The effects of sulfur fumigation processing on Panacis Quinquefolii Radix in chemical profile, immunoregulation and liver and kidney injury.

Abstract:

ETHNOPHARMACOLOGICAL RELEVANCE:The influence of sulfur fumigation processing on chemical profile, pharmacological activity and safety of Chinese herbs has attracted great attention. Panacis Quinquefolii Radix (PQR) was more widely used as edible and medicinal than Ginseng because of its tonifying effect and characteristic of not getting inflamed. The disadvantage of sulfur fumigated (SF) Ginseng has been reported, but the systematic study of SF-PQR is deficient and urgently needed. AIM OF THE STUDY:To systematically describe the influence of sulfur fumigation on chemical profile, characteristic products, immunoregulation and liver and kidney injury of PQR. MATERIALS AND METHODS:ICP-MS and HPLC-DAD were used to detect 11 inorganic elements and 3 ginsenosides, respectively. Principal component analysis (PCA) was used to distinguish SF-PQR from non-sulfur fumigated (NSF)-PQR by combining the content changes of inorganic elements and ginsenosides. UPLC/Orbitrap-MS was applied to screen the characteristic products (m/z) after sulfur fumigation. For the effectiveness and safety, male KM mice were used to compare the immunomodulatory effects of NSF-PQR or SF-PQR under both healty and cyclophosphamide induced immunosuppressive conditions by net growth rate of body weight, thymus and spleen indices, serum IL-6, SOD, BUN, AST levels, and HE staining of liver and kidney. RESULTS:Sulfur fumigation processing significantly reduced the contents of ginsenosides Rb1, Re and Rg1 with the elevation of inorganic elements in 20 batches PQR. Based on the scatter distribution of PCA, SF-PQR and NSF-PQR can be distinguished. According to the Rt, Precursor ion (m/z) and Product ion (m/z) produced by UPLC/Orbit trap-MS, R1-SO3 (m/z, 1059.53), Re-SO3 (m/z, 1025.55), Rg1-SO3 (m/z, 878.47), Ro-SO3 (m/z, 1035.32), Rb1-SO3 (m/z, 1179.58), and Rk3-SO3 (m/z, 745.40) could be confirmed as important markers for identifying SF-PQR. The effect of SF-PQR on reversing immunosuppression induced by cyclophosphamide was significantly reduced (P < 0.05) evidenced by the inhibition of net growth rate of body weight, immune organ index, IL-6 level and SOD activity. For healthy mice, SF-PQR not only failed to maintain the normal indexes, but also reduced the indexes to lower levels. After 2 weeks of continuous gastric administration, the abnormal liver and kidney functions in healthy mice were damaged and manifested by the increasing of BUN and AST levels, which was consistent with hepatic lesion area and renal tubular injury observed by HE staining. CONCLUSION:Sulfur fumigation processing not only reduced the immunomodulatory effect of PQR, but also brought the hidden danger in liver and kidney injury. The sulfonated products provided in this paper can be applied for the identification of SF-PQR accurately.

journal_name

J Ethnopharmacol

authors

Jiang J,Xiao S,Yan S,Zhang J,Xu X

doi

10.1016/j.jep.2019.112377

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

112377

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(19)32839-9

journal_volume

249

pub_type

杂志文章
  • Antimicrobial activity of certain Indian medicinal plants used in folkloric medicine.

    abstract::Fifty medicinal plants belonging to 26 families were studied for their antimicrobial activity. Among 50 plants tested, 72% showed antimicrobial activity. About 22 plant extracts from 15 families exhibited activity against both Gram-positive and Gram-negative bacteria. Fourteen plants belonging to 11 families did not s...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(00)00345-7

    authors: Srinivasan D,Nathan S,Suresh T,Lakshmana Perumalsamy P

    更新日期:2001-03-03 00:00:00

  • Biological and chemical study of paico (Chenopodium chilense, Chenopodiaceae).

