当前位置： SCI文献检索 > MOLECULAR IMAGING AND BIOLOGY期刊下所有文献 > MicroCT liver contrast agent enhancement over time, dose, and mouse strain.

MicroCT liver contrast agent enhancement over time, dose, and mouse strain.

Abstract：

PURPOSE:The aim of this study was to examine strain differences in the uptake of Fenestra liver contrast agent (LC) in Nude, C57, and severe-combined immunodeficient (SCID) mice. In addition, we aimed to determine optimum dosing and to determine if there are positron emission tomography (PET)-attenuation effects on 2-deoxy-2[F-18]fluoro-D-glucose (FDG) values due to Fenestra LC. PROCEDURES:Nude, C57, and SCID mice were injected via tail vein at 5.0, 7.5, 10.0, and 15.0 ml/kg with contrast agent and imaged using micro computed tomography (microCT) 2 h after uptake and then daily up to 7 days. Mice were imaged by microPET/CT with FDG, with or without contrast agent. RESULTS:Significant variations in contrast were observed between mouse strains. SCID mice had significantly more spleen uptake of contrast than the other strains, and C57 mice had significantly more liver uptake of contrast than other strains. Across all strains, the spleen showed significantly higher uptake and duration of contrast than liver. Only the heart showed a significant attenuation of FDG uptake following contrast administration. CONCLUSIONS:Strain-specific variations in Fenestra LC uptake and signal duration were observed. At 7.5 ml/kg, this contrast agent is effective for imaging for 1 day, whereas at 15 ml/kg, it can be used up to 1 week. Fenestra LC does not appear to attenuate FDG uptake at 15 ml/kg for most tissues; therefore, it can be used in conjunction with microPET imaging studies.

journal_name

Mol Imaging Biol

journal_title

Molecular imaging and biology

authors

Suckow CE,Stout DB

doi

10.1007/s11307-007-0128-x

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

114-20

issue

2

eissn

1536-1632

issn

1860-2002

journal_volume

10

pub_type

杂志文章

相关文献

MOLECULAR IMAGING AND BIOLOGY文献大全
  • Evaluation of arginine deiminase treatment in melanoma xenografts using (18)F-FLT PET.

    abstract：PURPOSE:This study aims to develop a molecular imaging strategy for response assessment of arginine deiminase (ADI) treatment in melanoma xenografts using 3'-[(18)F]fluoro-3'-deoxythymidine ([(18)F]-FLT) positron emission tomography (PET). PROCEDURES:F-FLT response to ADI therapy was studied in preclinical models of m...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-013-0655-6

    authors： Stelter L,Fuchs S,Jungbluth AA,Ritter G,Longo VA,Zanzonico P,Raschzok N,Sauer IM,Bomalaski JS,Larson SM

    更新日期：2013-12-01 00:00:00

  • Targeting gelatinases with a near-infrared fluorescent cyclic His-Try-Gly-Phe peptide.

    abstract：PURPOSE:The purpose of the study is to synthesize and characterize near-infrared (NIR) fluorescence imaging probes targeted to gelatinases. PROCEDURES:A phage display-selected cyclic peptide containing the His-Try-Gly-Phe (HWGF) motif was used as the lead compound. Structure-activity relationship analysis was used to ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-009-0219-y

    authors： Wang W,Shao R,Wu Q,Ke S,McMurray J,Lang FF Jr,Charnsangavej C,Gelovani JG,Li C

    更新日期：2009-11-01 00:00:00

  • Mapping pH at Cancer Cell Surfaces.

    abstract：PURPOSE:To develop a tool to measure the pH at the surfaces of individual cells. PROCEDURES:The SNARF pH-sensitive dye was conjugated to a pHLIP® peptide (pH-Low Insertion Peptide) that binds cellular membranes in tumor spheroids. A beam splitter allows simultaneous recording of two images (580 and 640 nm) by a CCD ca...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-019-01335-4

    authors： Wei D,Engelman DM,Reshetnyak YK,Andreev OA

    更新日期：2019-12-01 00:00:00

  • A Novel Modality for Functional Imaging in Acute Intervertebral Disk Herniation via Tracking Leukocyte Infiltration.

