Abstract：
:Ruxiang (Gummi olibanum), the dried gum resin of Boswellia carterii (BC), has been used in traditional Chinese medicine to alleviate pain and inflammation for thousands of years. In this random, blinded study, the anti-arthritic effects of a BC extract were observed and compared to vehicle control in a Lewis rat adjuvant arthritis model (n=8/group). Arthritis was induced by injecting CFA subcutaneously into the base of the tail, and the extract was administered orally (i.g.) for 10 consecutive days beginning on day 16 after the injection. Arthritic scores, paw edema, and the local tissue pro-inflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) were assessed. Toxicity and adverse effects of the extract were evaluated. At 0.90 g/kg per day, BC significantly decreased arthritic scores between days 20 and 25 (p<0.05) and reduced paw edema on days 18, 20 and 22 compared to control (p<0.05). It also significantly suppressed local tissue TNF-alpha and IL-1beta (p<0.05). No major adverse effects were observed in animals during the repeated-dose treatment profile although mild fur discoloration was noted. The data show that BC extract has significant anti-arthritic and anti-inflammation effects and suggest that these effects may be mediated via the suppression of pro-inflammatory cytokines.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Fan AY,Lao L,Zhang RX,Zhou AN,Wang LB,Moudgil KD,Lee DY,Ma ZZ,Zhang WY,Berman BMdoi
10.1016/j.jep.2005.03.033keywords:
subject
Has Abstractpub_date
2005-10-03 00:00:00pages
104-9issue
1-3eissn
0378-8741issn
1872-7573pii
S0378-8741(05)00303-Xjournal_volume
101pub_type
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journal_title：Journal of ethnopharmacology
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