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Effects of Papaver rhoeas extract on the acquisition and expression of morphine-induced conditioned place preference in mice.

Abstract：

:In the present study, the effects of water-alcohol extract of Papaver rhoeas on the acquisition and expression of morphine-induced conditioned place preference (CPP) in mice were investigated. Subcutaneous (s.c.) administration of morphine (1, 10 and 20 mg/kg) produced place preference. On the other hand, intraperitoneal (i.p.) administration of the plant extract (25, 50 and 100 mg/kg) did not show any effect. Injection of extract (25, 50 and 100 mg/kg, i.p.) 30 min before the morphine administration decreased the acquisition of morphine CPP. Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test did not change the expression of morphine-induced CPP. It could be concluded that Papaver rhoeas reduced the acquisition but not the expression of morphine-induced conditioned place preference.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Sahraei H,Fatemi SM,Pashaei-Rad S,Faghih-Monzavi Z,Salimi SH,Kamalinegad M

doi

10.1016/j.jep.2005.08.022

keywords:

subject

Has Abstract

pub_date

2006-02-20 00:00:00

pages

420-4

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(05)00539-8

journal_volume

103

pub_type

杂志文章

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