    abstract：PURPOSE:Inflammation plays a key role in the progression of intervertebral disk (IVD) herniation and associated low back pain. However, real-time spatial diagnosis of inflammation associated with acute disk herniation has not been investigated. We sought to detect local neutrophil and macrophage infiltration near disk ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-016-1038-6

    authors： Xiao L,Ding M,Zhang Y,Chordia M,Pan D,Shimer A,Shen F,Glover D,Jin L,Li X

    更新日期：2017-10-01 00:00:00

  • Site-Specific Fluorescent Labeling of Antibodies and Diabodies Using SpyTag/SpyCatcher System for In Vivo Optical Imaging.

    abstract：PURPOSE:Construction of antibody-based, molecular-targeted optical imaging probes requires the labeling of an antibody with a fluorophore. The most common method for doing this involves non-specifically conjugating a fluorophore to an antibody, resulting in poorly defined, heterogeneous imaging probes that often have s...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-018-1222-y

    authors： Alam MK,El-Sayed A,Barreto K,Bernhard W,Fonge H,Geyer CR

    更新日期：2019-02-01 00:00:00

  • Evaluation of [99mTc]Radiolabeled Macrophage Mannose Receptor-Specific Nanobodies for Targeting of Atherosclerotic Lesions in Mice.

    abstract：PURPOSE:Macrophage accumulation characterizes the development of atherosclerotic plaques, and the presence of certain macrophage subsets might be an indicator of plaque phenotype and (in)stability. The macrophage mannose receptor (MMR) is expressed on alternatively activated macrophages and found at sites of intraplaqu...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-017-1117-3

    authors： Bala G,Baudhuin H,Remory I,Gillis K,Debie P,Krasniqi A,Lahoutte T,Raes G,Devoogdt N,Cosyns B,Hernot S

    更新日期：2018-04-01 00:00:00

  • Conditional bicistronic Cre reporter line expressing both firefly luciferase and β-galactosidase.

    abstract：PURPOSE:The Cre-loxP system has become an important strategy for conditional gene deletion and conditional gene expression in genetically engineered mice. To evaluate Cre recombinase expression, we generated reporter mice that permit both noninvasive imaging in living animals and either ex vivo histochemical/immunohist...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-010-0333-x

    authors： Ishikawa TO,Herschman HR

    更新日期：2011-04-01 00:00:00

  • Synthesis and optimization of the labeling procedure of 99mTc-HYNIC-interleukin-2 for in vivo imaging of activated T lymphocytes.

    abstract：INTRODUCTION:We have previously described the labeling of interleukin-2 (IL2) with (123)I and (99m)Tc-N(3)S. Both radiopharmaceuticals were successfully applied in humans to image several inflammatory lesions and autoimmune diseases characterized by tissue infiltrating lymphocytes expressing the IL2 receptor (CD25). Ho...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-009-0285-1

    authors： D'Alessandria C,di Gialleonardo V,Chianelli M,Mather SJ,de Vries EF,Scopinaro F,Dierck RA,Signore A

    更新日期：2010-10-01 00:00:00

  • Positron emission tomography/computed tomography of a rare xanthogranulomatous process: Erdheim-Chester disease.

    abstract：:Erdheim-Chester disease (ECD) is a disseminated xanthogranulomatous infiltrative disease of unknown etiology due to infiltration of different organs and bones by foamy histiocytes. A 37-year-old male with cerebral and periorbital lesions was diagnosed with this rare disease and was evaluated with magnetic resonance im...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1016/j.mibio.2004.01.023

    authors： Pereira Neto CC,Roman C,Johnson M,Jagasia M,Martin WH,Delbeke D

    更新日期：2004-01-01 00:00:00

  • Imaging the bio-distribution of fluorescent probes using multispectral epi-illumination cryoslicing imaging.

    abstract：PURPOSE:The increasing availability of fluorescent probes for in vivo optical imaging enables the interrogation of complex biological processes in small animals serving as models for human-like tissue function and disease. However, the validation of probe bio-distribution during their development or the study of differ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-010-0416-8

    authors： Sarantopoulos A,Themelis G,Ntziachristos V

    更新日期：2011-10-01 00:00:00

  • Molecular Imaging of PDE10A Knockout Mice with a Novel PET Radiotracer: [(11)C]T-773.

