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Therapeutic effects and mechanisms of total flavonoids of Turpinia Arguta Seen on adjuvant arthritis in rats.

Abstract：

AIM:To investigate the therapeutic effects and mechanisms of total flavonoids of Turpinia Arguta Seen (TFS) on adjuvant arthritis in rats. METHODS:The model of adjuvant arthritis was induced by injection of Freund's Complete Adjuvant (FCA). Secondary paw swelling of AA rats was measured with volume meter and polyarthritis index were scored. The splenocyte proliferation, (interleukin-1) IL-1 and interleukin-2 (IL-2) production were assayed by cell proliferation assay. Prostaglandin E(2) (PGE(2)) production was determined by radioimmunoassay. RESULTS:TFS (80, 160, 320 mg/kg, i.g.) could significantly inhibit secondary inflammatory reaction (secondary swelling, multiple arthritis, pathologic change of ankle arthritis) in AA rats. The results in vivo showed that the low response of splenocytes to concanavalin A (Con A) and lipopolysaccharide (LPS) and the decreased IL-2 synthesis were restored in AA rats treated with TFS (160, 320 mg/kg, i.g.), while the elevated IL-1 and PGE(2) released from peritoneal macrophages (PMphi) were also reduced. CONCLUSION:TFS has significant therapeutic effect on AA rats, which might be relate to its immunoregulatory actions.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Zhang L,Li J,Yu SC,Jin Y,Lv XW,Zou YH,Li Y

doi

10.1016/j.jep.2007.11.027

subject

Has Abstract

pub_date

2008-02-28 00:00:00

pages

167-72

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(07)00607-1

journal_volume

116

pub_type

杂志文章

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