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Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:The root of Scutellaria baicalensis Georgi, also called Huangqin in China, is an herbal-based nutraceutical which is usually used in Chinese medicated diet (CMD). As an abundant ingredient in Huangqin, wogonoside is a flavonoid glycoside. The present work investigated the anti-inflammatory activities of wogonoside in lipopolysaccharides (LPS)-induced RAW264.7 cells. MATERIALS AND METHODS:RAW264.7 cells were used. The inhibition of wogonoside against nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in LPS-induced RAW264.7 cells were measured. Additionally, the effects of wogonoside on mRNA expression of inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX2), TNF-α and IL-6 were also investigated. RESULTS AND DISCUSSION:Wogonoside not only dose-dependently decreased the production of inflammatory mediators including NO and PGE2 but also inhibited the release of pro-inflammatory cytokines including TNF-α and IL-6 in LPS-induced RAW264.7 cells. Furthermore, wogonoside possessed significantly in vitro inhibitory effects on the gene expression of iNOS, COX2, TNF-α and IL-6. CONCLUSION:These results suggest that wogonoside may be used as a functional food component for prevention and treatment of inflammation.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Yang YZ,Tang YZ,Liu YH

doi

10.1016/j.jep.2013.04.025

subject

Has Abstract

pub_date

2013-06-21 00:00:00

pages

271-6

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(13)00278-X

journal_volume

148

pub_type

杂志文章

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