Abstract：
:Antitumor and immunomodulatory activities of an aqueous extract (GF100) of Acanthopanax senticosus were examined. In experimental lung metastasis of colon26-M3.1 carcinoma cells, intravenous (i.v.) administration of GF100 2 days before tumor inoculation significantly inhibited lung metastasis in a dose-dependent manner. The i.v. administration of GF100 also exhibited the therapeutic effect on tumor metastasis of colon26-M3.1 cells, when it was injected 1 day after tumor inoculation. In an in vitro cytotoxicity analysis, GF100 at the concentration up to 1000 microg/ml did not affect the growth of colon26-M3.1 cells. In contrast, GF100 enhanced the responsiveness to a mitogen, concanavalin A (ConA), of splenocytes in a dose-dependent manner. Peritoneal macrophage stimulated with GF100 produced various cytokines such as IL-1beta, TNF-alpha, IL-12 and IFN-gamma in an in vitro experiment. The macrophages obtained from the mice which were injected with GF100 (500 microg) 3 days before the assay showed significantly higher tumoricidal activity against tumor cells than that of the untreated macrophages. In addition, the i.v. administration of GF100 significantly augmented NK cytotoxicity to Yac-1 cells. The depletion of NK cells by injection of rabbit anti-asialo GM1 serum completely abolished the inhibitory effect of GF100 on lung metastasis of colon26-M3.1 cells. These data suggest that GF100 has antitumor activity to inhibit tumor metastasis prophylactically as well as therapeutically, and its antitumor effect is associated with activation of macrophages and NK cells.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Yoon TJ,Yoo YC,Lee SW,Shin KS,Choi WH,Hwang SH,Ha ES,Jo SK,Kim SH,Park WMdoi
10.1016/j.jep.2004.03.052keywords:
subject
Has Abstractpub_date
2004-08-01 00:00:00pages
247-53issue
2-3eissn
0378-8741issn
1872-7573pii
S0378874104001357journal_volume
93pub_type
杂志文章abstract：AIM OF THE STUDY:This study was undertaken to provide a pharmacological basis for traditional use of Acorus calamus in airways disorders. MATERIALS AND METHODS:Isolated guinea-pig trachea and atria were suspended in organ baths bubbled with carbogen and mechanisms were found using different parameters. RESULTS:In iso...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.07.024
更新日期：2010-09-15 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Hericium is a genus of mushrooms (fungus) in the Hericiaceae family. Hericium erinaceus (HE) has been used for the treatment of digestive diseases for over 2000 years in China. HE possesses many beneficial functions such as anticancer, antiulcer, antiinflammation and antimicrobial effects...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2014.03.003
更新日期：2014-04-28 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Bojungikki-tang is a traditional herbal medicine used to boost immunity and reduce fatigue. However, there is not enough scientific evidence about its toxicological safety profile to support its continued clinical application. AIM OF THE STUDY:The objective of this study was to investiga...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112551
更新日期：2020-04-24 00:00:00
abstract：:We studied the effect of Acanthopanax senticosus stem (ACPS) on mast cell-dependent anaphylaxis. ACPS inhibited compound 48/80-induced systemic anaphylaxis at a dose of 1.0 g/kg by 50%. ACPS also inhibited passive cutaneous anaphylaxis reaction and histamine release from mast cells in a dose-dependent manner, respecti...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(01)00403-2
更新日期：2002-03-01 00:00:00
abstract：:The effects of extracts from various oriental medicinal herbs on mast cell-mediated allergic reaction were investigated. Among them, Chrysanthemi sibirici herba ethanol extract exerted the potent inhibitory activity on antigen-induced degranulation in RBL-2H3 mast cells. Chrysanthemi sibirici herba dose-dependently in...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2004.08.023
更新日期：2004-12-01 00:00:00
abstract：AIMS OF THE STUDY:Cardiospermum halicacabum (CH) has been used in Chinese medicine for a long time. However, its fingerprint chromatogram, antioxidant, anti-inflammatory effects and mechanism are still needed to be explored. Therefore, the aims of this study investigated the antioxidant and anti-inflammatory effects of...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.11.005
更新日期：2011-01-27 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In Brazil, latex of Himatanthus drasticus is used to treat inflammation, wound healing and cancer. The present study evaluated the antitumoral potential of H. drasticus latex (HdCL) in Sarcoma 180-bearing mice (S180). MATERIALS AND METHODS:HdCL was obtained in Crato-CE, Brazil. Qualitati...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.09.043
