Abstract：
:Amphipterygium adstringens (Schltdl.) Standl. (Anacardiaceae) is widely used in traditional Mexican medicine for the treatment of gastritis and ulcers. In this work, we studied the anti-Helicobacter pylori activity of its bark, this Gram-negative bacterium is considered the major etiological agent of chronic active gastritis and peptic ulcer disease, and it is linked to gastric carcinoma. From a bio-guided assay of the fractions obtained form a continuous Soxhlet extraction of the bark, we identified that petroleum ether fraction had significant antimicrobial activity against Helicobacter pylori. From this fraction, we isolated an anacardic acids mixture and three known triterpenes: masticadienonic acid; 3alpha-hydroxymasticadienonic acid; 3-epi-oleanolic; as well as the sterol beta-sitosterol. Only the anacardic acids mixture exhibits a potent dose-dependent antibacterial activity (MIC=10 microg/ml in broth cultures). It is enriched in saturated alkyl phenolic acids (C15:0, C16:0, C17:0 C19:0) which represents a novel source of these compounds with potent anti-Helicobacter pylori activity. The promising use of anacardic acids and Amphipterygium adstringens bark in the development of an integral treatment of Helicobacter pylori diseases is discussed.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Castillo-Juárez I,Rivero-Cruz F,Celis H,Romero Idoi
10.1016/j.jep.2007.07.022subject
Has Abstractpub_date
2007-10-08 00:00:00pages
72-7issue
1eissn
0378-8741issn
1872-7573pii
S0378-8741(07)00365-0journal_volume
114pub_type
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The research into bioactive natural products originating from medicinal plants, fungi and other organisms has a long history, accumulating abundant and diverse publications. However no quantitative literature analysis has been conducted so far. AIM OF THE STUDY:Here we analyze the biblio...
journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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