    abstract：PURPOSE:[(11)C]T-773 is a new radioligand for positron emission tomography (PET) targeting the phosphodiesterase 10A enzyme (PDE10A). PDE10A is highly expressed in the striatum by medium spiny neurons, and it has been demonstrated to be involved in the regulation of striatal signaling through the reduction of medium sp...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-015-0822-z

    authors： Tóth M,Häggkvist J,Stepanov V,Takano A,Nakao R,Amini N,Miura S,Kimura H,Taniguchi T,Gulyás B,Halldin C

    更新日期：2015-08-01 00:00:00

  • Exploring with [18F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy.

    abstract：PURPOSE:The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. PROCEDURES:Twenty Sprague Dawley male rats were administered with mul...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-020-01488-7

    authors： Serrano ME,Bahri MA,Becker G,Seret A,Germonpré C,Lemaire C,Giacomelli F,Mievis F,Luxen A,Salmon E,Rogister B,Raedt R,Plenevaux A

    更新日期：2020-10-01 00:00:00

  • Global cerebral blood flow in relation to cognitive performance and reserve in subjects with mild memory deficits.

    abstract：PURPOSE:This study was undertaken to explore the mechanisms underlying cognitive reserve in subjects with mild memory deficits by using positron emission tomography (PET). METHODS:Global cerebral blood flow (gCBF) and cerebrovascular reserve (CVR) measurements were performed in 15 elders (5 men, 10 women, 62-84, 71.8 ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-006-0066-z

    authors： Boles Ponto LL,Magnotta VA,Moser DJ,Duff KM,Schultz SK

    更新日期：2006-11-01 00:00:00

  • Bone metabolism after total hip revision surgery with impacted grafting: evaluation using H2 15O and [18F]fluoride PET; a pilot study.

    abstract：PURPOSE:To evaluate bone blood flow and bone formation in patients after total hip revision surgery with impacted bone grafting using H2 15O and [18F]fluoride positron emission tomography (PET). PROCEDURES:To asses bone blood flow and bone metabolism in bone allograft after impaction grafting, four patients treated wi...

    journal_title：Molecular imaging and biology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11307-008-0153-4

    authors： Temmerman OP,Raijmakers PG,Heyligers IC,Comans EF,Lubberink M,Teule GJ,Lammertsma AA

    更新日期：2008-09-01 00:00:00

  • Noninvasive reporter gene imaging of human Oct4 (pluripotency) dynamics during the differentiation of embryonic stem cells in living subjects.

    abstract：PURPOSE:Human pluripotency gene networks (PGNs), controlled in part by Oct4, are central to understanding pluripotent stem cells, but current fluorescent reporter genes (RGs) preclude noninvasive assessment of Oct4 dynamics in living subjects. PROCEDURES:To assess Oc4 activity noninvasively, we engineered a mouse embr...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-014-0744-1

    authors： Ahn BC,Parashurama N,Patel M,Ziv K,Bhaumik S,Yaghoubi SS,Paulmurugan R,Gambhir SS

    更新日期：2014-12-01 00:00:00

  • ImmunoPET Imaging of αvβ6 Expression Using an Engineered Anti-αvβ6 Cys-diabody Site-Specifically Radiolabeled with Cu-64: Considerations for Optimal Imaging with Antibody Fragments.

    abstract：PURPOSE:Increased expression of the αvβ6 integrin correlates with advanced tumor grade and poor clinical outcome, identifying αvβ6 as a prognostic indicator and an attractive target for molecular imaging. This work investigated the ability of a disulfide-stabilized [64Cu]NOTA-αvβ6 cys-diabody to image αvβ6 expression i...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-017-1097-3

    authors： White JB,Hu LY,Boucher DL,Sutcliffe JL

    更新日期：2018-02-01 00:00:00

  • Radiofluorination of PSMA-HBED via Al(18)F(2+) Chelation and Biological Evaluations In Vitro.

