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Anti-platelet effects of bioactive compounds isolated from the bark of Rhus verniciflua Stokes.

Abstract：

:It has previously been shown that EtOAc extracts of Rhus verniciflua Stokes (RVS) inhibit the platelet aggregation response. In this report, bioassay-guided fractionation using ADP-, arachidonic acid-, and collagen-induced human platelet aggregation by a whole blood aggregometer yielded the bioactive compounds isomaltol and pentagalloyl glucose from different highly effective fractions. In addition, column chromatography of fractions from RVS yielded another five compounds: butin, fisetin, sulfuretin, butein and 3,4',7,8-tetrahydroxyflavone. We investigated the effects of bioactive compounds from RVS fractions on several markers of platelet activation using receptor expression on platelet membranes, including glycoprotein IIb/IIIa (CD41), GPIIb/IIIa-like expression (PAC-1) and P-selectin (CD62), and intracelluar calcium mobilization responses by flow cytometry in healthy subjects. Dose-dependent inhibition of platelet aggregation and significantly decreased platelet activation were observed for the isomaltol- and pentagalloyl glucose-treated platelets, respectively. These results show that isomaltol and pentagalloyl glucose from the bark of Rhus verniciflua Stokes have potent anti-platelet activity and emphasize the need to further examine the mechanism of these active compounds for platelet modulation.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Jeon WK,Lee JH,Kim HK,Lee AY,Lee SO,Kim YS,Ryu SY,Kim SY,Lee YJ,Ko BS

doi

10.1016/j.jep.2005.12.015

keywords:

subject

Has Abstract

pub_date

2006-06-15 00:00:00

pages

62-9

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(05)00834-2

journal_volume

106

pub_type

杂志文章

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