Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE:Cedrus atlantica essential oil (CaEO) presents analgesic and anti-inflammatory sedative properties. However, it remains unknown whether CaEO alleviates acute postoperative pain. MATERIALS AND METHODS:Here, we investigated the effect of CaEO on postoperative pain and its mechanisms related to the descending pain control in Swiss males mice induced by a plantar incision surgery (PIS) in the hindpaw. RESULTS:Inhalation of CaEO (5', 30' or 60') markedly reduced mechanical hypersensitivity. This effect was prevented by pre-treatment with naloxone or p-chlorophenylalanine methyl ester (PCPA, 100mg/kg, i.p.)-induced depletion of serotonin. In addition, p-alpha-methyl-para-tyrosin (AMPT, 100mg/kg, i.p.)-induced depletion of norepinephrine, intraperitoneal injection of the α2-adrenergic receptor antagonist yohimbine (0.15 mg/kg, i.p.) or haloperidol (1mg/kg, i.p.) an antagonist of dopaminergic (D1 and D2) receptors prevented the effect of CaEO on hypersensitivity. CONCLUSIONS:These findings suggest that CaEO alleviates postoperative pain by activating the descending pain modulation pathways on the opioidergic, serotonergic, noradrenergic (α2-adrenergic) and dopaminergic (dopamine D1 and D2 receptors) systems.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Martins DF,Emer AA,Batisti AP,Donatello N,Carlesso MG,Mazzardo-Martins L,Venzke D,Micke GA,Pizzolatti MG,Piovezan AP,dos Santos ARdoi
10.1016/j.jep.2015.08.048subject
Has Abstractpub_date
2015-12-04 00:00:00pages
30-8eissn
0378-8741issn
1872-7573pii
S0378-8741(15)30116-1journal_volume
175pub_type
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