更新日期：2018-06-28 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Operculina macrocarpa is an ornamental climbing plant of the Northeastern Brazil extensively used in traditional medicine as depurative of the blood and for the treatment of thrombosis. To investigate the antiplatelet and anticoagulant potential of Operculina macrocarpa and to determine t...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2013.10.008
更新日期：2014-01-01 00:00:00
abstract：:Acyl-coenzyme A: cholesterol acyltransferase (ACAT) esterifies free cholesterol in the liver and the intestine. It has relations with production of lipoproteins and accumulation of cholesteryl esters of the atheroma. Therefore, ACAT inhibitors may act as antihypercholesterolemic and antiatherosclerotic agents. One iso...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2006.10.012
更新日期：2007-04-04 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In Togo, many persons still rely on plants for healing, however very little is known about the medicinal practices of the indigenous people. The present study aimed to document the medicinal plant utilization for the management of liver diseases in the Maritime region of the country. MET...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2015.12.051
更新日期：2016-04-02 00:00:00
abstract：INTRODUCTION:Mirabilis jalapa Linn is a well-studied plant. The indigenous people of Mexico use Mirabilis jalapa to cure many infirmities including dysentery, diarrhea, muscular pain and abdominal colic. In the present investigation, we have further characterized some pharmacological properties of an extract of Mirabil...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2007.11.004
更新日期：2008-02-28 00:00:00
abstract：AIM OF THE STUDY:Withania aristata is an endemic plant used traditionally in Canary Islands as a diuretic. In this paper, we report on this pharmacological activity in several extracts of the dry vegetal material collected and the identification and diuretic activity of two withanolides, one of them previously not repo...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2008.12.014
更新日期：2009-06-22 00:00:00
abstract：AIM OF THE STUDY:To investigate the effect of tashinone IIA (TA) on intimal hyperplasia in a rat model of carotid artery balloon injury and on the proliferation of cultured vascular smooth muscle cells (VSMCs) induced by fetal bovine serum (FBS) and its underlying mechanisms. MATERIALS AND METHODS:Carotid artery injur...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.03.021
更新日期：2010-05-27 00:00:00
abstract：AIM OF THE STUDY:In the present study, we investigated the effects of Kangen-karyu, a traditional Chinese prescription comprising six herbs, on diabetes. MATERIALS AND METHODS:Kangen-karyu extract (50, 100, or 200mg/kg body weight) was administered to streptozotocin (STZ)-induced diabetic rats and serum and hepatic bi...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.04.032
更新日期：2009-07-15 00:00:00
abstract：UNLABELLED:The popular medicine Passiflora edulis has been used as a sedative, tranquilizer, against cutaneous inflammatory diseases and intermittent fever. Most of the pharmacological investigations of Passiflora edulis have been addressed to its Central Nervous System activities, such as anxiolytic, anticonvulsant an...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2006.07.031
更新日期：2007-01-19 00:00:00
abstract：:The study of local knowledge about natural resources is becoming increasingly important in defining strategies and actions for conservation of medicinal plants. This study therefore sought to collect information from local population concerning the use of Ajloun Heights region medicinal plants; identify the most impor...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2006.09.031
更新日期：2007-03-21 00:00:00
abstract：:Aqueous EtOH (80%) extracts of seven plants used by Rwandan traditional healers to treat infections, were screened for antibacterial, antifungal, and antiviral activities. Only two of the selected plants showed a true antiviral activity against herpes simplex virus type 1, while all of them exhibited virucidal propert...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(98)00154-8
更新日期：1999-04-01 00:00:00
abstract：:The effects of 50% ethanol extract of one formulated ayurvedic product, consisting of a mixture of medicinal plant species, was investigated on behavioral despair test (forced swimming test, FST), central dopaminergic and serotonergic activity in rats. The effects on the forced swimming test were assessed along with t...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(00)00232-4
更新日期：2000-10-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Spatholobi Caulis is a traditional blood-activating and stasis-dispelling herb medicine, which has been used to treat diseases related to blood stasis syndrome (BSS) by inhibiting platelet aggregation, stimulate hematopoiesis, etc. It has been demonstrated that pro-angiogenesis could impr...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2016.10.075