    abstract::The methanolic extract of the aerial portion of Chenopodium chilense Schrad., used in Chilean traditional medicine as a remedy for stomach-ache, has been found to exert the major spasmolytic activity in acetylcholine contracted rat ileum. This extract, with a complex flavonoid patterns on thin layer chromatography (TL...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(97)00049-4

    authors: García R,Lemus I,Rivera P,Erazo S

    更新日期:1997-07-01 00:00:00

  • The composition and vascular/antioxidant properties of Taraxacum officinale flower water syrup in a normal-fat diet using an obese rat model.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Taraxacum officinale (L.), commonly called dandelion has been used for centuries as a natural medicine to treat inflammatory diseases including some metabolic alterations associated with obesity. AIM OF THE STUDY:Based on animal experiments this study aims to explore the potential mechan...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.113393

    authors: Majewski M,Lis B,Juśkiewicz J,Ognik K,Jedrejek D,Stochmal A,Olas B

    更新日期:2021-01-30 00:00:00

  • Antinociceptive and hypnotic properties of Celastrus orbiculatus.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Celastrus orbiculatus, a woody vine of the Celastraceae family, has been widely used as a traditional medicine for the treatment of many diseases, including rheumatoid arthritis and odontalgia. In this study, we assessed the sedative and antinociceptive activities of the methanolic extrac...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.07.052

    authors: Park HJ,Cha DS,Jeon H

    更新日期:2011-10-11 00:00:00

  • Ethnopharmacological evaluation of the informant consensus model on anti-tuberculosis claims among the Manus.

    abstract::Ethnobotanists often utilize predictive models to analyze the potential of indigenously used medicinal plants. The most common of these prognostic models is the informant consensus model. This study evaluates use of this model through the analytical ethnopharmacology of Manus Province, Papua New Guinea (PNG). The info...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2005.12.005

    authors: Case RJ,Franzblau SG,Wang Y,Cho SH,Soejarto DD,Pauli GF

    更新日期:2006-06-15 00:00:00

  • Korean red ginseng (Panax ginseng) inhibits obesity and improves lipid metabolism in high fat diet-fed castrated mice.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Korean red ginseng (Panax ginseng C.A. Meyer, Araliaceae) has been historically used as a traditional drug for the prevention and treatment of most ageing-related diseases, such as obesity, dyslipidemia, diabetes, and cardiovascular disease. Elderly men with testosterone deficiency are st...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2017.08.032

    authors: Shin SS,Yoon M

    更新日期:2018-01-10 00:00:00

  • Inhibition of lipopolysaccharide and interferon-gamma-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by Lithospermi radix in mouse peritoneal macrophages.

    abstract::Lithospermi radix (LR, root of Lithospermum erythrorhizon Siebold. et Zuccarinii) has been used to treat various conditions, such as septic shock, eczema and burns. In this study, the effect of LR on lipopolysaccharide (LPS) and recombinant interferon-gamma (rIFN-gamma)-induced production of nitric oxide (NO) and tumo...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2005.06.028

    authors: Chung HS,Kang M,Cho C,Park S,Kim H,Yoon YS,Kang J,Shin MK,Hong MC,Bae H

    更新日期:2005-12-01 00:00:00

  • Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:In Traditional Iranian Medicine (TIM), Melissa officinalis L. is commonly regarded as an effective therapy for heart palpitations. OBJECTIVE:Heart palpitation is a common complaint that is often benign and associated with a marked distress that makes the condition difficult to treat. Her...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jep.2015.02.007

    authors: Alijaniha F,Naseri M,Afsharypuor S,Fallahi F,Noorbala A,Mosaddegh M,Faghihzadeh S,Sadrai S

