The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice.

Abstract:

:This study investigates anticonvulsant effects of an essential oil of the fruits of Pimpinella anisum (Umbelliferae), a folkloric remedy in the Iranian traditional medicine, against seizures induced by pentylenetetrazole (PTZ) or maximal electroshock (MES) in male mice. The essential oil suppressed tonic convulsions induced by PTZ or MES. It also elevated the threshold of PTZ-induced clonic convulsions in mice. The essential oil produced motor impairment. However, this effect was not observed at the doses and time courses needed for anticonvulsant activity.

journal_name

J Ethnopharmacol

authors

Pourgholami MH,Majzoob S,Javadi M,Kamalinejad M,Fanaee GH,Sayyah M

doi

10.1016/s0378-8741(98)00161-5

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

211-5

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(98)00161-5

journal_volume

66

pub_type

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