更新日期：2017-03-22 00:00:00
abstract：AIM OF THE STUDY:The majority of people living in Kourittenga Province, Burkina Faso, are highly dependent on medicinal plants for their daily health care. Knowledge on the use of medicinal plants by traditional healers is being seriously threatened, due to the fact that it is commonly transferred from one generation t...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.10.010
更新日期：2011-01-27 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Argyreia speciosa (L.f), Sweet (Family Convolvulaceae) is used traditionally in Indian System of Medicine as aphrodisiac, rejuvenating agent, intellect promoting agent, brain tonic and in the therapy of hepatomegaly, diabetes and chronic ulcer. AIM OF THE STUDY:To study the gastroprotect...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2011.05.028
更新日期：2011-09-01 00:00:00
abstract：:Jigrine a polypharmaceutical herbal hepatoprotective formulation containing aqueous extracts of 14 medicinal plants is used in Indian system of medicine (Unani). Jigrine was evaluated for its hepatoprotective activity against galactosamine induced hepatopathy in rats. Galactosamine induced hepatotoxicity resembles hum...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2004.12.016
更新日期：2005-03-21 00:00:00
abstract：:Clerodendron colebrookianum Walp (family, Verbenaceae) has been used as a home remedy by the Mizo people of north eastern (NE) region of India in their folklore medicine as a cardioprotective (mainly against high blood pressure) agent. The scientific basis for their use has yet to be established. Therefore, in this in...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2003.09.022
更新日期：2004-01-01 00:00:00
abstract：:The use of herbal medicine in Jordan is very common. In order to evaluate the knowledge and the attitudes of the herbalists and acquire the common and less common medicinal herbs sold by the Jordanian herbalists, more than 100 herbalists throughout the country were interviewed and data concerning herbs present in thei...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(00)00215-4
更新日期：2000-09-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Kratom (Mitragyna speciosa Korth.) from the Rubiaceae family is an indigenous tropical medicinal tree of Southeast Asia. Kratom leaves have been used for decades in Malaysia and Thailand in traditional context for its perceived vast medicinal value, and as a mild stimulant among manual la...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.12.017
更新日期：2018-03-25 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The rhizomes of Kaempferia parviflora Wall. ex Baker have been traditionally used in Thailand to treat abscesses, gout, and peptic ulcers. AIM:Previously, we reported that the chloroform fraction of a Kaempferia parviflora extract had an inhibitory effect on rat paw-edema. In the present...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2011.01.013
更新日期：2011-07-14 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Arctium lappa and Tussilago farfara (Asteraceae) are two plant species used traditionally as antitubercular remedies. The aim of this study was (i) to screen Arctium lappa and Tussilago farfara extracts for activity against Mycobacterium tuberculosis and (ii) to isolate and identify the c...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2014.06.034
更新日期：2014-08-08 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Lilhocarpus polystachys Rehd. (Sweet Tea, ST) is a folk herbal medicine that has been traditionally used as a natural remedy for hypertension in China, whose mechanism remains unveiled. Flavonoid fraction is considered as the major active components in ST. This study aimed to provide expe...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2012.06.016
更新日期：2012-09-28 00:00:00
abstract：:Tanzania is endowed with a rich natural resource. The biodiversity comprises over 10,000 plant species, a rich fauna and marine resources. The collection of biological resources is guided by a set of formalities, namely: (i) entry visas, (ii) research permits, (iii) designation of a relevant collaborating host institu...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/0378-8741(95)01365-2
更新日期：1996-04-01 00:00:00
abstract：:Curculigo orchioides Gaerten belongs to the family Amaryllidaceae. The rhizomes of the plants are used for the treatment of decline in strength, jaundice and asthma. Its methanolic extract has been shown to enhance phagocytic activity of macrophages. Present studies have led to the isolation of two phenolic glycosides...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(03)00160-0
更新日期：2003-12-01 00:00:00