    更新日期:2015-04-22 00:00:00

  • Antinociceptive effect of the essential oil of Zingiber zerumbet in mice: possible mechanisms.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Zingiber zerumbet (L.) Smith, a wild edible ginger species or locally known as "lempoyang", commonly used in the Malays traditional medicine as an appetizer or to treat stomachache, toothache, muscle sprain and as a cure for swelling sores and cuts. AIM:The present study was conducted to...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.05.043

    authors: Khalid MH,Akhtar MN,Mohamad AS,Perimal EK,Akira A,Israf DA,Lajis N,Sulaiman MR

    更新日期:2011-09-01 00:00:00

  • Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Antimicrobial drug resistance is a growing threat to global public health. Historical records and herbal texts relating to traditional Celtic medicine indicate an extensive pharmacopeia of plants for treating infections likely caused by microbes. However, a major barrier for successful in...

    journal_title:Journal of ethnopharmacology

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.jep.2017.03.039

    authors: Wagner CS,De Gezelle J,Robertson M,Robertson K,Wilson M,Komarnytsky S

    更新日期:2017-05-05 00:00:00

  • In vitro evidence of phyto-synergy for plant part combinations of Croton gratissimus (Euphorbiaceae) used in African traditional healing.

    abstract:AIM OF THE STUDY:Despite the extensive traditional use of Croton gratissimus Burch. var. gratissimus for medicinal purposes, scientific studies validating the therapeutic properties of this indigenous plant are lacking. As the bark, roots and leaves of C. gratissimus are used separately as well as in combination, this ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2008.06.031

    authors: van Vuuren SF,Viljoen AM

    更新日期:2008-10-28 00:00:00

  • Screening of seven selected Rwandan medicinal plants for antimicrobial and antiviral activities.

    abstract::Aqueous EtOH (80%) extracts of seven plants used by Rwandan traditional healers to treat infections, were screened for antibacterial, antifungal, and antiviral activities. Only two of the selected plants showed a true antiviral activity against herpes simplex virus type 1, while all of them exhibited virucidal propert...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(98)00154-8

    authors: Sindambiwe JB,Calomme M,Cos P,Totté J,Pieters L,Vlietinck A,Vanden Berghe D

    更新日期:1999-04-01 00:00:00

  • The knowledge of medicinal plants in Africa today.

    abstract::The oral tradition for communication in Africa is stressed as well as the secrecy of the treatments with plants by traditional medicine-men. This makes it difficult to obtain more exact information on all the different aspects of traditional medicine. Nevertheless, some data have been collected in the Francophone coun...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(80)90022-7

    authors: Lantum DN

    更新日期:1980-03-01 00:00:00

  • Effect of Momordica charantia on key hepatic enzymes.

    abstract::The effect of Momordica charantia on certain key hepatic enzymes was investigated using male Sprague-Dawley rats as the animal model. Fruit juice and seed extract of Momordica charantia were administered orally at a daily dose of 1 ml/100 g body weight for 30 days under light ether anaesthesia while the control group ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(94)90074-4

    authors: Tennekoon KH,Jeevathayaparan S,Angunawala P,Karunanayake EH,Jayasinghe KS

    更新日期:1994-10-01 00:00:00

  • A lipid-soluble extract of Pinellia pedatisecta Schott enhances antitumor T cell responses by restoring tumor-associated dendritic cell activation and maturation.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Pinellia pedatisecta Schott (PPS)is a traditional Chinese medicine functioning as reducing swelling and drying dampness. Pinellia pedatisecta Schott extract (PE) has been confirmed to suppress cervical tumor growth and modulate the antitumor CD4+T helper immunity towards Th1. AIMS:To exp...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.111980

    authors: Wang Y,Huang H,Yao S,Li G,Xu C,Ye Y,Gui S

    更新日期:2019-09-15 00:00:00

  • IL-17A inhibitions of indole alkaloids from traditional Chinese medicine Qing Dai.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Qing Dai, a famous traditional Chinese medicine (TCM), is prepared by a traditional fermentation process with the aerial part of Strobilanthes cusia. Currently, this TCM could treat various clinical inflammatory diseases, such as ulcerative colitis and psoriasis, however, the bioactive co...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.112772

    authors: Lee CL,Wang CM,Kuo YH,Yen HR,Song YC,Chou YL,Chen CJ

    更新日期:2020-06-12 00:00:00

  • Can the aggregation be a new approach for understanding the mechanism of Traditional Chinese Medicine?

