is the most common bone disease worldwide. Information concerning the effects of herbal medicines on mesenchymal cell osteogenesis and senescence remains lacking. AIM OF THIS STUDY:This study was designed to investigate the effects of Du-Huo-Ji-Sheng-Tang (DHJ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2016.12.011
更新日期:2017-02-23 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Euphorbia tirucalli L. is widely used by Brazilian folk medicine, mainly for its anticancer activity. However, its commercialization was banned by The Brazilian National Sanitary Surveillance Agency (ANVISA) due to the presence of some compounds considered toxic, such as the diterpene est...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2019.03.041
更新日期:2019-06-12 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Tetrastigma hemsleyanum Diels et Gilg, known as Sanyeqing in China, was an extensively used folk Chinese herbal medicine. This plant had been validated to be highly effective for treating high fever, pneumonia, hepatitis, gastritis, cervicitis, lymphatic tuberculosis, septicemia, and vira...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2021.113836
更新日期:2021-01-16 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Ibogaine is a naturally occurring alkaloid with psychotropic and metabotropic effects, derived from the bark of the root of the West African Tabernanthe iboga plant. The tribes of Kongo basin have been using iboga as a stimulant, for medicinal purposes, and in rite of passage ceremonies, ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2015.01.037
更新日期:2015-04-22 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Rhodiola algida, an herb ingredient used in Chinese medicine, has been clinically proven to be effective in enhancing human immune responses. AIM OF STUDY:This study attempted to identify the potential immunomodulatory effect of Rhodiola algida extract in human immune system in vitro, an...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2009.03.009
更新日期:2009-06-22 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:An investigation of plants was undertaken through interviews and literature surveys on plants used to treat malaria or cancer or microbial diseases in Iran. AIM OF STUDY:In vitro and in vivo antiplasmodial tests were carried out on selected plants traditionally used in Iran. MATERIALS A...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2008.10.041
更新日期:2009-01-30 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Artemisia asiatica Nakai is a traditional herbal plant that has long been used in anti-inflammatory, anti-infective and skin protective remedies. AIM OF THE STUDY:In this study, traditionally known skin-protective activity of Artemisia asiatica Nakai was examined with its ethanol extract...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2018.03.037
更新日期:2018-06-28 00:00:00
abstract::Strychnos henningsii Gilg is used in African traditional medicine for the treatment of various ailments, including rheumatism, gastrointestinal complaints and snake bites. Different preliminary pharmacological experiments are described. The results show that some of the reported folk medicinal applications of S. henni...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/0378-8741(91)90045-f
更新日期:1991-09-01 00:00:00