    abstract：PURPOSE:Ga-68-labeled prostate-specific membrane antigen (PSMA) ligands have been used clinically for positron emission tomography (PET) imaging of prostate cancer. However, F-18-labeled compounds offer several advantages, including the potential for delayed imaging, high starting activities enabling multidose preparat...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-015-0844-6

    authors： Malik N,Baur B,Winter G,Reske SN,Beer AJ,Solbach C

    更新日期：2015-12-01 00:00:00

  • 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography/computed tomography imaging evaluation of esophageal cancer.

    abstract：:We evaluated the clinical utility of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) on the precise localization of pathologic foci and exclusion of normal variants in the imaging evaluation of patients with esophageal carcinoma. Combined PET/CT scans were performed i...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-006-0036-5

    authors： Jadvar H,Henderson RW,Conti PS

    更新日期：2006-05-01 00:00:00

  • Validation of fluorescence molecular tomography/micro-CT multimodal imaging in vivo in rats.

    abstract：PURPOSE:Rats are important preclinical models for studying breast cancer metastasis and bone pathologies. In these research areas, fluorescence molecular tomography (FMT) is commonly applied for quantitative three-dimensional (3D) imaging in mice. However, uncertainties due to strong depth dependency of FMT signal and ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-013-0698-8

    authors： Vonwil D,Christensen J,Fischer S,Ronneberger O,Shastri VP

    更新日期：2014-06-01 00:00:00

  • MRI of ICAM-1 upregulation after stroke: the importance of choosing the appropriate target-specific particulate contrast agent.

    abstract：PURPOSE:Magnetic resonance imaging (MRI) with targeted contrast agents provides a promising means for diagnosis and treatment monitoring after cerebrovascular injury. Our goal was to demonstrate the feasibility of this approach to detect the neuroinflammatory biomarker intercellular adhesion molecule-1 (ICAM-1) after s...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-013-0617-z

    authors： Deddens LH,van Tilborg GA,van der Toorn A,van der Marel K,Paulis LE,van Bloois L,Storm G,Strijkers GJ,Mulder WJ,de Vries HE,Dijkhuizen RM

    更新日期：2013-08-01 00:00:00

  • Deep brain stimulation of the prelimbic medial prefrontal cortex: quantification of the effect on glucose metabolism in the rat brain using [(18) F]FDG microPET.

    abstract：PURPOSE:Prefrontal cortex (PFC) deep brain stimulation (DBS) has been proposed as a therapy for addiction and depression. This study investigates changes in rat cerebral glucose metabolism induced by different DBS frequencies using μPET. PROCEDURES:One hour DBS of the prelimbic area (PL) of the medial PFC (mPFC) (60 H...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-014-0757-9

    authors： Parthoens J,Verhaeghe J,Stroobants S,Staelens S

    更新日期：2014-12-01 00:00:00

  • In Vivo Evaluation of Magnetic Targeting in Mice Colon Tumors with Ultra-Magnetic Liposomes Monitored by MRI.

    abstract：PURPOSE:The development of theranostic nanocarriers as an innovative therapy against cancer has been improved by targeting properties in order to optimize the drug delivery to safely achieve its desired therapeutic effect. The aim of this paper is to evaluate the magnetic targeting (MT) efficiency of ultra-magnetic lip...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-018-1238-3

    authors： Thébault CJ,Ramniceanu G,Michel A,Beauvineau C,Girard C,Seguin J,Mignet N,Ménager C,Doan BT

    更新日期：2019-04-01 00:00:00

  • Comparison of (18)F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression.

    abstract：PURPOSE:CXCR4 is overexpressed on tumor cells from many types of human cancers. A high level of CXCR4 expression often correlates with poor prognosis, chemotherapy resistance, and metastasis. The development of CXCR4-specific radiotracers for positron emission tomography (PET) imaging will allow in vivo evaluation of r...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-013-0640-0

    authors： Zhang XX,Sun Z,Guo J,Wang Z,Wu C,Niu G,Ma Y,Kiesewetter DO,Chen X

    更新日期：2013-12-01 00:00:00

  • Quantitative measurement of regional blood flow in hepatic focal nodular hyperplasia. Findings on positron emission tomography.