    abstract::"Frequent hitter" phenomenon emerged in the high-throughput screening; one of the most common mechanisms behind artifactual inhibition is that some organic molecules formed large colloid-like aggregates which are able to sequester and thereby inhibit enzymes. To investigate the situation in Traditional Chinese Medicin...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2008.02.017

    authors: Zhuang Y,Yan J,Zhu W,Chen L,Liang D,Xu X

    更新日期:2008-05-08 00:00:00

  • Qingxue jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-κB signaling pathways.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Qingxue jiedu Formulation (QF) is composed of two classic prescriptions which have been clinically used for more than 5 centuries and appropriately modified through basic theory of traditional Chinese medicine for treating various skin inflammation such as atopic dermatitis (AD), acute de...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.113773

    authors: Xiong X,Huang C,Wang F,Dong J,Zhang D,Jiang J,Feng Y,Wu B,Xie T,Cheng L

    更新日期:2020-12-31 00:00:00

  • Hypolipidemic effect of different extracts of Clerodendron colebrookianum Walp in normal and high-fat diet fed rats.

    abstract::Clerodendron colebrookianum Walp (family, Verbenaceae) has been used as a home remedy by the Mizo people of north eastern (NE) region of India in their folklore medicine as a cardioprotective (mainly against high blood pressure) agent. The scientific basis for their use has yet to be established. Therefore, in this in...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2003.09.022

    authors: Devi R,Sharma DK

    更新日期:2004-01-01 00:00:00

  • Anti-osteoporosis activity of Cibotium barometz extract on ovariectomy-induced bone loss in rats.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Recent research has confirmed that Cibotium barometz could inhibits osteoclast formation with no affect on BMM cell viability. However, the influence of Cibotium barometz on osteoporosis in animals is relatively unknown. The purpose of this study is to systemically investigate the effects...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.07.017

    authors: Zhao X,Wu ZX,Zhang Y,Yan YB,He Q,Cao PC,Lei W

    更新日期:2011-10-11 00:00:00

  • Ginkgo biloba extracts for tinnitus: More hype than hope?

    abstract::The investigation into the effects of Ginkgo biloba extracts on tinnitus has suffered from a dearth of effective animal models as well as systematic clinical trials employing double-blind and placebo-controlled designs. Some clinical trials have yielded positive results, however, these studies are few and have been li...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jep.2005.05.032

    authors: Smith PF,Zheng Y,Darlington CL

    更新日期:2005-08-22 00:00:00

  • Preclinical safety evaluation of the aqueous extract from Mangifera indica Linn. (Anacardiaceae): genotoxic, clastogenic and cytotoxic assessment in experimental models of genotoxicity in rats to predict potential human risks.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants widely used by the population contain significant concentrations of biologically active compounds and, although they have proven pharmacological properties, can cause DNA damage and develop fatal diseases. AIM OF THE STUDY:The present study aimed to evaluate the genotoxi...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.112086

    authors: Villas Boas GR,Rodrigues Lemos JM,de Oliveira MW,Dos Santos RC,Stefanello da Silveira AP,Bacha FB,Aguero Ito CN,Cornelius EB,Lima FB,Sachilarid Rodrigues AM,Costa NB,Bittencourt FF,Freitas de Lima F,Paes MM,Gubert P,Oesterr

    更新日期:2019-10-28 00:00:00

  • Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:A medicinal herb Curcuma longa Linn has been used for treating various liver diseases caused by hepatitis B virus (HBV) in Asia. AIM OF THE STUDY:The study was performed in order to investigate the antiviral activity of Curcuma longa Linn against HBV replication in liver cells. MATERIAL...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2009.04.046

    authors: Kim HJ,Yoo HS,Kim JC,Park CS,Choi MS,Kim M,Choi H,Min JS,Kim YS,Yoon SW,Ahn JK

    更新日期:2009-07-15 00:00:00

  • Anti-inflammatory activity of Eupatorium perfoliatum L. extracts, eupafolin, and dimeric guaianolide via iNOS inhibitory activity and modulation of inflammation-related cytokines and chemokines.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Eupatorium perfoliatum L. has been used traditionally for the treatment of fever, malaria and inflammation-associated diseases. Nowadays it is mostly used as immune activating remedy. The following study was performed to evaluate extracts with different polarity and defined lead-compounds...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.05.040

    authors: Maas M,Deters AM,Hensel A

    更新日期:2011-09-01 00:00:00

  • Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Korean red ginseng (KRG) has been shown to possess various biological activities including anti-inflammatory properties. AIM OF THE STUDY:We aimed to investigate the effects and mechanism of KRG on the prevention of atopic dermatitis (AD) using a mouse model. MATERIALS AND METHODS:The e...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2012.11.006

    authors: Cho E,Cho SH

    更新日期:2013-01-09 00:00:00

  • Medicinal plants used for cardiovascular diseases in Navarra and their validation from official sources.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:This paper provides significant ethnopharmacological information on plants used to treat cardiovascular diseases in Navarra, Spain. MATERIAL AND METHODS:Information was collected using semi-structured ethnobotanical interviews with 667 informants (mean age 72; 55.47% women, 44.53% men) i...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2014.09.047

    authors: Calvo MI,Cavero RY

    更新日期:2014-11-18 00:00:00

  • Synergistic interaction between the Ligusticum chuanxiong constituent butylidenephthalide and the nitric oxide donor sodium nitroprusside in relaxing rat isolated aorta.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Ligusticum chuanxiong Hort. (Umbelliferae), a traditional Chinese medicinal herb, is often prescribed together with nitric oxide donors for treating coronary heart diseases such as angina in China; however, studies concerning their pharmacological interaction are scarce. AIM OF THE STUDY...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2009.01.002

    authors: Chan SS,Jones RL,Lin G

    更新日期:2009-03-18 00:00:00

  • A Review of the Phytochemical, Pharmacological, Pharmacokinetic, and Toxicological Evaluation of Quercus Infectoria Galls.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Quercus Infectoria galls (QIG) have a long history of use in traditional Chinese medicine and traditional Uyghur medicine for the treatment of diarrhea, hemorrhage, skin disease, and many other human ailments. Medicinal applications of QIG have become increasingly popular in Greece, Asia ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jep.2020.113592

    authors: Elham A,Arken M,Kalimanjan G,Arkin A,Iminjan M

    更新日期:2020-11-17 00:00:00

  • Huperzia saururus, activity on synaptic transmission in the hippocampus.

    abstract::Huperzia saururus (Lam.) Trevis. (Lycopodiaceae) known as cola de quirquincho is used in folk medicine to improve memory. The cholinergic neurons of the basal forebrain, including those in the medial septum, and in the vertical limbs of the diagonal band of Broca and the nucleus basalis of Meynert, provide a major sou...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2005.11.002

    authors: Ortega MG,Vallejo MG,Cabrera JL,Pérez MF,Almirón RS,Ramírez OA,Agnese AM

    更新日期:2006-04-06 00:00:00

  • Is there an industrial future for phytopharmaceutical drugs? An outline of UNIDO programmes in the sector.

    abstract::Although a substantial proportion of the health-care expenditure of developing countries is spent on the acquisition of drugs, this is only sufficient to serve about a quarter of their population. Therefore it is inconceivable that WHO's goal of HEALTH FOR ALL by the year 2000 could even be approached without consider...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(91)90121-s

    authors: Wijesekera RO

    更新日期:1991-04-01 00:00:00