    abstract：:The blood flow through normal liver parenchyma and a pathologically proven hepatic region of focal nodular hyperplasia (FNH) of the lateral lobe, was measured in a single patient in a quantitative manner using regional dynamic positron emission tomography (PET) imaging with O-15 carbon dioxide (steady state) and O-15 ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1016/s1536-1632(01)00002-6

    authors： Kunishima S,Koh T,Fukuda K,Taniguchi H

    更新日期：2002-05-01 00:00:00

  • Non-invasive Standardised Uptake Value for Verification of the Use of Previously Validated Reference Region for [18F]Flortaucipir and [18F]Florbetapir Brain PET Studies.

    abstract：PURPOSE:The simplified reference tissue model (SRTM) is commonly applied for the quantification of brain positron emission tomography (PET) studies, particularly because it avoids arterial cannulation. SRTM requires a validated reference region which is obtained by baseline-blocking or displacement studies. Once a refe...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-020-01572-y

    authors： de Vries BM,Timmers T,Wolters EE,Ossenkoppele R,Verfaillie SCJ,Schuit RC,Scheltens P,van der Flier WM,Windhorst AD,van Berckel BNM,Boellaard R,Golla SSV

    更新日期：2021-01-14 00:00:00

  • Correction to: Differentiation of Malignant and Benign Head and Neck Tumors with Amide Proton Transfer-Weighted MR Imaging.

    abstract：:This article is about head and neck tumor MR imaging and is not within the scope of two National Institutes of Health grants (R0ICA166171, ROICA228188) erroneously listed. Thus, the authors would like to remove the reference to the NIH grants R01CA166171 and R01CA228188 in this article. ...

    journal_title：Molecular imaging and biology

    pub_type： 已发布勘误

    doi：10.1007/s11307-019-01459-7

    authors： Yu L,Li C,Luo X,Zhou J,Zhang C,Zhang Y,Chen M

    更新日期：2020-02-01 00:00:00

  • In Vivo MR Imaging of Dual MRI Reporter Genes and Deltex-1 Gene-modified Human Mesenchymal Stem Cells in the Treatment of Closed Penile Fracture.

    abstract：PURPOSE:The purpose of this study was to investigate the feasibility of dual magnetic resonance imaging (MRI) reporter genes, including ferritin heavy subunit (Fth) and transferrin receptor (TfR), which provide sufficient MRI contrast for in vivo MRI tracking, and the Deltex-1 (DTX1) gene, which promotes human mesenchy...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-017-1128-0

    authors： Guo R,Li Q,Yang F,Hu X,Jiao J,Guo Y,Wang J,Zhang Y

    更新日期：2018-06-01 00:00:00

  • Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans.

    abstract：PURPOSE:[18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. PROCEDURES:Six healthy volunteers (three males and three females) were whole-body PET ...

    journal_title：Molecular imaging and biology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11307-016-0955-8

    authors： Choi JY,Lyoo CH,Kim JS,Kim KM,Lee M,Ryu YH

    更新日期：2016-12-01 00:00:00

  • Sigma-2 receptor as potential indicator of stem cell differentiation.

    abstract：PURPOSE:The sigma-2 (σ(2)) receptor is a potential biomarker of proliferative status of solid tumors. Specific synthetic probes using N-substituted-9-azabicyclo [3.3.1]nonan-3α-yl carbamate analogs have been designed and implemented for experimental cancer diagnosis and therapy. PROCEDURES:We employed the fluorescentl...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-011-0493-3

    authors： Haller JL,Panyutin I,Chaudhry A,Zeng C,Mach RH,Frank JA

    更新日期：2012-06-01 00:00:00

  • Imaging of gadolinium spatial distribution in tumor tissue by laser ablation inductively coupled plasma mass spectrometry.

    abstract：PURPOSE:Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was utilized in postmortem imaging of gadolinium (Gd) spatial distribution in a mouse tumor model postadministration of PEGylated Gd liposomal nanoparticles. PROCEDURES:PEGylated liposomal nanoparticles were formulated using a paramagnetic...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-009-0282-4

    authors： Kamaly N,Pugh JA,Kalber TL,Bunch J,Miller AD,McLeod CW,Bell JD

    更新日期：2010-08-01 00:00:00